Efficacy Study of Oral Collagen Peptide on Skin Condition Improvement

NCT06847035 | Completed

• 1 other identifier: YKEC-2024-001
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

To assess if oral intake of collagen peptide can improve skin conditions such as skin thickness, density and firmness.

Conditions

Skin Aging

Outcome Measures

Primary Outcomes (3)

• Skin firmness

  The changes of skin firmness parameter tested by Cutometer MPA580

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

• Skin thickness

  The changes of skin thickness （μm） tested by Ultrascan UC 22

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

• Skin density

  The changes of skin density tested by Ultrascan UC 22

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

Secondary Outcomes (3)

• Skin hydration

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

• Skin barrier

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

• Facial image

  before product treatment (T 0), after 8 weeks(T 1)and 12 weeks(T 2) of daily product intake, 4 weeks after the last intake(T 3, 4-week regression phase)

Study Arms (2)

Active Comparator

ACTIVE COMPARATOR

collagen peptide solid beverage

Dietary Supplement: Active Comparator

Placebo Comaprator

PLACEBO COMPARATOR

placebo solid beverage

Dietary Supplement: Placebo Comparator

Interventions

Active Comparator DIETARY_SUPPLEMENT

LISAVEI collagen peptide solid beverage ( contain 5 g collagen peptide)，once daily for 12 weeks

Active Comparator

Placebo Comparator DIETARY_SUPPLEMENT

placebo solid beverage (Maltodextrin with edible flavor)，once daily for 12 weeks

Also known as: placebo solid beverage

Placebo Comaprator

Eligibility Criteria

• Age: 35 Years - 55 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy female adults aged between 35-55 years old
• With fine wrinkles and skin laxity
• Personal informed consents to participate in the study
• Agree to keep their daily skincare routine unchanged for the duration of the study
• Maintain good sun protection habits
• \. Agree to refrain from wearing make-up on the face on the each study visit

You may not qualify if:

• Female who is pregnant or nursing or planning to become pregnant during the course of the study
• Individuals who are in the perimenopausal stage.
• BMI\<18.5 or BMI \>27.9
• Individuals suffering from chronic systemic diseases such as cardiovascular, cerebrovascular, liver, and kidney diseases.
• Individuals who have diabetes.
• Individuals suffering from skin conditions such as psoriasis, eczema, atopic dermatitis, and severe acne.
• Individuals with depression or sleep disorders, those who smoke, and those who abuse alcohol.
• Individuals who are using hormonal drugs, medications for obesity, absorption inhibitors, antidepressants, or appetite suppressants.
• Individuals who have used hormones or anti-inflammatory drugs on their face and upper arms within the past two months.
• Individuals who received facial laser therapy, chemical peeling or UV overexposure in the past 3 months
• Individuals who can not avoid prolonged exposure to sunlight.
• Individuals who are currently participating in other clinical studies or trials.

Sponsors & Collaborators

• Shanghai Meifute Biotechnology Co., Ltd: lead

Study Sites (1)

Shanghai Fumei Dermatology Clinic

Shanghai, Shanghai Municipality, 021, China

Location

Related Publications (1)

• Wang Y, Zhu W, Luo W, Ma Y, Zhou Y. The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study. J Cosmet Dermatol. 2025 Dec;24(12):e70565. doi: 10.1111/jocd.70565.

  PMID: 41311286 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: February 26, 2025
• Study Start: July 25, 2024
• Primary Completion: November 19, 2024
• Study Completion: November 19, 2024
• Last Updated: February 28, 2025

Record last verified: 2025-01

Locations

CN (1)