Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC

NCT06345287 | Recruiting Phase 2

• 1 other identifier: 24/018-4298
• Study Type: interventional
• Target: 133
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to develop an adaptive radiation therapy plan for locally advanced head and neck squamous cell carcinoma receiving induction therapy containing immunotherapy and chemotherapy. The therapy plan is based on clinical remission, in order to reduce treatment-related toxic side effects without sacrificing clinical efficacy and improve the quality of life of patients.

Conditions

Head and Neck Cancer

Keywords

radical radiotherapy; induction immunotherapy and chemotherapy

Outcome Measures

Primary Outcomes (1)

• Progression-free survival

  defined as the time from random assignment to documented local or regional relapse, distant metastasis, or death from any cause, whichever occurred first after 2 years of treatment

  2 years

Secondary Outcomes (4)

• Overall survival

  2 years

• Deep partial response

  2 years

• Local-Regional failure survival

  2 years

• Toxicity Adverse events

  2 years

Study Arms (3)

clinical complete response

EXPERIMENTAL

radiotherapy 60Gy + concurrent chemotherapy + immunotherapy maintenance

Radiation: radical radiotherapy (60Gy); Combination Product: anti-PD-1 or PD-L1 antibody

deep partial response

EXPERIMENTAL

radiotherapy 66Gy + concurrent chemotherapy + immunotherapy maintenance

Radiation: radical radiotherapy (66Gy); Combination Product: anti-PD-1 or PD-L1 antibody

non-deep partial response

EXPERIMENTAL

radiotherapy 70Gy+ concurrent chemotherapy + immunotherapy maintenance

Radiation: radical radiotherapy (70Gy); Combination Product: anti-PD-1 or PD-L1 antibody

Interventions

radical radiotherapy (60Gy) RADIATION

concurrent chemoradiotherapy (60Gy) after induction therapy

clinical complete response

radical radiotherapy (66Gy) RADIATION

concurrent chemoradiotherapy (66Gy) after induction therapy

deep partial response

radical radiotherapy (70Gy) RADIATION

concurrent chemoradiotherapy (70Gy) after induction therapy

non-deep partial response

anti-PD-1 or PD-L1 antibody COMBINATION_PRODUCT

immunotherapy maintenance with anti-PD-1 or PDL1antibody every three weeks for 1 year after radiotherapy

clinical complete response; deep partial response; non-deep partial response

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Head and neck squamous cell carcinoma patients who undergo 2-4 cycles of induction chemotherapy and immunotherapy and plan to undergo radical radiotherapy treatment ( after MDT evaluation and communication with the patient, surgery is not recommended to preserve organ function, or the patient refuses surgery );
• Age range from 18 to 75 years old;
• Squamous cell carcinoma of the head and neck confirmed by pathological tissue biopsy;
• Clinical staging is T1-2N2-3M0, T3-4N0-3M0 (AJCC 8th edition);
• HPV or P16 (-);
• ECOG score 0-1 points;
• No contraindications to immunotherapy and radiotherapy;
• The functional level of the main organs meets the following standards:1) The blood routine examination standards need to meet: WBC ≥ 3.0 × 109/L, ANC ≥ 2.0 × 109/L, PLT ≥ 100 × 109/L, HGB ≥ 90g/L (no blood transfusion or blood products within 14 days, no use of G-CSF or other hematopoietic stimulating factors correction);2) Biochemical examination must meet the following standards: TBIL ≤ 2.0 × ULN, ALT, AST ≤ 2.5 × ULN, BUN and CRE ≤ 1.5 × ULN, or endogenous creatinine clearance rate ≥ 60ml/min (Cockcroft Gout formula);3) Good coagulation function: defined as international standardized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN; If the subject is receiving anticoagulant treatment, as long as the PT is within the intended range of use of the anticoagulant drug;4) The myocardial enzyme spectrum is within the normal range;
• Women of childbearing age must have taken reliable contraceptive measures, or have undergone pregnancy tests (serum or urine) within 7 days before enrollment, and the results are negative. They must be willing to use effective methods of contraception during the treatment period and within 2 months thereafter. For male participants whose partners are women of childbearing age, effective methods of contraception should be used during and within 2 months after treatment;
• Voluntarily participate in this study, sign an informed consent form, have good compliance, and cooperate with follow-up.

You may not qualify if:

• Previous or concurrent incurable malignant tumors in other parts, except cured skin basal cell carcinoma, cervical carcinoma in situ, thyroid papillary carcinoma and superficial bladder cancer;
• Suffering from any active autoimmune disease or having a history of autoimmune diseases (such as interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism (can be included after normal hormone replacement therapy); Asthma patients who suffer from vitiligo or have completely relieved childhood asthma and do not require any intervention in adulthood can be included, while asthma patients who require medical intervention with bronchodilators cannot be included;
• Suffering from uncontrolled cardiovascular diseases: Grade II or above myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval ≥ 470 ms); According to NYHA standards, patients with grade III-IV cardiac dysfunction or those with left ventricular ejection fraction (LVEF)\<50% indicated by echocardiography; Have experienced myocardial infarction within one year;
• Active infection or unexplained fever exceeding 38.5 ℃ during screening or before first administration (according to the researcher's judgment, subjects with fever caused by tumors can be included in the study);
• People with congenital or acquired immune deficiency (such as HIV infected people), active hepatitis B (HBV-DNA ≥ 104 copies/ml) or hepatitis C (hepatitis C antibody is positive, and HCR-RNA is higher than the detection limit of the analytical method);
• Previously received other PD-1 antibody treatments or other immunotherapies targeting PD-1/PD-L1;
• Known to be allergic to cisplatin, macromolecular protein preparations, or any anti PD-1 antibody component;
• If the subject undergoes major surgery without tumor treatment, the toxic reactions and/or complications caused by the surgical intervention must be fully recovered before starting treatment;
• Pregnant or lactating women;
• In the investigator's judgment, the subjects had other factors that might have led to their forced discontinuation of the study, such as other serious medical conditions (including mental illness) requiring concomitant treatment, serious abnormalities in laboratory test values, or family or social factors that might have affected the safety of the subjects or the circumstances of the trial data collection.

Sponsors & Collaborators

• Cancer Institute and Hospital, Chinese Academy of Medical Sciences: lead

Study Sites (1)

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, CAMS & PUMC

Beijing, China

RECRUITING

MeSH Terms

Conditions

Head and Neck Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms

Study Officials

• Junlin Yi, Doctor

  National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, CAMS & PUMC

  STUDY CHAIR

Central Study Contacts

Yang Meng

CONTACT

13359595417; YangMeng@pumc.edu.cn

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2024
• First Posted: April 3, 2024
• Study Start: January 1, 2024
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 3, 2024

Record last verified: 2024-01

Locations

CN (1)