Noninvasive Intratumor Heterogeneity Evaluation in HNSCC

NCT07027280 | Recruiting

• 1 other identifier: xChen
• Study Type: observational
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

This study focuses on tumor heterogeneity, a core challenge in the field of oncology, and innovatively utilizes patient imaging data to deeply mine and analyze intratumoral heterogeneity. By constructing an imaging analysis model for tumor heterogeneity and associating this model with clinical, pathological, transcriptomic, and metabolomic data of patients, a multi-omics decoding of tumor heterogeneity is achieved. The main questions it aims to address are: Can the ITH model stratify patients' treatment efficacy and prognosis assessment? Can pathological and multi-omics sequencing map the mechanisms behind the ITH model?

Conditions

Head and Neck Cancer

Outcome Measures

Primary Outcomes (2)

• AUC

  through study completion, an average of 1 year

• C-index

  through study completion, an average of 1 year

Study Arms (3)

Training set

Test set

Pathological set

Eligibility Criteria

• Age: 15 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with pathologically confirmed HNSCC were collected from the Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University.

You may qualify if:

• Pathologically confirmed head and neck squamous cell carcinoma (HNSCC). Complete clinical, imaging, and pathological data. Available complete follow-up information.

You may not qualify if:

• Patients who received chemotherapy or radiotherapy before surgery. Poor image quality. Tumors too small to be easily identified. History of other concurrent malignant tumors.

Sponsors & Collaborators

• First Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

RECRUITING

MeSH Terms

Conditions

Head and Neck Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms

Central Study Contacts

xinwei Chen

CONTACT

+8615178870590; cxw9977@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PHD

Study Record Dates

• First Submitted: June 10, 2025
• First Posted: June 18, 2025
• Study Start: February 27, 2025
• Primary Completion: June 15, 2025
• Study Completion: August 15, 2025
• Last Updated: June 18, 2025

Record last verified: 2025-06

Locations

CN (1)