The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists

NCT05226962 | Completed

• 1 other identifier: 13837
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling time trial performance. Participants will perform two trials in a randomized order. Each trial will involve a 20-minute bout of cycling on a stationary ergometer. Participants will ingest either a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise responses.

Conditions

Exercise; Ketosis

Keywords

Performance

Outcome Measures

Primary Outcomes (1)

• Power output

  Mean power output produced while cycling

  20-minute measurement during exercise

Secondary Outcomes (4)

• Heart rate

  20-minute measurement during exercise

• Perceived exertion

  Single measurement immediately after exercise

• Blood ketone

  Single measurement immediately prior to exercise

• Blood glucose

  20-minute measurement during exercise

Study Arms (2)

Ketone

ACTIVE COMPARATOR

An acute bout of exercise performed after the ingestion of a commercial ketone monoester supplement.

Dietary Supplement: Ketone monoester

Control

PLACEBO COMPARATOR

An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement.

Other: Placebo

Interventions

Ketone monoester DIETARY_SUPPLEMENT

A commercial liquid supplement ingested in a dose intended to provide \~0.35 g of ketone monoester per kg body mass of the participant

Ketone

Placebo OTHER

A liquid placebo that is volume- and taste-matched to the ketone monoester supplement

Control

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Habitually ingesting \>50 g of dietary carbohydrate daily i.e. not following a ketogenic diet.
• Regularly performing cycling exercise at least 3 days per week and for a total of ≥5 hours per week.
• Having an estimated peak oxygen uptake of ≥55 ml/kg/min for males and ≥48 ml/kg/min for females based on the online fitness calculator available at: www.worldfitnesslevel.org.
• Having competitive cycling experience.

You may not qualify if:

• \- Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire.

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

McMaster University

Hamilton, Ontario, L8S4K1, Canada

Location

MeSH Terms

Conditions

Motor Activity; Ketosis

Condition Hierarchy (Ancestors)

Behavior; Acidosis; Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Martin Gibala, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 27, 2022
• First Posted: February 7, 2022
• Study Start: February 15, 2022
• Primary Completion: September 1, 2022
• Study Completion: October 1, 2022
• Last Updated: November 7, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)