Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow
1 other identifier
interventional
14
2 countries
2
Brief Summary
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2025
Shorter than P25 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 28, 2025
CompletedStudy Start
First participant enrolled
May 28, 2025
CompletedFirst Posted
Study publicly available on registry
July 14, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2025
CompletedJuly 14, 2025
July 1, 2025
3 months
May 28, 2025
July 2, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Cerebral Blood Velocity
Transcranial Doppler ultrasound will be used to measure blood velocity in the middle cerebral artery and posterior cerebral artery. Location of measurements will remain consistent within participants.
3 hours
Secondary Outcomes (8)
Cardiac Output
3 hours
Blood Pressure
3 hours
Ventilatory Threshold
3 hours
End-Tidal Gases
3 hours
Rate of Oxygen Consumption and Carbon Dioxide Production
3 hours
- +3 more secondary outcomes
Study Arms (2)
High Altitude (3800m; Barcroft Research Station)
EXPERIMENTALHigh altitude setting
Low Altitude (334m; University of Guelph)
EXPERIMENTALLow altitude setting
Interventions
0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Eligibility Criteria
You may qualify if:
- \- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California
You may not qualify if:
- BMI \> 30
- No prescribed medications (oral contraceptives excluded)
- History of smoking
- Currently following a ketogenic diet or consuming exogenous ketogenic supplements
- History of heart, lung, blood vessel, or kidney disease
- Currently pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Barcroft Research Station
Bishop, California, 93514, United States
University of Guelph
Guelph, Ontario, N1G 2W1, Canada
Related Publications (1)
Gaskill SE, Ruby BC, Walker AJ, Sanchez OA, Serfass RC, Leon AS. Validity and reliability of combining three methods to determine ventilatory threshold. Med Sci Sports Exerc. 2001 Nov;33(11):1841-8. doi: 10.1097/00005768-200111000-00007.
PMID: 11689733BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
May 28, 2025
First Posted
July 14, 2025
Study Start
May 28, 2025
Primary Completion
August 31, 2025
Study Completion
August 31, 2025
Last Updated
July 14, 2025
Record last verified: 2025-07