Improving Diagnosis of Legume Allergy in Children

NCT06995950 | Not Yet Recruiting

• 1 other identifier: 2024PI140
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

In France, almost 15% of serious food allergies in children are caused by legumes, especially peanuts. Other legumes like soy, lentils, peas, lupin, chickpeas, beans, and fenugreek can also cause allergic reactions. But here's the problem: only peanuts, soy, and lupin are required to be clearly labeled on food packaging in the European Union. This makes it hard for families to know when other legumes-like peas or fenugreek-are hidden in processed foods. Avoiding all these legumes is hard-especially since many of them are used in processed foods and not always listed on the label. Right now, detailed allergy tests to evaluate the probability of allergy diagnosis are only available for peanuts and soy, and not for other legumes. LACID study has been created to find and study the proteins in lupin, fenugreek, and peas that may cause allergies and developp better allergy tests for these legumes-possibly as part of a diagnostic tool that can give clear results using just a blood sample. The goal is to help doctors and families better understand which legumes a child really needs to avoid-and which ones are actually safe to eat.

Conditions

Food Allergy in Children; Legumes Allergy; Molecular Diagnostic

Keywords

food allergy; legume; children; molecular allergology

Outcome Measures

Primary Outcomes (1)

• Legume allergy

  Number of children with a confirmed allergy to pea, fenugreek or lupin (an allergic reaction in real life or a positive oral food challenge)

  in the past 2 years before recruitment and until the end of recruitment

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children sensitised to lupine, fenugreek or pea, treated in French Allergy Pediatric units, with data regarding tolerance of at least one these three legumes

You may qualify if:

• Sensitised to lupine, fenugreek or pea

You may not qualify if:

• on going anti-IgE treatment or in the last 6 months

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead
• University Hospital, Lille: collaborator

MeSH Terms

Conditions

Food Hypersensitivity

Condition Hierarchy (Ancestors)

Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Amandine Divaret-Chauveau, MD, PhD

  Pediatric Allergy Unit, University Hospital of Nancy

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amandine Divaret-Chauveau, MD, PhD

CONTACT

+33 6 30 09 46 06; a.chauveau@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: May 30, 2025
• Study Start: June 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: June 5, 2025

Record last verified: 2025-06