Ketone Esters and Metabolism During Recovery from Endurance Exercise

NCT06846840 | Active Not Recruiting

• 1 other identifier: 5202-6834
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance. The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.

Conditions

Exercise; Metabolism

Outcome Measures

Primary Outcomes (1)

• Glucose concentrations

  Blood glucose concentrations during the recovery period (240 minutes)

  240 minutes

Secondary Outcomes (2)

• Non-oxidative fate of ingested sucrose

  240 minutes

• Exercise capacity

  240 minutes

Other Outcomes (6)

• Blood beta-hydroxybutyrate concentrations

  240 minutes

• Urinary urea

  240 minutes

• Blood lactate concentrations

  240 minutes

Study Arms (2)

PLACEBO

PLACEBO COMPARATOR

Energy matched placebo containing medium-chain triglycerides and bitter taste

Dietary Supplement: Placebo

KETONE

EXPERIMENTAL

Beta-hydroxybutyrate monoester

Dietary Supplement: Ketone ester

Interventions

Ketone ester DIETARY_SUPPLEMENT

0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl

KETONE

Placebo DIETARY_SUPPLEMENT

Medium chain triglycerides and bitter tastant (Bitrex)

PLACEBO

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• VO2max ≥ 45mL.kg-1.min-1
• Weekly aerobic training \> 3hours.
• years running experience.
• BMI \< 30kg/m2

You may not qualify if:

• \<18yrs or \>60yrs of age
• Habitual smoker within last 5 years.
• History of uncontrollable metabolic or respiratory disease.
• Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
• History of Irritable Bowel Syndrome

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

University of Bath

Bath, Bath, BA2 7AY, United Kingdom

Location

MeSH Terms

Conditions

Motor Activity

Interventions

formic acid 4-(3-oxobutyl)phenyl ester

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Nutrition and Metabolism

Study Record Dates

• First Submitted: February 20, 2025
• First Posted: February 26, 2025
• Study Start: November 1, 2024
• Primary Completion: February 17, 2025
• Study Completion: May 1, 2025
• Last Updated: February 26, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)