A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
AZURE-Outcomes
A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in Patients With Established Atherosclerotic Cardiovascular Disease (ASCVD) or at High Risk for a First ASCVD Event
2 other identifiers
interventional
15,100
36 countries
1264
Brief Summary
The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs placebo on the risk of MACE-PLUS will be evaluated from randomisation until the primary analysis censoring date (PACD). The Study Closure Visit will be scheduled to occur after the PACD and will be the final visit for each participant in the study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jun 2025
Typical duration for phase_3
1264 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 30, 2025
CompletedFirst Posted
Study publicly available on registry
June 2, 2025
CompletedStudy Start
First participant enrolled
June 4, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 26, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 26, 2029
April 17, 2026
April 1, 2026
4.4 years
May 30, 2025
April 16, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to first event of any component of MACE-PLUS
To compare the effect of treatment with AZD0780 to placebo in reducing the risk of MACE-PLUS (the composite of CV death, myocardial infarction \[MI\], ischaemic stroke, acute lower limb ischaemia, major amputation of a vascular aetiology, and urgent arterial revascularisation)
Up to approximately 54 months
Secondary Outcomes (7)
Time to first event of any component of 3P MACE
Up to approximately 54 months
Time to first event of any component of MACE PLUS
Up to approximately 54 months
Time to first event of MI
Up to approximately 54 months
Time to first event of urgent coronary revascularisation
Up to approximately 54 months
Time to CV death
Up to approximately 54 months
- +2 more secondary outcomes
Study Arms (2)
AZD0780
EXPERIMENTALParticipants will receive oral AZD0780 once daily
Placebo
PLACEBO COMPARATORParticipants will receive oral placebo once daily
Interventions
Eligibility Criteria
You may qualify if:
- Meets one of the following:
- Participants with history of an ASCVD event: Participants ≥ 18 years of age at the time of signing the ICF with a history of MI or ischaemic stroke suspected to be due to atherosclerotic vascular disease ≥ 1 month prior to randomisation (presumed lacunar or cardioembolic strokes are not qualifying events), or revascularisation for symptomatic lower limb PAD any time prior to screening
- Additional risk factors based on the level of the LDL-C and timing of MI or stroke:
- o Participants with an LDL-C ≥ 75 mg/dL (≥ 1.9 mmol/L) need to have at least one of the other additional risk factors (i to viii) below.
- ii) T2DM requiring ongoing medical therapy iii) Age ≥ 65 years v) Previous above ankle amputation due to PAD vi) Previous diagnosis of non-end stage CKD
- Participants at increased risk of a first ASCVD event: Male participant ≥ 50 years of age or female participant ≥ 55 years of age at the time of signing the ICF with LDL-C ≥ 100 mg/dL (≥ 2.6 mmol/L), with no prior history of MI, ischaemic stroke due to atherosclerotic disease, or leg revascularisation for symptomatic lower limb PAD, and with diagnostic evidence of at least one of the following disease categories (i, ii, or iii):
- (i) Significant atherosclerotic artery disease (ii) High-risk Type 1 or Type 2 diabetes mellitus with manifestation of at least one of the following end-organ diseases:
- Nephropathy - Persistent (≥ 2 readings) microalbuminuria (urine albumin/creatinine ratio ≥ 30 mg/g) and/or persistent eGFR \< 60 mL/min/1.73 m2. At least one reading must come from the medical record within the last 12 months in addition to the reading from screening
- Retinopathy - Treated diabetic retinopathy (surgical intervention or injectable therapy) or prior diagnosis made by a relevant healthcare specialist
- Neuropathy - Treated neuropathy (medical therapy for pain relief or symptom alleviation) or prior diagnosis made by a relevant healthcare specialist
- ABI \< 0.9 or \> 1.4 - confirmed either in study during screening or randomisation, or from the medical record within the last 5 years (iii) Documented atherosclerosis of less significance
- For (ii) and (iii), participants need to have at least one of the additional risk factors below:
- <!-- -->
- CKD with eGFR x mL/min/1.73 m2
- Current tobacco use
- +4 more criteria
You may not qualify if:
- Any underlying known disease, or condition including homozygous familial hypercholesterolaemia, or LDL or plasma apheresis within 12 months prior to randomisation, that, in the opinion of the investigator, might interfere with the interpretation of the clinical study results.
- Any revascularisation procedure planned within the next 3 months.
- Available imaging assessment within the last 3 years showing either coronary calcium score of zero, or a coronary computed tomography angiography with no atherosclerosis.
- Calculated eGFR \< 15 mL /min/1.73 m2 at screening.
- Any laboratory values with the following deviations at screening:
- AST or ALT \> 3 × ULN
- TBL \> 2 × ULN (except for participants with Gilbert's syndrome where TBL 3 × ULN is acceptable provided direct bilirubin \< 1.5 × ULN)
- Fasting triglycerides ≥ 400 mg/dL (≥ 4.52 mmol/L).
- Creatine kinase \> 5 × ULN
- Urine albumin/creatinine ratio ≥ 500 mg/g
- Uncontrolled T2DM defined as HbA1c ≥ 9.5% at screening.
- Inadequately treated hypothyroidism defined as TSH \> 1.5 × ULN at screening or participants whose thyroid replacement therapy was initiated or modified within the last 3 months prior to screening.
- Use of mipomersen or lomitapide (cholesterol-lowering medications) within 12 months of screening or planned use during the study.
- Use of gemfibrozil within one week prior to the Screening Visit or planned use during the study.
- Use of PCSK9 inhibitors: evolocumab/alirocumab within 12 weeks of the Screening Visit or planned use during the study, or inclisiran within 18 months of the Screening Visit or planned use during the study, or any other approved PCSK9 inhibitor use within 5 half lives prior to the Screening Visit or planned use during the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (1264)
Research Site
Birmingham, Alabama, 35205, United States
Research Site
Fairhope, Alabama, 36532, United States
Research Site
Foley, Alabama, 36535, United States
Research Site
Huntsville, Alabama, 35801, United States
Research Site
Mobile, Alabama, 36608, United States
Research Site
Saraland, Alabama, 36571, United States
Research Site
Vestavia Hills, Alabama, 35216, United States
Research Site
Gilbert, Arizona, 85296, United States
Research Site
Glendale, Arizona, 85308, United States
Research Site
Mesa, Arizona, 85206, United States
Research Site
Peoria, Arizona, 85382, United States
Research Site
Phoenix, Arizona, 85014, United States
Research Site
Phoenix, Arizona, 85051, United States
Research Site
Phoenix, Arizona, 85053, United States
Research Site
Scottsdale, Arizona, 85260, United States
Research Site
Tempe, Arizona, 85283, United States
Research Site
Tucson, Arizona, 85715, United States
Research Site
Tucson, Arizona, 85741, United States
Research Site
Tucson, Arizona, 85745, United States
Research Site
Beverly Hills, California, 90211, United States
Research Site
Canoga Park, California, 91303, United States
Research Site
Castroville, California, 95012, United States
Research Site
Chula Vista, California, 91911, United States
Research Site
Fountain Valley, California, 92708, United States
Research Site
Garden Grove, California, 92844, United States
Research Site
La Jolla, California, 92037, United States
Research Site
Lake Forest, California, 92630, United States
Research Site
Lancaster, California, 93534, United States
Research Site
Loma Linda, California, 92350, United States
Research Site
Loma Linda, California, 92357, United States
Research Site
Los Angeles, California, 90017, United States
Research Site
Los Angeles, California, 90035, United States
Research Site
Lynwood, California, 90262, United States
Research Site
Monterey Park, California, 91754, United States
Research Site
Newport Beach, California, 92663, United States
Research Site
Norco, California, 92860, United States
Research Site
Northridge, California, 91325, United States
Research Site
Pomona, California, 91768, United States
Research Site
Poway, California, 92064, United States
Research Site
Riverside, California, 92503, United States
Research Site
Sacramento, California, 95817, United States
Research Site
San Diego, California, 92111, United States
Research Site
San Dimas, California, 91773, United States
Research Site
Santa Ana, California, 92705, United States
Research Site
Stanford, California, 94305, United States
Research Site
Tarzana, California, 91356, United States
Research Site
Thousand Oaks, California, 91360, United States
Research Site
Torrance, California, 90502, United States
Research Site
West Hills, California, 91307, United States
Research Site
Stamford, Connecticut, 06905, United States
Research Site
Waterbury, Connecticut, 06708, United States
Research Site
Boca Raton, Florida, 33486, United States
Research Site
Clearwater, Florida, 33756, United States
Research Site
Coral Gables, Florida, 33134, United States
Research Site
Crystal River, Florida, 34429, United States
Research Site
DeLand, Florida, 32720, United States
Research Site
Fleming Island, Florida, 32003, United States
Research Site
Fort Lauderdale, Florida, 33308, United States
Research Site
Fort Lauderdale, Florida, 33316, United States
Research Site
Gainesville, Florida, 32608, United States
Research Site
Gainesville, Florida, 32610, United States
Research Site
Hallandale, Florida, 33009, United States
Research Site
Hialeah, Florida, 33012, United States
Research Site
Hialeah, Florida, 33012, United States
Research Site
Hollywood, Florida, 33021, United States
Research Site
Homestead, Florida, 33030, United States
Research Site
Inverness, Florida, 34452, United States
Research Site
Jacksonville, Florida, 32204, United States
Research Site
Jacksonville, Florida, 32205, United States
Research Site
Jacksonville, Florida, 32209, United States
Research Site
Jacksonville, Florida, 32216, United States
Research Site
Lake City, Florida, 32055, United States
Research Site
Lake Worth, Florida, 33462, United States
Research Site
Lakeland, Florida, 33805, United States
Research Site
Lakeland, Florida, 33813, United States
Research Site
Largo, Florida, 33777, United States
Research Site
Longwood, Florida, 32750, United States
Research Site
Maitland, Florida, 32751, United States
Research Site
Margate, Florida, 33063, United States
Research Site
Miami, Florida, 33176, United States
Research Site
Miami, Florida, 33186, United States
Research Site
Miami, Florida, 33269, United States
Research Site
Miami Lakes, Florida, 33014, United States
Research Site
Miami Lakes, Florida, 33016, United States
Research Site
Naples, Florida, 34102, United States
Research Site
New Port Richey, Florida, 34652, United States
Research Site
New Port Richey, Florida, 34653, United States
Research Site
Ocala, Florida, 34470, United States
Research Site
Orlando, Florida, 32801, United States
Research Site
Orlando, Florida, 32807, United States
Research Site
Orlando, Florida, 32825, United States
Research Site
Palm Harbor, Florida, 34684, United States
Research Site
Palmetto Bay, Florida, 33157, United States
Research Site
Pembroke Pines, Florida, 33029, United States
Research Site
Port Charlotte, Florida, 33952, United States
Research Site
Port Charlotte, Florida, 33952, United States
Research Site
Safety Harbor, Florida, 34695, United States
Research Site
Saint Augustine, Florida, 32086, United States
Research Site
Seminole, Florida, 33777, United States
Research Site
Tampa, Florida, 33625, United States
Research Site
West Palm Beach, Florida, 33401, United States
Research Site
Atlanta, Georgia, 30322, United States
Research Site
Atlanta, Georgia, 30328, United States
Research Site
Atlanta, Georgia, 30342, United States
Research Site
Canton, Georgia, 30114, United States
Research Site
Decatur, Georgia, 30030, United States
Research Site
Decatur, Georgia, 30033, United States
Research Site
Hinesville, Georgia, 31313, United States
Research Site
Macon, Georgia, 31210, United States
Research Site
Peachtree Corners, Georgia, 30092, United States
Research Site
Riverdale, Georgia, 30274, United States
Research Site
Stockbridge, Georgia, 30281, United States
Research Site
Tucker, Georgia, 30084, United States
Research Site
Union City, Georgia, 30291, United States
Research Site
Woodstock, Georgia, 30189, United States
Research Site
Chicago, Illinois, 60607, United States
Research Site
Gurnee, Illinois, 60031, United States
Research Site
Melrose Park, Illinois, 60160, United States
Research Site
Tinley Park, Illinois, 60477, United States
Research Site
Winfield, Illinois, 60190, United States
Research Site
Carmel, Indiana, 46290, United States
Research Site
Evansville, Indiana, 47714, United States
Research Site
Evansville, Indiana, 47715, United States
Research Site
Munster, Indiana, 46321, United States
Research Site
Ames, Iowa, 50010, United States
Research Site
Waterloo, Iowa, 50701, United States
Research Site
West Des Moines, Iowa, 50266, United States
Research Site
Kansas City, Kansas, 66112, United States
Research Site
Kansas City, Kansas, 66160, United States
Research Site
Wichita, Kansas, 67218, United States
Research Site
Bowling Green, Kentucky, 42101, United States
Research Site
Lexington, Kentucky, 40503, United States
Research Site
Owensboro, Kentucky, 42301, United States
Research Site
Paducah, Kentucky, 42001, United States
Research Site
Versailles, Kentucky, 40383, United States
Research Site
Bossier City, Louisiana, 71111, United States
Research Site
Covington, Louisiana, 70433, United States
Research Site
Hammond, Louisiana, 70403, United States
Research Site
Lake Charles, Louisiana, 70601, United States
Research Site
Shreveport, Louisiana, 71105, United States
Research Site
Zachary, Louisiana, 70791, United States
Research Site
Bangor, Maine, 04401, United States
Research Site
Scarborough, Maine, 04074, United States
Research Site
Annapolis, Maryland, 21401, United States
Research Site
Baltimore, Maryland, 21229, United States
Research Site
Beltsville, Maryland, 20705, United States
Research Site
Columbia, Maryland, 21044, United States
Research Site
Lanham, Maryland, 20706, United States
Research Site
Oxon Hill, Maryland, 20745, United States
Research Site
Pikesville, Maryland, 21208, United States
Research Site
Rockville, Maryland, 20850, United States
Research Site
Boston, Massachusetts, 02111, United States
Research Site
Brookline, Massachusetts, 02446, United States
Research Site
Haverhill, Massachusetts, 01830, United States
Research Site
Dearborn Heights, Michigan, 48127, United States
Research Site
Detroit, Michigan, 48202, United States
Research Site
Farmington Hills, Michigan, 48336, United States
Research Site
Southfield, Michigan, 48034, United States
Research Site
Southfield, Michigan, 48076, United States
Research Site
Ypsilanti, Michigan, 48197, United States
Research Site
Duluth, Minnesota, 55805, United States
Research Site
Minneapolis, Minnesota, 55423, United States
Research Site
Minneapolis, Minnesota, 55435, United States
Research Site
Saint Cloud, Minnesota, 56303, United States
Research Site
Bridgeton, Missouri, 63044, United States
Research Site
Chesterfield, Missouri, 63005, United States
Research Site
Hazelwood, Missouri, 63042, United States
Research Site
Jefferson City, Missouri, 65109, United States
Research Site
Kansas City, Missouri, 64128, United States
Research Site
Kansas City, Missouri, 64151, United States
Research Site
Springfield, Missouri, 65807, United States
Research Site
St Louis, Missouri, 63110, United States
Research Site
St Louis, Missouri, 63119, United States
Research Site
Missoula, Montana, 59808, United States
Research Site
Elkhorn, Nebraska, 68022, United States
Research Site
Fremont, Nebraska, 68025, United States
Research Site
Omaha, Nebraska, 68144, United States
Research Site
Henderson, Nevada, 89014, United States
Research Site
Las Vegas, Nevada, 89102, United States
Research Site
Las Vegas, Nevada, 89119, United States
Research Site
Las Vegas, Nevada, 89128, United States
Research Site
Lebanon, New Hampshire, 03756, United States
Research Site
Bridgewater, New Jersey, 08807, United States
Research Site
Somerset, New Jersey, 08873, United States
Research Site
Brooklyn, New York, 11201, United States
Research Site
Buffalo, New York, 14217, United States
Research Site
Laurelton, New York, 11413, United States
Research Site
New York, New York, 10029, United States
Research Site
The Bronx, New York, 10451, United States
Research Site
Asheville, North Carolina, 28803, United States
Research Site
Chapel Hill, North Carolina, 27599, United States
Research Site
Durham, North Carolina, 27701, United States
Research Site
Durham, North Carolina, 27705, United States
Research Site
Greensboro, North Carolina, 27408, United States
Research Site
Monroe, North Carolina, 28112, United States
Research Site
Morehead City, North Carolina, 28557, United States
Research Site
Morganton, North Carolina, 28655, United States
Research Site
New Bern, North Carolina, 28562, United States
Research Site
Wilmington, North Carolina, 28401, United States
Research Site
Winston-Salem, North Carolina, 27157, United States
Research Site
Fargo, North Dakota, 58104, United States
Research Site
Cincinnati, Ohio, 45220, United States
Research Site
Columbus, Ohio, 43213, United States
Research Site
Dublin, Ohio, 43016, United States
Research Site
Lima, Ohio, 45805, United States
Research Site
Maumee, Ohio, 43537, United States
Research Site
Munroe Falls, Ohio, 44262, United States
Research Site
Norman, Oklahoma, 73069, United States
Research Site
Portland, Oregon, 97210, United States
Research Site
Camp Hill, Pennsylvania, 17011, United States
Research Site
Duncansville, Pennsylvania, 16635, United States
Research Site
Horsham, Pennsylvania, 19044, United States
Research Site
Philadelphia, Pennsylvania, 19114, United States
Research Site
Smithfield, Pennsylvania, 15478, United States
Research Site
West Chester, Pennsylvania, 19380, United States
Research Site
Wilkes-Barre, Pennsylvania, 18711, United States
Research Site
Yardley, Pennsylvania, 19067, United States
Research Site
Providence, Rhode Island, 02908, United States
Research Site
Charleston, South Carolina, 29402, United States
Research Site
Fort Mill, South Carolina, 29707, United States
Research Site
Mauldin, South Carolina, 29662, United States
Research Site
Myrtle Beach, South Carolina, 29572, United States
Research Site
North Charleston, South Carolina, 29405, United States
Research Site
North Charleston, South Carolina, 29406, United States
Research Site
Rapid City, South Dakota, 57701, United States
Research Site
Chattanooga, Tennessee, 37404, United States
Research Site
Chattanooga, Tennessee, 37421, United States
Research Site
Elizabethton, Tennessee, 37643, United States
Research Site
Knoxville, Tennessee, 37849, United States
Research Site
Knoxville, Tennessee, 37912, United States
Research Site
Knoxville, Tennessee, 37938, United States
Research Site
Memphis, Tennessee, 38119, United States
Research Site
Memphis, Tennessee, 38128, United States
Research Site
Morristown, Tennessee, 37813, United States
Research Site
Nashville, Tennessee, 37232, United States
Research Site
Tullahoma, Tennessee, 37388, United States
Research Site
Amarillo, Texas, 79106, United States
Research Site
Beaumont, Texas, 77706, United States
Research Site
Brownsville, Texas, 78526, United States
Research Site
Corpus Christi, Texas, 78404, United States
Research Site
Dallas, Texas, 75216, United States
Research Site
Dallas, Texas, 75234, United States
Research Site
Dallas, Texas, 75246, United States
Research Site
DeSoto, Texas, 75115, United States
Research Site
El Paso, Texas, 79902, United States
Research Site
El Paso, Texas, 79905, United States
Research Site
Euless, Texas, 76040, United States
Research Site
Houston, Texas, 77002, United States
Research Site
Houston, Texas, 77025, United States
Research Site
Houston, Texas, 77034, United States
Research Site
Houston, Texas, 77043, United States
Research Site
Houston, Texas, 77087, United States
Research Site
Humble, Texas, 77338, United States
Research Site
Irving, Texas, 75061, United States
Research Site
Katy, Texas, 77450, United States
Research Site
Kingwood, Texas, 77339, United States
Research Site
Kingwood, Texas, 77345, United States
Research Site
McAllen, Texas, 78503, United States
Research Site
McKinney, Texas, 75069, United States
Research Site
Mesquite, Texas, 75149, United States
Research Site
Paris, Texas, 75462, United States
Research Site
Pearland, Texas, 77584, United States
Research Site
Pharr, Texas, 78577, United States
Research Site
Plano, Texas, 75093, United States
Research Site
San Antonio, Texas, 78207, United States
Research Site
San Antonio, Texas, 78212, United States
Research Site
Sugar Land, Texas, 77478, United States
Research Site
Sugar Land, Texas, 77479, United States
Research Site
Temple, Texas, 76508, United States
Research Site
Tomball, Texas, 77375, United States
Research Site
Tyler, Texas, 75701, United States
Research Site
Victoria, Texas, 77901, United States
Research Site
Bountiful, Utah, 84010, United States
Research Site
Ogden, Utah, 84404, United States
Research Site
Ogden, Utah, 84405, United States
Research Site
Roy, Utah, 84067, United States
Research Site
Salt Lake City, Utah, 84124, United States
Research Site
Salt Lake City, Utah, 84148, United States
Research Site
White River Junction, Vermont, 05001, United States
Research Site
Charlottesville, Virginia, 22911, United States
Research Site
Fairfax, Virginia, 22031, United States
Research Site
Falls Church, Virginia, 22042, United States
Research Site
Henrico, Virginia, 23229, United States
Research Site
Hopewell, Virginia, 23860, United States
Research Site
Manassas, Virginia, 20110, United States
Research Site
Newport News, Virginia, 23606, United States
Research Site
Norfolk, Virginia, 23504, United States
Research Site
Richmond, Virginia, 23219, United States
Research Site
Suffolk, Virginia, 23435, United States
Research Site
Redmond, Washington, 98052, United States
Research Site
Renton, Washington, 98057, United States
Research Site
Seattle, Washington, 98122, United States
Research Site
Tacoma, Washington, 98405, United States
Research Site
Morgantown, West Virginia, 26505, United States
Research Site
Milwaukee, Wisconsin, 64111, United States
Research Site
CABA, C1025ABI, Argentina
Research Site
CABA, C1426, Argentina
Research Site
Capital Federal, C1014A, Argentina
Research Site
Ciudad Autonoma de Bs As, C1023AAB, Argentina
Research Site
Ciudad de Buenos Aires, 1128, Argentina
Research Site
Ciudad de Buenos Aires, C1019ABS, Argentina
Research Site
Ciudad de Buenos Aires, C1094AAD, Argentina
Research Site
Ciudad de Buenos Aires, C1425AGC, Argentina
Research Site
Ciudad de Buenos Aires, C1428DCO, Argentina
Research Site
Ciudad de Rosario, S2000, Argentina
Research Site
Córdoba, 5000, Argentina
Research Site
Córdoba, X5003DCE, Argentina
Research Site
Córdoba, X5008HHW, Argentina
Research Site
Godoy Cruz, M5501ARP, Argentina
Research Site
Lanús Este, B1824KAJ, Argentina
Research Site
Mar del Plata, 7600, Argentina
Research Site
Nueva Córdoba, X5000JJS, Argentina
Research Site
Rosario, 2000, Argentina
Research Site
Rosario, 2123, Argentina
Research Site
Rosario, S2000CVD, Argentina
Research Site
Rosario, S2000PBJ, Argentina
Research Site
San Juan, 5400, Argentina
Research Site
San Miguel de Tucumán, T4000ICL, Argentina
Research Site
San Nicolás, B2900DMH, Argentina
Research Site
Santa Rosa, 6300, Argentina
Research Site
Zárate, 2800, Argentina
Research Site
Aracaju, 49015-380, Brazil
Research Site
Barretos, 14784-400, Brazil
Research Site
Belém, 66073-005, Brazil
Research Site
Belo Horizonte, 30110-934, Brazil
Research Site
Belo Horizonte, 30150-250, Brazil
Research Site
Belo Horizonte, 30150-270, Brazil
Research Site
Blumenau, 89020-430, Brazil
Research Site
Brasília, 70200-730, Brazil
Research Site
Brasília, 71625-009, Brazil
Research Site
Brasília, 72145-450, Brazil
Research Site
Campina Grande do Sul, 83.430-000, Brazil
Research Site
Campinas, 13060-080, Brazil
Research Site
Campinas, 13060-904, Brazil
Research Site
Campinas, 13083-887, Brazil
Research Site
Campinas, 13092133, Brazil
Research Site
Criciúma, 88811-000, Brazil
Research Site
Curitiba, 80045-170, Brazil
Research Site
Curitiba, 80230-130, Brazil
Research Site
Curitiba, 80730-150, Brazil
Research Site
Goiânia, 74605-020, Brazil
Research Site
Juiz de Fora, 36033-318, Brazil
Research Site
Marília, 17515000, Brazil
Research Site
Natal, 59020-035, Brazil
Research Site
Ponta Grossa, 84010-200, Brazil
Research Site
Porto Alegre, 9061-000, Brazil
Research Site
Porto Alegre, 90620-001, Brazil
Research Site
Porto Alegre, 90630-165, Brazil
Research Site
Porto Alegre, 91350-280, Brazil
Research Site
Recife, 52051-380, Brazil
Research Site
Rio de Janeiro, 20241-180, Brazil
Research Site
São Caetano do Sul, 09521-160, Brazil
Research Site
São José do Rio Preto, 15090-000, Brazil
Research Site
São José dos Campos, 12230-001, Brazil
Research Site
São Paulo, 04004-030, Brazil
Research Site
São Paulo, 04012-180, Brazil
Research Site
São Paulo, 04014-002, Brazil
Research Site
São Paulo, 04026-090, Brazil
Research Site
São Paulo, 05403-000, Brazil
Research Site
Tatuí, 18270-170, Brazil
Research Site
Teresina, 64001-450, Brazil
Research Site
Uberlândia, 38400-500, Brazil
Research Site
Vila Velha, 29118-060, Brazil
Research Site
Botevgrad, 2140, Bulgaria
Research Site
Haskovo, 6304, Bulgaria
Research Site
Pernik, 2300, Bulgaria
Research Site
Plovdiv, 4000, Bulgaria
Research Site
Plovdiv, 4002, Bulgaria
Research Site
Plovdiv, 4003, Bulgaria
Research Site
Plovdiv, 4004, Bulgaria
Research Site
Sliven, 8800, Bulgaria
Research Site
Sofia, 1000, Bulgaria
Research Site
Sofia, 1431, Bulgaria
Research Site
Sofia, 1527, Bulgaria
Research Site
Sofia, 1618, Bulgaria
Research Site
Stara Zagora, 6000, Bulgaria
Research Site
Red Deer, Alberta, T4P 1K4, Canada
Research Site
Richmond, British Columbia, V6V 2L1, Canada
Research Site
Vancouver, British Columbia, V6Z2H2, Canada
Research Site
Victoria, British Columbia, V8R 1B2, Canada
Research Site
Victoria, British Columbia, V8T 5G4, Canada
Research Site
Bridgewater, Nova Scotia, B4V 3N2, Canada
Research Site
Halifax, Nova Scotia, B3H 1V8, Canada
Research Site
Sydney, Nova Scotia, B1M 0A1, Canada
Research Site
Brampton, Ontario, L6S 0C6, Canada
Research Site
Cambridge, Ontario, N1R 6V6, Canada
Research Site
Hamilton, Ontario, L8L 5G4, Canada
Research Site
Kingston, Ontario, K7M 7E4, Canada
Research Site
Markham, Ontario, L3S 0A2, Canada
Research Site
Mississauga, Ontario, L5K2L3, Canada
Research Site
Newmarket, Ontario, L3Y 2P6, Canada
Research Site
North York, Ontario, M6B 3H7, Canada
Research Site
North York, Ontario, M9N 1W4, Canada
Research Site
Scarborough Village, Ontario, M1R 0B1, Canada
Research Site
Stoney Creek, Ontario, L8J 3W2, Canada
Research Site
Thunder Bay, Ontario, P7B 7C7, Canada
Research Site
Toronto, Ontario, M5G 2C4, Canada
Research Site
Toronto, Ontario, M6G 1M2, Canada
Research Site
Toronto, Ontario, M6N 1B5, Canada
Research Site
Montreal, Quebec, H3G 1A4, Canada
Research Site
Québec, Quebec, G1G 5X1, Canada
Research Site
Québec, Quebec, G1V 4G5, Canada
Research Site
Québec, Quebec, G1V 4T3, Canada
Research Site
Québec, Quebec, G3K 2P8, Canada
Research Site
Sherbrooke, Quebec, J1E 0N8, Canada
Research Site
Terrebonne, Quebec, J6V 2H2, Canada
Research Site
Trois-Rivières, Quebec, G9A 4P3, Canada
Research Site
Antofagasta, 1240000, Chile
Research Site
Chillan, 3800761, Chile
Research Site
Concepción, 4070196, Chile
Research Site
Independencia, 8380465, Chile
Research Site
Las Condes, 7560903, Chile
Research Site
Osorno, 5311092, Chile
Research Site
Santiago, 7500587, Chile
Research Site
Santiago, 7500710, Chile
Research Site
Santiago, 7770086, Chile
Research Site
Santiago, 8330034, Chile
Research Site
Santiago, 8331143, Chile
Research Site
Santiago, 8380456, Chile
Research Site
Santiago, 8910259, Chile
Research Site
Talcahuano, 4270918, Chile
Research Site
Valdivia, 5090000, Chile
Research Site
Victoria, 4720000, Chile
Research Site
Viña del Mar, 2520000, Chile
Research Site
Anyang, 455001, China
Research Site
Baotou, 014040, China
Research Site
Beijing, 100020, China
Research Site
Beijing, 100029, China
Research Site
Beijing, 100034, China
Research Site
Beijing, 100037, China
Research Site
Beijing, 100044, China
Research Site
Beijing, 100050, China
Research Site
Beijing, 100053, China
Research Site
Beijing, 100076, China
Research Site
Beijing, 100176, China
Research Site
Beijing, 102218, China
Research Site
Changchun, 130021, China
Research Site
Changde, 415000, China
Research Site
Changsha, 410004, China
Research Site
Changsha, 410005, China
Research Site
Changsha, 410011, China
Research Site
Changsha, 410013, China
Research Site
Chengdu, 610000, China
Research Site
Chengdu, 610021, China
Research Site
Chengdu, 610041, China
Research Site
Chifeng, 024000, China
Research Site
Daqing, 163316, China
Research Site
Foshan, 528200, China
Research Site
Guangzhou, 510000, China
Research Site
Guangzhou, 510080, China
Research Site
Guangzhou, 510100, China
Research Site
Guangzhou, 510280, China
Research Site
Guangzhou, 510620, China
Research Site
Guangzhou, 510665, China
Research Site
Haikou, 570311, China
Research Site
Hangzhou, 310003, China
Research Site
Hangzhou, 310016, China
Research Site
Ha’erbin, 150001, China
Research Site
Hefei, 230001, China
Research Site
Hefei, 230601, China
Research Site
Heze, 274099, China
Research Site
Hohhot, 010050, China
Research Site
Huaian, 223300, China
Research Site
Huangshi, 435000, China
Research Site
Huizhou, 516001, China
Research Site
Jiangmen, 529000, China
Research Site
Jinan, 250001, China
Research Site
Jinan, 250030, China
Research Site
Jining, 272006, China
Research Site
Jining, 272011, China
Research Site
Jinzhou Shi, 121001, China
Research Site
Lanzhou, 730000, China
Research Site
Lanzhou, 730030, China
Research Site
Linyi, CN-276003, China
Research Site
Lishui, 323000, China
Research Site
Liuchow, 545006, China
Research Site
Luoyang, 471001, China
Research Site
Luoyang, 471003, China
Research Site
Meihekou, 135022, China
Research Site
Meizhou, 514031, China
Research Site
Meizhou, 514700, China
Research Site
Nanchang, 330000, China
Research Site
Nanchang, 330006, China
Research Site
Nanjing, 2100008, China
Research Site
Nanjing, 210011, China
Research Site
Nanyang, 473000, China
Research Site
Neijiang, 641100, China
Research Site
Pinggu, 101200, China
Research Site
Shanghai, 200025, China
Research Site
Shanghai, 200032, China
Research Site
Shanghai, 200062, China
Research Site
Shanghai, 200080, China
Research Site
Shanghai, 200090, China
Research Site
Shantou, 515065, China
Research Site
Shaoguan Shi, 512025, China
Research Site
Shenyang, 110004, China
Research Site
Shenyang, 110016, China
Research Site
Shenzhen, 518020, China
Research Site
Siping, 136000, China
Research Site
Suining, 629000, China
Research Site
Suzhou, 215006, China
Research Site
Taian, 271099, China
Research Site
Tianjin, 300000, China
Research Site
Tianjin, 300140, China
Research Site
Tianjin, 300457, China
Research Site
Wanzhou, 404000, China
Research Site
Wuhan, 430010, China
Research Site
Xi'an, 710061, China
Research Site
Xi'an, 710068, China
Research Site
Xianyang, 712000, China
Research Site
Xinxiang, 453002, China
Research Site
Xuzhou, 221000, China
Research Site
Xuzhou, 221009, China
Research Site
Yangzhou, 225001, China
Research Site
Yueyang, 414000, China
Research Site
Yuncheng, 044099, China
Research Site
Zhanjiang, 524001, China
Research Site
Zhengzhou, 450007, China
Research Site
Zhengzhou, 450052, China
Research Site
Zhenjiang, 212002, China
Research Site
Zhuhai, 519000, China
Research Site
Zhuozhou, 072750, China
Research Site
Zibo, 255000, China
Research Site
Armenia, 630004, Colombia
Research Site
Barranquilla, 080020, Colombia
Research Site
Barranquilla, 80007, Colombia
Research Site
Barranquilla, 80020, Colombia
Research Site
Bogotá, 110131, Colombia
Research Site
Bogotá, 110221, Colombia
Research Site
Cali, 760036, Colombia
Research Site
Cartagena, 130001, Colombia
Research Site
Chía, 250002, Colombia
Research Site
Ibague, 730006, Colombia
Research Site
Medellín, 050021, Colombia
Research Site
Medellín, 050022, Colombia
Research Site
Medellín, 050030, Colombia
Research Site
Pasto, 520002, Colombia
Research Site
Benátky nad Jizerou, 294 71, Czechia
Research Site
Benešov, 256 01, Czechia
Research Site
Brno, 60 300, Czechia
Research Site
Brno, 602 00, Czechia
Research Site
Brno, 615 00, Czechia
Research Site
Brno, 62500, Czechia
Research Site
Brno, 638 00, Czechia
Research Site
Brno, 639 00, Czechia
Research Site
Broumov, 55001, Czechia
Research Site
Bruntál, 792 01, Czechia
Research Site
Česká Třebová, 560 02, Czechia
Research Site
České Budějovice, 370 01, Czechia
Research Site
Český Krumlov, 381 01, Czechia
Research Site
Hodonín, 695 01, Czechia
Research Site
Jaroměř, 551 01, Czechia
Research Site
Liberec, 460 01, Czechia
Research Site
Louny, 440 01, Czechia
Research Site
Ostrava, 702 00, Czechia
Research Site
Ostrava-Dubina, 700 30, Czechia
Research Site
Prague, 101 00, Czechia
Research Site
Prague, 110 00, Czechia
Research Site
Prague, 140 00, Czechia
Research Site
Prague, 147 00, Czechia
Research Site
Prague, 150 00, Czechia
Research Site
Prague, 150 06, Czechia
Research Site
Prague, 158 00, Czechia
Research Site
Prague, 19800, Czechia
Research Site
Pribram VIII, 261 01, Czechia
Research Site
Svitavy, 568 02, Czechia
Research Site
Tábor, 390 03, Czechia
Research Site
Třebíč, 674 01, Czechia
Research Site
Zlín, 760 01, Czechia
Research Site
Aarhus N, 8200, Denmark
Research Site
Copenhagen, 2300, Denmark
Research Site
Copenhagen, DK-2400, Denmark
Research Site
Esbjerg, 6700, Denmark
Research Site
Gandrup, 9362, Denmark
Research Site
Herlev, 2730, Denmark
Research Site
Herning, 7400, Denmark
Research Site
Hillerød, 3400, Denmark
Research Site
Hvidovre, DK-2650, Denmark
Research Site
Roskilde, 4000, Denmark
Research Site
Slagelse, DK-4200, Denmark
Research Site
Svendborg, 5700, Denmark
Research Site
Vejle, 7100, Denmark
Research Site
Viborg, 8800, Denmark
Research Site
Bordeaux, 33076, France
Research Site
Brest, 29609, France
Research Site
Bron, 69667, France
Research Site
Corbeil-Essonnes, 91100, France
Research Site
Dijon, 2100, France
Research Site
Dijon, 21079, France
Research Site
La Tronche, 38706, France
Research Site
Lille, 59037, France
Research Site
Limoges, 87042, France
Research Site
Lyon, 69007, France
Research Site
Marseille, 13009, France
Research Site
Montpellier, 34090, France
Research Site
Narbonne, 11108, France
Research Site
Paris, 75012, France
Research Site
Paris, 75651, France
Research Site
Paris, 75674, France
Research Site
Paris, 75877, France
Research Site
Paris, 75908, France
Research Site
Poitiers, 86021, France
Research Site
Rennes, 35033, France
Research Site
Rouen, 76031, France
Research Site
Strasbourg, 67098, France
Research Site
Toulouse, 31059, France
Research Site
Tours, 37044, France
Research Site
Valenciennes, 59300, France
Research Site
Amberg, 92224, Germany
Research Site
Bad Bevensen, 29549, Germany
Research Site
Bad Friedrichshall, 47177, Germany
Research Site
Bad Homburg, 61348, Germany
Research Site
Bad Oeynhausen, 32545, Germany
Research Site
Bechhofen, 66894, Germany
Research Site
Berlin, 10117, Germany
Research Site
Berlin, 10559, Germany
Research Site
Berlin, 10629, Germany
Research Site
Berlin, 10787, Germany
Research Site
Berlin, 12203, Germany
Research Site
Berlin, 12559, Germany
Research Site
Berlin, 12627, Germany
Research Site
Berlin, 13347, Germany
Research Site
Berlin, 13353, Germany
Research Site
Bielefeld, 33604, Germany
Research Site
Bonn, 53127, Germany
Research Site
Brandenburg an der Havel, 14776, Germany
Research Site
Bremen, 28277, Germany
Research Site
Bruchsal, 76646, Germany
Research Site
Chemnitz, 9113, Germany
Research Site
Coburg, 96450, Germany
Research Site
Detmold, 32756, Germany
Research Site
Dresden, 01069, Germany
Research Site
Dresden, 01099, Germany
Research Site
Dresden, 01307, Germany
Research Site
Duisburg, 47269, Germany
Research Site
Düsseldorf, 40225, Germany
Research Site
Erlangen, 91054, Germany
Research Site
Essen, 45355, Germany
Research Site
Essen, 45359, Germany
Research Site
Frankfurt, 60389, Germany
Research Site
Frankfurt, 60590, Germany
Research Site
Frankfurt, 60590, Germany
Research Site
Frankfurt, 60596, Germany
Research Site
Frankfurt, 60596, Germany
Research Site
Freiburg im Breisgau, 79106, Germany
Research Site
Fulda, 36037, Germany
Research Site
Gelnhausen, 63571, Germany
Research Site
Gladbeck, 45968, Germany
Research Site
Göttingen, 37075, Germany
Research Site
Greifswald, 17475, Germany
Research Site
Hamburg, 20095, Germany
Research Site
Hamburg, 20099, Germany
Research Site
Hamburg, 20246, Germany
Research Site
Hamburg, 20253, Germany
Research Site
Hamburg, 22041, Germany
Research Site
Hamburg, 22607, Germany
Research Site
Hanover, 30159, Germany
Research Site
Hanover, 30623, Germany
Research Site
Hanover, 30625, Germany
Research Site
Haßloch, 67454, Germany
Research Site
Heidelberg, 69120, Germany
Research Site
Heilbronn, 74076, Germany
Research Site
Herne, 44625, Germany
Research Site
Hohenmölsen, 06679, Germany
Research Site
Jena, 07747, Germany
Research Site
Jerichow, 39319, Germany
Research Site
Kaiserslautern, 67655, Germany
Research Site
Kaiserslautern, 67657, Germany
Research Site
Kamp-Lintfort, 47475, Germany
Research Site
Karlsbad, 76307, Germany
Research Site
Karlsruhe, 76137, Germany
Research Site
Kiel, 24105, Germany
Research Site
Leipzig, 04103, Germany
Research Site
Leipzig, 04103, Germany
Research Site
Leipzig, 04177, Germany
Research Site
Lichtenberg, 10365, Germany
Research Site
Ludwigshafen, 67063, Germany
Research Site
Lübeck, 23538, Germany
Research Site
Lübeck, 23560, Germany
Research Site
Magdeburg, 39120, Germany
Research Site
Mainz, 55122, Germany
Research Site
Mainz, 55131, Germany
Research Site
Mainz A. Rhein, 55131, Germany
Research Site
Mannheim, 68165, Germany
Research Site
Mannheim, 68167, Germany
Research Site
Marburg, 35043, Germany
Research Site
Markkleeberg, 04416, Germany
Research Site
Munich, 80809, Germany
Research Site
Mühldorf A. Inn, 84453, Germany
Research Site
München, 80636, Germany
Research Site
Münster, 48145, Germany
Research Site
Münster, 48149, Germany
Research Site
Nuremberg, 90402, Germany
Research Site
Obertshausen, 63179, Germany
Research Site
Offenbach, 63065, Germany
Research Site
Oranienburg, 16515, Germany
Research Site
Osnabrück, 49080, Germany
Research Site
Papenburg, 26871, Germany
Research Site
Potsdam, 14471, Germany
Research Site
Potsdam, 14473, Germany
Research Site
Ratingen, 40882, Germany
Research Site
Regensburg, 93053, Germany
Research Site
Rostock, 18057, Germany
Research Site
Rostock, 18059, Germany
Research Site
Rotenburg A.d. Fulda, 36199, Germany
Research Site
Rüdersdorf B. Berlin, 15562, Germany
Research Site
Rüsselsheim am Main, 65428, Germany
Research Site
Sankt Ingbert, 66386, Germany
Research Site
Schwerin, 19055, Germany
Research Site
Speyer, 67346, Germany
Research Site
Speyer, 67346, Germany
Research Site
Stuhr, 28816, Germany
Research Site
Stuttgart, 70174, Germany
Research Site
Stuttgart, 70376, Germany
Research Site
Trier, 54292, Germany
Research Site
Tübingen, 72076, Germany
Research Site
Villingen-Schwenningen, 78052, Germany
Research Site
Weinheim, 69469, Germany
Research Site
Wermsdorf, 04779, Germany
Research Site
Wiesbaden, 65189, Germany
Research Site
Witten, 58455, Germany
Research Site
Alexandroupoli, 68100, Greece
Research Site
Athens, 11521, Greece
Research Site
Athens, 11521, Greece
Research Site
Athens, 11527, Greece
Research Site
Athens, 11528, Greece
Research Site
Athens, 12462, Greece
Research Site
Athens, 15123, Greece
Research Site
Athens, 18536, Greece
Research Site
Chios, 82100, Greece
Research Site
Heraklion, 71500, Greece
Research Site
Heraklio, 71110, Greece
Research Site
Ioannina, 45110, Greece
Research Site
Larissa, 41110, Greece
Research Site
Mytilene, 81132, Greece
Research Site
Thessaloniki, 54629, Greece
Research Site
Thessaloniki, 54636, Greece
Research Site
Thessaloniki, 54636, Greece
Research Site
Balatonfüred, 8230, Hungary
Research Site
Békéscsaba, 5600, Hungary
Research Site
Budapest, 1027, Hungary
Research Site
Budapest, 1033, Hungary
Research Site
Budapest, 1036, Hungary
Research Site
Budapest, 1066, Hungary
Research Site
Budapest, 1106, Hungary
Research Site
Budapest, 1122, Hungary
Research Site
Budapest, 1132, Hungary
Research Site
Budapest, 1141, Hungary
Research Site
Budapest, 1148, Hungary
Research Site
Debrecen, 4032, Hungary
Research Site
Encs, 3860, Hungary
Research Site
Kalocsa, 6300, Hungary
Research Site
Kaposvár, 7400, Hungary
Research Site
Nyíregyháza, 4400, Hungary
Research Site
Nyíregyháza-Sóstóhegy, 4481, Hungary
Research Site
Pécs, 7623, Hungary
Research Site
Pécs, 7624, Hungary
Research Site
Szeged, 6725, Hungary
Research Site
Szekszárd, 7100, Hungary
Research Site
Székesfehérvár, 8000, Hungary
Research Site
Szolnok, 5000, Hungary
Research Site
Veszprém, 8200, Hungary
Research Site
Zalaegerszeg, 8900, Hungary
Research Site
Ahmedabad, 380060, India
Research Site
Bangalore, 560069, India
Research Site
Belagavi, 590010, India
Research Site
Dehradun, 248001, India
Research Site
Delhi, 110025, India
Research Site
Delhi, 110029, India
Research Site
Delhi, 110062, India
Research Site
Dwārka, 110075, India
Research Site
Gurgaon, 122001, India
Research Site
Hydarabad, 500055, India
Research Site
Hyderabad, 500034, India
Research Site
Kanpur, 208001, India
Research Site
Kochi, 682018, India
Research Site
Kochi, 682040, India
Research Site
Kolkata, 700099, India
Research Site
Ludhiana, 141001, India
Research Site
Manipal, 576104, India
Research Site
Mumbai, 400008, India
Research Site
Nagpur, 440012, India
Research Site
New Dehli, 110001, India
Research Site
New Delhi, 110002, India
Research Site
New Delhi, 110017, India
Research Site
Vadodara, 390022, India
Research Site
Vijayawada, 520 008, India
Research Site
Altamura, 70022, Italy
Research Site
Arzignano, 36071, Italy
Research Site
Bergamo, 24127, Italy
Research Site
Bologna, 40138, Italy
Research Site
Brescia, 25123, Italy
Research Site
Caserta, 81100, Italy
Research Site
Catania, 95123, Italy
Research Site
Cona, 44124, Italy
Research Site
Florence, 50134, Italy
Research Site
Foggia, 71100, Italy
Research Site
Genoa, 16132, Italy
Research Site
Lecco, 23900, Italy
Research Site
Mestre, 30174, Italy
Research Site
Milan, 20133, Italy
Research Site
Milan, 20162, Italy
Research Site
Naples, 80131, Italy
Research Site
Novara, 28100, Italy
Research Site
Parma, 43126, Italy
Research Site
Pavia, 27100, Italy
Research Site
Perugia, 06129, Italy
Research Site
Pordenone, 33170, Italy
Research Site
Rimini, 47900, Italy
Research Site
Rivoli, 10098, Italy
Research Site
Roma, 00128, Italy
Research Site
Roma, 00133, Italy
Research Site
Roma, 00161, Italy
Research Site
Roma, 00168, Italy
Research Site
Roma, 00184, Italy
Research Site
Rozzano, 20089, Italy
Research Site
Salerno, 84131, Italy
Research Site
Sassari, 07100, Italy
Research Site
Torino, 10126, Italy
Research Site
Torino, 10128, Italy
Research Site
Ami-machi, 300-1155, Japan
Research Site
Asahi-shi, 289-2511, Japan
Research Site
Asahikawa-shi, 070-8530, Japan
Research Site
Chūōku, 103-0002, Japan
Research Site
Chūōku, 103-0027, Japan
Research Site
Fujisawa-shi, 251-0041, Japan
Research Site
Fujisawa-shi, 251-8550, Japan
Research Site
Fukui-shi, 910-8526, Japan
Research Site
Gifu, 500-8717, Japan
Research Site
Hamada-shi, 697-8511, Japan
Research Site
Hamamatsu, 432-8580, Japan
Research Site
Higashiyamato-shi, 207-0014, Japan
Research Site
Hiroshima, 730-8518, Japan
Research Site
Hiroshima, 734-8530, Japan
Research Site
Ichikawa-shi, 272-8516, Japan
Research Site
Itabashi-ku, 173-8610, Japan
Research Site
Izunokuni-shi, 410-2295, Japan
Research Site
Kagoshima, 892-0822, Japan
Research Site
Kagoshima, 892-0853, Japan
Research Site
Kakegawa-shi, 436-8555, Japan
Research Site
Kamakura, 247-8533, Japan
Research Site
Kanazawa, 920-8530, Japan
Research Site
Kanazawa, 920-8650, Japan
Research Site
Kanoya-shi, 893-0015, Japan
Research Site
Kashihara-shi, 634-8522, Japan
Research Site
Kashiwara-shi, 582-0005, Japan
Research Site
Kasuga-shi, 816-0864, Japan
Research Site
Kasuya-gun, 811-2310, Japan
Research Site
Kawasaki-shi, 215-0026, Japan
Research Site
Kishiwada-shi, 596-0042, Japan
Research Site
Kitakyushu, 802-8555, Japan
Research Site
Kobe, 650-0017, Japan
Research Site
Kobe, 654-0026, Japan
Research Site
Kobe, 654-0155, Japan
Research Site
Koga-shi, 811-3195, Japan
Research Site
Komatsu-shi, 923-8560, Japan
Research Site
Kumagaya-shi, 360-0197, Japan
Research Site
Kumamoto, 860-8556, Japan
Research Site
Kure-shi, 737-0023, Japan
Research Site
Kyoto, 604-8845, Japan
Research Site
Kyoto, 605-0981, Japan
Research Site
Kyoto, 607-8062, Japan
Research Site
Machida-shi, 194-0023, Japan
Research Site
Matsuyama, 790-0024, Japan
Research Site
Minatoku, 108-0014, Japan
Research Site
Minatoku, 108-0073, Japan
Research Site
Minokamo Shi, 505-8510, Japan
Research Site
Miyakonojo-shi, 885-0035, Japan
Research Site
Miyazaki, 880-2102, Japan
Research Site
Nagasaki, 850-8555, Japan
Research Site
Nagoya, 454-8502, Japan
Research Site
Naka, 311-0113, Japan
Research Site
Nakagami-gun, 901-2393, Japan
Research Site
Nerima-ku, 176-8530, Japan
Research Site
Niigata, 951-8520, Japan
Research Site
Okayama, 700-0804, Japan
Research Site
Okayama, 701-1192, Japan
Research Site
Okayama, 702-8055, Japan
Research Site
Omura-shi, 856-0021, Japan
Research Site
Omura-shi, 856-8562, Japan
Research Site
Osaka, 530-8480, Japan
Research Site
Osaka, 534-0021, Japan
Research Site
Osaka, 540-0006, Japan
Research Site
Osaka, 543-8922, Japan
Research Site
Osaka, 553-0003, Japan
Research Site
Osaka, 558-8558, Japan
Research Site
Osaka, 559-0012, Japan
Research Site
Ōbu, 474-8511, Japan
Research Site
Ōita, 870-0263, Japan
Research Site
Sapporo, 062-0921, Japan
Research Site
Shinjuku-ku, 160-0004, Japan
Research Site
Shizuoka, 420-8630, Japan
Research Site
Suita-shi, 564-8565, Japan
Research Site
Suwa-shi, 392-8510, Japan
Research Site
Suzuka-shi, 513-8630, Japan
Research Site
Takatsuki-shi, 569-8686, Japan
Research Site
Tamanashi, 865-0016, Japan
Research Site
Tanabe-shi, 646-8558, Japan
Research Site
Tokushima, 770-8539, Japan
Research Site
Toride-shi, 302-0022, Japan
Research Site
Toyama, 930-0194, Japan
Research Site
Toyota, 470-0396, Japan
Research Site
Tsu, 514-1101, Japan
Research Site
Tsukuba, 305-8558, Japan
Research Site
Urasoe-Shi, 901-2102, Japan
Research Site
Urayasu-shi, 279-0021, Japan
Research Site
Ushiku-shi, 300-1207, Japan
Research Site
Utsunomiya, 320-8580, Japan
Research Site
Wako-shi, 351-0102, Japan
Research Site
Yokohama, 222-0036, Japan
Research Site
Yokohama, 245-8575, Japan
Research Site
Alor Star, 5460, Malaysia
Research Site
Cheras, 56000, Malaysia
Research Site
George Town, 10050, Malaysia
Research Site
Kajang, 43000, Malaysia
Research Site
Kota Kinabalu, 88300, Malaysia
Research Site
Kota Samarahan, 94300, Malaysia
Research Site
Kuala Lumpur, 50400, Malaysia
Research Site
Kuala Lumpur, 59100, Malaysia
Research Site
Kuala Terengganu, 20400, Malaysia
Research Site
Kuantan, 25100, Malaysia
Research Site
Kubang Kerian, 16150, Malaysia
Research Site
Kuching, 93586, Malaysia
Research Site
Sarawak Miri, 98000, Malaysia
Research Site
Seri Manjung, 32040, Malaysia
Research Site
Acapulco, 39670, Mexico
Research Site
Aguascalientes, 20230, Mexico
Research Site
Chihuahua City, 31000, Mexico
Research Site
Cuauhtémoc, 6720, Mexico
Research Site
Cuernavaca, 62250, Mexico
Research Site
Cuernavaca, 62448, Mexico
Research Site
Culiacán, 80230, Mexico
Research Site
Guadalajara, 44670, Mexico
Research Site
Mexico City, 06700, Mexico
Research Site
Mexico City, 07300, Mexico
Research Site
Mexico City, 10700, Mexico
Research Site
México, 03300, Mexico
Research Site
México, 07020, Mexico
Research Site
México, 14080, Mexico
Research Site
Monterrey, 64020, Mexico
Research Site
Monterrey, 64060, Mexico
Research Site
Querétaro, 76000, Mexico
Research Site
San Juan del Río, 76800, Mexico
Research Site
Torreón, 27000, Mexico
Research Site
Veracruz, 91910, Mexico
Research Site
Zapopan, 45138, Mexico
Research Site
Auckland, 0626, New Zealand
Research Site
Christchurch, 8011, New Zealand
Research Site
Ebdentown, 5018, New Zealand
Research Site
Grafton, 1010, New Zealand
Research Site
Hamilton, 3200, New Zealand
Research Site
Hastings, 4122, New Zealand
Research Site
Hutt Central, 5010, New Zealand
Research Site
New Lynn, 0600, New Zealand
Research Site
Palmerston North Central, 4414, New Zealand
Research Site
Papatoetoe, 2025, New Zealand
Research Site
Pukekohe, 2120, New Zealand
Research Site
Rotorua, 3010, New Zealand
Research Site
Woodhill, 0110, New Zealand
Research Site
Bellavista, CALLAO 2, Peru
Research Site
Chorrillos, Lima 9, Peru
Research Site
Lima, 15036, Peru
Research Site
Lima, 15038, Peru
Research Site
Lima, 15046, Peru
Research Site
Lima, 15046, Peru
Research Site
Lima, 15072, Peru
Research Site
Lima, 15073, Peru
Research Site
Lima, 15088, Peru
Research Site
Lima, 15102, Peru
Research Site
Lima, 15131, Peru
Research Site
Lima, Lima 10, Peru
Research Site
Lima, LIMA 1, Peru
Research Site
Lima, LIMA 41, Peru
Research Site
Miraflores, 15046, Peru
Research Site
Piura, 20001, Peru
Research Site
San Isidro, 27, Peru
Research Site
Wanchac, 8002, Peru
Research Site
Angeles City, 2009, Philippines
Research Site
Baguio City, 2600, Philippines
Research Site
Cebu, 6000, Philippines
Research Site
Cebu, 6000, Philippines
Research Site
Dasmariñas, 4114, Philippines
Research Site
Davao City, 8000, Philippines
Research Site
Davao City, PH-8000, Philippines
Research Site
Iloilo City, 5000, Philippines
Research Site
Laguna, 4024, Philippines
Research Site
Manadaluyong City, 1552, Philippines
Research Site
Manila, 1000, Philippines
Research Site
Marikina City, 1800, Philippines
Research Site
Pasig, 1605, Philippines
Research Site
Quezon City, 1000, Philippines
Research Site
Quezon City, 1100, Philippines
Research Site
Quezon City, 1112, Philippines
Research Site
San Juan City, 1502, Philippines
Research Site
Tacloban City, 6500, Philippines
Research Site
Bialystok, 15-481, Poland
Research Site
Bydgoszcz, 85-065, Poland
Research Site
Gdansk, 80-214, Poland
Research Site
Gdynia, 81-157, Poland
Research Site
Gdynia, 81-384, Poland
Research Site
Gdynia, 81-537, Poland
Research Site
Jelenia Góra, 58-506, Poland
Research Site
Katowice, 40-600, Poland
Research Site
Kędzierzyn-Koźle, 47-200, Poland
Research Site
Krakow, 31-121, Poland
Research Site
Krakow, 31-322, Poland
Research Site
Krakow, 31-501, Poland
Research Site
Lodz, 90-127, Poland
Research Site
Lodz, 91-363, Poland
Research Site
Lodz, 93-338, Poland
Research Site
Lodz, 93-513, Poland
Research Site
Lublin, 20-011, Poland
Research Site
Lublin, 20-068, Poland
Research Site
Lublin, 20-718, Poland
Research Site
Lublin, 20-718, Poland
Research Site
Ostrów Mazowiecka, 07-300, Poland
Research Site
Poznan, 61-848, Poland
Research Site
Płock, 09-407, Poland
Research Site
Ruda Śląska, 41-710, Poland
Research Site
Rzeszów, 35-205, Poland
Research Site
Szczecin, 71-526, Poland
Research Site
Tarnów, 33-100, Poland
Research Site
Torun, 87-100, Poland
Research Site
Torun, 87-100, Poland
Research Site
Warsaw, 00-124, Poland
Research Site
Warsaw, 02-758, Poland
Research Site
Warsaw, 04-628, Poland
Research Site
Warsaw, 04-628, Poland
Research Site
Wroclaw, 53-673, Poland
Research Site
Mayagüez, 00682, Puerto Rico
Research Site
San Juan, 00918, Puerto Rico
Research Site
San Juan, 00921-3201, Puerto Rico
Research Site
Arad, 310037, Romania
Research Site
Bacau, 600274, Romania
Research Site
Bucharest, 012071, Romania
Research Site
Bucharest, 014142, Romania
Research Site
Bucharest, 032258, Romania
Research Site
Bucharest, 041914, Romania
Research Site
Bucharest, 050098, Romania
Research Site
Craiova, 200642, Romania
Research Site
Iași, 700023, Romania
Research Site
Oradea, 410032, Romania
Research Site
Oradea, 410167, Romania
Research Site
Satu Mare, 440055, Romania
Research Site
Târgu Mureş, 540099, Romania
Research Site
Târgu Mureş, 540136, Romania
Research Site
Timișoara, 300079, Romania
Research Site
Bratislava, 831 01, Slovakia
Research Site
Bratislava, 83101, Slovakia
Research Site
Bratislava, 83106, Slovakia
Research Site
Bratislava, 83348, Slovakia
Research Site
Bratislava, 85101, Slovakia
Research Site
Brezno, 977 01, Slovakia
Research Site
Dolný Kubín, 026 01, Slovakia
Research Site
Košice, 040 01, Slovakia
Research Site
Košice, 04011, Slovakia
Research Site
Košice, 04022, Slovakia
Research Site
Levice, 934 01, Slovakia
Research Site
Levice, 93401, Slovakia
Research Site
Malacky, 901 22, Slovakia
Research Site
Malacky, 90101, Slovakia
Research Site
Nitra, 949 01, Slovakia
Research Site
Nitra, 949 11, Slovakia
Research Site
Poprad, 05845, Slovakia
Research Site
Prešov, 080 01, Slovakia
Research Site
Prešov, 080 01, Slovakia
Research Site
Šamorín, 931 01, Slovakia
Research Site
Trnava, 91702, Slovakia
Research Site
Vinica, 991 28, Slovakia
Research Site
Žilina, 010 01, Slovakia
Research Site
Bellville, 7530, South Africa
Research Site
Benoni, 1501, South Africa
Research Site
Bloemfontein, 9301, South Africa
Research Site
Brackenfell, 7560, South Africa
Research Site
Cape Town, 7500, South Africa
Research Site
Cape Town, 7530, South Africa
Research Site
Cape Town, 7570, South Africa
Research Site
Centurion, 0157, South Africa
Research Site
Durban, 4001, South Africa
Research Site
eMkhomazi, 4170, South Africa
Research Site
George, 6529, South Africa
Research Site
Johannesburg, 1827, South Africa
Research Site
Johannesburg, 2157, South Africa
Research Site
Kimberley, 8301, South Africa
Research Site
Middelbrug, 1029, South Africa
Research Site
Midrand, 1685, South Africa
Research Site
Paarl, 7626, South Africa
Research Site
Paarl, 7646, South Africa
Research Site
Panorama, 7500, South Africa
Research Site
Pretoria, 0183, South Africa
Research Site
Somerset West, 7130, South Africa
Research Site
Umhlanga, 4319, South Africa
Research Site
Wentworth, 4032, South Africa
Research Site
Bucheon-si, 14754, South Korea
Research Site
Busan, 49201, South Korea
Research Site
Busan, 49241, South Korea
Research Site
Busan, 49267, South Korea
Research Site
Changwon-si, 51139, South Korea
Research Site
Daegu, 42415, South Korea
Research Site
Daegu, 42601, South Korea
Research Site
Daejeon, 35015, South Korea
Research Site
Goyang-si, 10444, South Korea
Research Site
Goyang-si, 13620, South Korea
Research Site
Gwangju, 61469, South Korea
Research Site
Gwangmyeong, 14353, South Korea
Research Site
Junggu, 41944, South Korea
Research Site
Seoul, 03080, South Korea
Research Site
Seoul, 03181, South Korea
Research Site
Seoul, 05505, South Korea
Research Site
Seoul, 06273, South Korea
Research Site
Seoul, 06351, South Korea
Research Site
Seoul, 06973, South Korea
Research Site
Seoul, 07061, South Korea
Research Site
Seoul, 08308, South Korea
Research Site
Seoul, 120-752, South Korea
Research Site
Seoul, 2841, South Korea
Research Site
Suncheon, 57931, South Korea
Research Site
Yongin-si, 16995, South Korea
Research Site
A Coruña, 15006, Spain
Research Site
A Coruña, 15006, Spain
Research Site
Alicante, 03010, Spain
Research Site
Barcelona, 08003, Spain
Research Site
Barcelona, 08025, Spain
Research Site
Barcelona, 08035, Spain
Research Site
Barcelona, 08036, Spain
Research Site
Barcelona, 08041, Spain
Research Site
Madrid, 28040, Spain
Research Site
Madrid, 28041, Spain
Research Site
Málaga, 29010, Spain
Research Site
Murcia, 30120, Spain
Research Site
Palma de Mallorca, 07198, Spain
Research Site
Sanlúcar de Barrameda (Cádiz), 11540, Spain
Research Site
Santiago(A Coruña), 15706, Spain
Research Site
Seville, 41013, Spain
Research Site
Tarragona, 43007, Spain
Research Site
Valencia, 46010, Spain
Research Site
Vigo, 36312, Spain
Research Site
Villamartín (Cádiz), 11650, Spain
Research Site
Zaragoza, 50009, Spain
Research Site
Alingsås, 44183, Sweden
Research Site
Falun, 791 82, Sweden
Research Site
Huddinge, 141 86, Sweden
Research Site
Lund, 22185, Sweden
Research Site
Östersund, 831 83, Sweden
Research Site
Stockholm, 11630, Sweden
Research Site
Stockholm, 118 83, Sweden
Research Site
Umeå, 90185, Sweden
Research Site
Uppsala, 751 85, Sweden
Research Site
Västerås, 721 89, Sweden
Research Site
Changhua, 500, Taiwan
Research Site
Hsinchu, 300, Taiwan
Research Site
Hualien City, 970, Taiwan
Research Site
Kaohsiung City, 80756, Taiwan
Research Site
Kaohsiung City, 813, Taiwan
Research Site
Kaohsiung City, 824, Taiwan
Research Site
New Taipei City, 220, Taiwan
Research Site
New Taipei City, 231, Taiwan
Research Site
Taichung, 40201, Taiwan
Research Site
Taichung, 40447, Taiwan
Research Site
Taichung, 40705, Taiwan
Research Site
Taichung, 433004, Taiwan
Research Site
Tainan, 710027, Taiwan
Research Site
Taipei, 100, Taiwan
Research Site
Taipei, 10449, Taiwan
Research Site
Taipei, 110, Taiwan
Research Site
Taipei, 11101, Taiwan
Research Site
Taipei, 11217, Taiwan
Research Site
Taipei, 11490, Taiwan
Research Site
Taipei, 116, Taiwan
Research Site
Taoyuan District, 333, Taiwan
Research Site
Yilan, 260, Taiwan
Research Site
Bangkok, 10330, Thailand
Research Site
Bangkok, 10400, Thailand
Research Site
Bangkok, 10700, Thailand
Research Site
Banphaeo, 74120, Thailand
Research Site
Chiang Mai, 50200, Thailand
Research Site
Hat Yai, 90110, Thailand
Research Site
Khon Kaen, 40002, Thailand
Research Site
Klong Luang, 12120, Thailand
Research Site
Mueang, 20000, Thailand
Research Site
Nakhon Ratchasima, 30000, Thailand
Research Site
Udon Thani, 41000, Thailand
Research Site
Afyonkarahisar, 03030, Turkey (Türkiye)
Research Site
Ankara, 06530, Turkey (Türkiye)
Research Site
Antalya, 07100, Turkey (Türkiye)
Research Site
Çanakkale, 17110, Turkey (Türkiye)
Research Site
Edirne, 22030, Turkey (Türkiye)
Research Site
Istanbul, 34010, Turkey (Türkiye)
Research Site
Istanbul, 34096, Turkey (Türkiye)
Research Site
Izmir, 35040, Turkey (Türkiye)
Research Site
Kayseri, 38039, Turkey (Türkiye)
Research Site
Kazımkarabekir, 01230, Turkey (Türkiye)
Research Site
Kütahya, 43100, Turkey (Türkiye)
Research Site
Muğla, 48000, Turkey (Türkiye)
Research Site
Odunpazari, 26080, Turkey (Türkiye)
Research Site
Tokat Province, 60030, Turkey (Türkiye)
Research Site
Yenimahalle, 06170, Turkey (Türkiye)
Research Site
Chernivtsi, 58022, Ukraine
Research Site
Ivano-Frankivsk, 76018, Ukraine
Research Site
Kyiv, 02081, Ukraine
Research Site
Kyiv, 02166, Ukraine
Research Site
Kyiv, 03037, Ukraine
Research Site
Kyiv, 03049, Ukraine
Research Site
Kyiv, 03151, Ukraine
Research Site
Kyiv, 03680, Ukraine
Research Site
Kyiv, 04050, Ukraine
Research Site
Kyiv, 04114, Ukraine
Research Site
Lutsk, 430024, Ukraine
Research Site
Uzhhorod, 88014, Ukraine
Research Site
Uzhhorod, 88014, Ukraine
Research Site
Vinnytsia, 21001, Ukraine
Research Site
Vinnytsia, 21009, Ukraine
Research Site
Vinnytsia, 21029, Ukraine
Research Site
Zhytomyr, 100002, Ukraine
Research Site
Birmingham, B18 7QH, United Kingdom
Research Site
Birmingham, B21 9RY, United Kingdom
Research Site
Bournemouth, BH7 7DW, United Kingdom
Research Site
Bridgend, CF31 1RQ, United Kingdom
Research Site
Bristol, BS105NB, United Kingdom
Research Site
Calow, S44 5BL, United Kingdom
Research Site
Cambridge, CB2 0QQ, United Kingdom
Research Site
Chippenham, SN15 2SB, United Kingdom
Research Site
Congleton, CW12 1JP, United Kingdom
Research Site
Dudley, DY1 2HQ, United Kingdom
Research Site
Dundee, DD1 9SY, United Kingdom
Research Site
Enfield, EN1 3LL, United Kingdom
Research Site
Gateshead, NE9 6SX, United Kingdom
Research Site
Glasgow, G20 7BE, United Kingdom
Research Site
Harefield, UB9 6JH, United Kingdom
Research Site
Isleworth, TW7 6AF, United Kingdom
Research Site
Kings Lynn, PE30 4ET, United Kingdom
Research Site
Lincoln, LN2 5QY, United Kingdom
Research Site
London, EC1M 6BQ, United Kingdom
Research Site
London, N20 9EX, United Kingdom
Research Site
London, NW3 2QG, United Kingdom
Research Site
Metropolitan Borough of Wirral, CH62 6EE, United Kingdom
Research Site
Middlesbrough, TS4 3BW, United Kingdom
Research Site
Middlesex, HA5 4EA, United Kingdom
Research Site
Milton Keynes, MK6 5LD, United Kingdom
Research Site
Newcastle upon Tyne, NE1 4LP, United Kingdom
Research Site
Poole, BH16 5PW, United Kingdom
Research Site
Portsmouth, PO6 3LY, United Kingdom
Research Site
Sheffield, S5 7AU, United Kingdom
Research Site
Southampton, SO16 6YD, United Kingdom
Research Site
Taunton, TA1 5DA, United Kingdom
Research Site
Wakefield, WF1 4DG, United Kingdom
Research Site
Worcester, WR5 1DD, United Kingdom
Research Site
Wrexham, LL13 7TD, United Kingdom
Research Site
Yeovil, BA21 4AT, United Kingdom
Research Site
Can Tho, 900000, Vietnam
Research Site
Da Nang, 550000, Vietnam
Research Site
Haiphong, 180000, Vietnam
Research Site
Hanoi, 100000, Vietnam
Research Site
Hanoi, 10000, Vietnam
Research Site
Ho Chi Minh City, 700000, Vietnam
Research Site
Ho Chi Minh City, 700000, Vietnam
Research Site
Ho Chi Minh City, 700000, Vietnam
Research Site
Ho Chi Minh City, 700000, Vietnam
Research Site
Ho Chi Minh City, 70000, Vietnam
Research Site
Hochiminh, 70000, Vietnam
Research Site
Hồ Chí Minh, 9000, Vietnam
Research Site
Huế, 530000, Vietnam
Research Site
Huế, 530000, Vietnam
Research Site
Vĩnh Yên, 280000, Vietnam
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
AstraZeneca Clinical Study Information Center
CONTACT
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Placebo controlled
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 30, 2025
First Posted
June 2, 2025
Study Start
June 4, 2025
Primary Completion (Estimated)
October 26, 2029
Study Completion (Estimated)
October 26, 2029
Last Updated
April 17, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA/PhRMA Data-Sharing Principles. For details of our timelines, please refer to our disclosure commitment at: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
- Access Criteria
- When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. A Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information.
Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.