Brachial-radial Pressure Gradient Phenomenon in Critically Ill Patients Treated With Vasoactive Agents

NCT07061457 | Completed

• 1 other identifier: 118.0043.1.305.2024
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 3

Brief Summary

The goal of this observational study is to observe brachial-to-radial pressure gradient in critically-ill patients receiving vasoactive agents. The main questions it aims to answer are:

1. 1.What is the frequency of brachial-to-radial gradient in critically-ill patients receiving vasoactive agents?
2. 2.Is brachial-to-radial gradient greater in patients receiving high doses of vasoactive agents?
3. 3.Is brachial-to-radial gradient associated with worse peripheral perfusion?

Conditions

Circulatory Failure; Shock; Vasopressor Agents; Blood Pressure

Keywords

brachial-to-radial gradient; vasoactive agents; vasopressor; critically ill

Outcome Measures

Primary Outcomes (1)

• Frequency of significant brachial-to-radial gradient

  Frequency of significant brachial-to-radial gradient \> 11 mmHg MAP

  At baseline (after initial resuscitation). The gradient will be assessed only once, in a cross-sectional manner.

Secondary Outcomes (3)

• Determinants of the brachial-to-radial gradient

  At baseline (after initial resuscitation). The variables will be collected only once in a cross-sectional manner.

• Brachial-to-radial gradient and capillary refill time

  At baseline (after initial resuscitation). Variables will be collected only once in a cross-sectional manner.

• Brachial-to-radial gradient and lactates

  At baseline (after initial resuscitation). Variables will be collected only once in a cross-sectional manner.

Study Arms (1)

Adult critically-ill patients receiving vasoactive agents

Adult critically-ill patients receiving vasoactive agents and undergoing invasive blood pressure monitoring in the radial artery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients admitted to the intensive care unit, requiring invasive blood pressure monitoring, and undergoing vasoactive therapy.

You may qualify if:

• adult (\>18 years) patients admitted to the ICU
• must be after initial resuscitation
• invasive blood pressure monitoring in the radial artery
• need for vasoactive drug therapy

You may not qualify if:

• pregnancy
• pressure transduction across invasive blood pressure circuit deemed to be inadequate
• mechanical circulatory support
• inability to match non-invasive cuff size to the patient's arm
• need for any hemodynamic intervention during performing study's measurements
• patient's decline to have the measurements done

Sponsors & Collaborators

• Jagiellonian University: lead

Study Sites (3)

5 Szpital Wojskowy z Polikliniką w Krakowie

Krakow, Poland

Location

Uniwersytecki Szpital w Opolu

Opole, Poland

Location

Uniwersyteckie Centrum Kliniczne w Warszawie

Warsaw, Poland

Location

MeSH Terms

Conditions

Shock; Critical Illness

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Study Officials

• Zbigniew Putowski, MD PhD

  Center for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Cracow, Poland

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 18, 2025
• First Posted: July 11, 2025
• Study Start: April 14, 2025
• Primary Completion: July 31, 2025
• Study Completion: August 31, 2025
• Last Updated: November 20, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

PL (3)