Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients

NCT07242027 | Completed

• 1 other identifier: SUM-SKNIPG-LARCARPAR-ICU-2025
• Study Type: observational
• Target: 212
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to determine whether three blood test ratios - lactate-to-albumin, CRP-to-albumin, and procalcitonin-to-albumin - can predict in-hospital mortality among critically ill adults. The study includes all adult patients admitted in 2024 to the ICU Ward B at the Silesian Center for Heart Diseases (SCCS) in Zabrze. Researchers will analyze retrospective clinical and laboratory data from electronic medical records, including lab values collected at ICU admission, patient demographics, diagnoses, and outcomes. The biomarker ratios will be manually calculated in Excel and statistically evaluated. The main goal is to assess whether these ratios are associated with patient survival and to identify predictive cut-off values to support early risk stratification in the ICU setting.

Conditions

Sepsis; Respiratory Failure; Cardiac Arrest; Circulatory Failure; Critical Illness; Sudden Cardiac Arrest

Keywords

LAR; CAR; PAR; ICU; mortality; prediction

Outcome Measures

Primary Outcomes (1)

• In-hospital mortality

  All-cause in-hospital mortality among ICU patients during the index hospitalization.

  100 days from the date of ICU admission

Study Arms (2)

Survivors

Critically ill adult patients admitted to the ICU who survived hospitalization and were discharged alive.

Non-Survivors

Critically ill adult patients admitted to the ICU who died during the course of hospitalization.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the ICU. Data collected retrospectively from clinical records (AMMS system).

You may qualify if:

• Age ≥ 18 years
• Admission to ICU in 2024
• Availability of data for lactate, CRP, procalcitonin, and albumin

You may not qualify if:

• Missing outcome data (e.g. unknown survival status)
• Lack of laboratory parameters necessary for ratio calculation

Sponsors & Collaborators

• Medical University of Silesia: lead

Study Sites (1)

Department of Acute Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland

Zabrze, Silesian Voivodeship, 41-800, Poland

Location

MeSH Terms

Conditions

Sepsis; Respiratory Insufficiency; Heart Arrest; Shock; Critical Illness; Death, Sudden, Cardiac

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Respiratory Tract Diseases; Heart Diseases; Cardiovascular Diseases; Disease Attributes; Death, Sudden; Death

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 15, 2025
• First Posted: November 21, 2025
• Study Start: March 21, 2025
• Primary Completion: July 25, 2025
• Study Completion: September 20, 2025
• Last Updated: November 21, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)