NCT07084701

Brief Summary

This Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults with Sleep deprivation: A Proof-of-Concept Study aims to investigate the effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on memory and cognitive function in adults experiencing sleep deprivation(SD). Given the known impact of SD on cognitive performance, this study seeks to explore whether NSCLD, as a non-invasive intervention, can mitigate the cognitive impairments associated with SD.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
7mo left

Started Sep 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress53%
Sep 2025Dec 2026

First Submitted

Initial submission to the registry

July 8, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

July 24, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

September 15, 2025

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2026

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

January 13, 2026

Status Verified

December 1, 2025

Enrollment Period

9 months

First QC Date

July 8, 2025

Last Update Submit

January 11, 2026

Conditions

Sleep Deprivation

Keywords

Sleep DeprivationNon-Invasive Superficial Craniocervical Lymphatic DrainageMemoryCognitive FunctionNSCLD

Outcome Measures

Primary Outcomes (2)

  • Digit Span Test

    Evaluate memory function. 1 point for each correct string of numbers. Total score: forward score + backward score. Higher scores mean a better outcome.

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • Montreal Cognitive Assessment (MoCA)

    The maximum score is 30 points. ≥26 points is normal. Higher scores mean a better outcome.

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

Secondary Outcomes (7)

  • Changes in anxiety, stress, irritability, etc. before and after instant massage

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • Brain metabolic markers and other metabolic indicators

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • EEG power in alpha, beta, delta and theta band

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • Heart rate variability (HRV)

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • modified TOEFL iBT

    Day 1 (Baseline) and Day 2, repeat after a 2-week washout period

  • +2 more secondary outcomes

Study Arms (2)

NSCLD group

EXPERIMENTAL

NSCLD for 30 minutes, repeated after a 10-minute interval

Device: Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD)

Control group

SHAM COMPARATOR
Device: sham-intervention treatment

Interventions

Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD)DEVICE

Participants will be randomly assigned to either an intervention group receiving NSCLD or a control group receiving a sham-intervention treatment. Cognitive function will be assessed using standardized tests before and after the intervention.

NSCLD group
sham-intervention treatmentDEVICE

Participants will be randomly assigned to either an intervention group receiving NSCLD or a control group receiving a sham-intervention treatment. Cognitive function will be assessed using standardized tests before and after the intervention.

Control group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • College student ≥18 years, all of whom have passed a standardized entrance examination;
  • No failed exams during the course of study;
  • Sleep deprivation;
  • In good health, with no mental or psychological disorders;
  • No recent use of medications that may affect memory and cognition;
  • Voluntary participation and able to undergo cognitive function and memory testing;
  • Informed consent provided

You may not qualify if:

  • Pregnant or breastfeeding women.
  • Presence of acute or chronic medical conditions (e.g., severe hypertension, diabetes, cardiovascular disease) that could confound the results.
  • History of craniocervical trauma or surgery.
  • Current use of sedative or anxiolytic medications that could influence sleep or cognitive function.
  • Participants who are unable to follow the procedures or complete the assessments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tianjin Medical University General Hospital

Tianjin, China

RECRUITING

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

DyssomniasSleep Wake DisordersNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMental Disorders

Central Study Contacts

Tao Liu, MD

CONTACT

86-18302204804TLiu1@georgeinstitute.org.au

Yuezheng Dou

CONTACT

douyz@tmu.edu.cn

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

July 8, 2025

First Posted

July 24, 2025

Study Start

September 15, 2025

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

January 13, 2026

Record last verified: 2025-12

Locations

CN(1)