Predicting Myocardial Infarction After Abdominal Surgery: Clinical Scores & Biomarkers

NCT06767943 | Completed

• 1 other identifier: Rc 6-11-2024
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

All patients undergoing non-cardiac surgery who met the inclusion criteria underwent a preoperative evaluation using specific assessment tools. Following surgery, patients were closely monitored in the intermediate care unit for the first 24 hours for the development of acute myocardial infarction (AMI). AMI was diagnosed based on the presence of chest pain, elevated cardiac biomarkers, and specific electrocardiogram (ECG) and echocardiogram findings.

Conditions

Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• The proportion of patients reported having at least a 50% incidence of Myocardial Infarction (measured by the Relevant Changes in 12-Leads ECG) in correlation with blood biomarkers.

  The incidence of Myocardial infarction after major abdominal surgery detected by relevant changes in 12 leads ECG and in correlation to presence of blood biomarkers

  50 Days

Study Arms (1)

Myocardial Infarction After Non-Cardiac Surgery (MINS) Syndrome Group

Diagnostic Test: 12-lead electrocardiography

Interventions

12-lead electrocardiography DIAGNOSTIC_TEST

All patients were admitted to the intermediate care unit for the 1st 24-h PO for follow-up for the possibility of developing acute myocardial infarction (AMI), which was diagnosed according to the 2017 ESC Guidelines; by 12- lead electrocardiography

Myocardial Infarction After Non-Cardiac Surgery (MINS) Syndrome Group

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients assigned for non-cardiac surgeries who fulfilled the inclusion criteria underwent preoperative evaluation using the assessment tools. All patients were admitted to the intermediate care unit for the 1st 24-h PO for follow-up for the possibility of developing acute myocardial infarction (AMI), which was diagnosed according to the 2017 ESC Guidelines and was differentiated as STEMI and NSTEMI.

You may qualify if:

• Patients older than 45,
• Patients of ASA-PS grade II-IV,
• Patients who prepared for non-cardiac surgeries of SSS of II-IV,

You may not qualify if:

• Patients signed the written consent for the study precipitation.
• Patients of ASA-PS grade I or V,
• Patients younger than 60 years,
• Patients planned to undergo surgeries of SSS \>IV,
• Patients were severely frail with CFS\>6,
• Patients had abnormal preoperative electrocardiography (ECG),
• Patients had a history of previous major cardiac or cerebrovascular events,
• Patient had disturbed cognitive function, coagulopathy, severe anemia with hemoglobin concentration (HBC) \< 7 gm/dl.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Benha University

Banhā, El Qalyoubia, 13511, Egypt

Location

MeSH Terms

Conditions

Myocardial Infarction

Interventions

Electrocardiography

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Anesthesia, Pain & ICU

Study Record Dates

• First Submitted: January 6, 2025
• First Posted: January 10, 2025
• Study Start: November 15, 2024
• Primary Completion: January 1, 2025
• Study Completion: January 31, 2025
• Last Updated: April 1, 2025

Record last verified: 2025-03

Locations

EG (1)