Beyond Platelet Indices, WBC-to-MPV Ratio in Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) Correlate With Short-Term Rather Than In-Hospital Outcomes

NCT07076732 | Completed

• 1 other identifier: Soh-Med-25-1-1PD
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the role of platelet indices and the \[White blood cell (WBC) /mean platelet volume (MPV)\] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with non-obstructive coronary arteries (MINOCA) to assess their predictive value for short-term clinical outcomes.

Conditions

Obstructive Coronary Arteries; Platelet Indices; White Blood Cell; Mean Platelet Volume; Myocardial Infarction; Short-Term Outcomes

Outcome Measures

Primary Outcomes (1)

• White blood cell count to mean platelet volume ratio (WMR)

  White blood cell count to mean platelet volume ratio (WMR) will be recorded.

  Within 6 hours of symptom onset

Secondary Outcomes (1)

• Incidence of major adverse cardiovascular events

  1 month post-procedure

Study Arms (2)

Study group

Myocardial infarction with nonobstructive coronary arteries (MINOCA) patients

Other: Coronary Angiography; Other: SYNTAX Score

Control group

Healthy control individual.

Other: Coronary Angiography; Other: SYNTAX Score

Interventions

Coronary Angiography OTHER

Coronary angiograms will be acquired digitally for quantification.

Control group; Study group

SYNTAX Score OTHER

Upon retrieval of a version from http://www.syntaxscore.com, the anatomical SYNTAX score will be implemented to numerically evaluate the intricacy of coronary lesions.

Control group; Study group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This case-control study will be performed at Sohag University Hospitals after approval from the institutional ethical committee.

You may qualify if:

• Age ≥18 years old.
• Both sexes.
• Patients with acute myocardial infarction (AMI). Myocardial infarction with nonobstructive coronary arteries (MINOCA) is diagnosed if a patient fulfilled the AMI criteria in the absence of obstructive coronary arteries (type I: \<50% stenosis; or type II: no stenosis) as recommended by the recent American Heart Association statement that introduces an updated definition incorporating the 4th universal MI definition, which by agreement excludes Takotsubo syndrome and myocarditis from the eventual diagnosis of MINOCA.

You may not qualify if:

• Previous history of MI or coronary revascularization (PCI or bypass surgery) with acute/chronic infection.
• Autoimmune diseases.
• Systemic inflammatory disease.
• Patients on treatment therapy which critically affects inflammatory cell count.
• Patients with malignancy.
• Chronic kidney disease.
• Severe liver disease.
• Severe anemia.
• Fever (\>38°C).

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

Location

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.

Study Record Dates

• First Submitted: July 12, 2025
• First Posted: July 22, 2025
• Study Start: January 1, 2025
• Primary Completion: July 10, 2025
• Study Completion: July 10, 2025
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)