Lupine Allergy in Children

NCT06918249 | Completed

• 1 other identifier: 2025LAIC
• Study Type: observational
• Target: 39
• Locations: 0 countries
• Sites: N/A

Brief Summary

All children sensitized to lupine who have performed an oral food challenge (OFC) to lupine between January 2017 and May 2024 in the Pediatric Allergy Unit of the University Hospital of Nancy were included. Retrospective data regarding food and respiratory allergies were collected as well as information regarding lupine skin prick test (SPT), specific IgE (sIgE) and OFC. Severity of allergic reaction was evaluated by CoFAR grade and reactogenic cumulative threshold dose. Aims of this study were (i) to assess relevance of sensitization to lupine in children and (ii) to describe severity of reactions in case of allergy.

Conditions

Food Allergy in Children

Outcome Measures

Primary Outcomes (1)

• diagnostic value of prick test and specific IgE

  prick test to lupine flour in mm done during interview and collected retrospectively Specific IgE in kU/L to lupine seed done during same interview and collected retrospectively prick test and sIgE done as in usual clinical practice main outcome of the study are statistical tests (ROC curve) done to analyse diagnostic values of prick test and sIgE in this population

  baseline

Secondary Outcomes (1)

• severity of allergic reaction in oral food challenge

  baseline

Interventions

No intervention OTHER

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

children under 18 years as the study was done in the Pediatric Allergy department

You may qualify if:

• cutaneous or biological sensitization to lupine

You may not qualify if:

• oral food challenge done with something other than lupine flour

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: March 30, 2025
• First Posted: April 9, 2025
• Study Start: January 1, 2017
• Primary Completion: May 1, 2024
• Study Completion: May 1, 2024
• Last Updated: April 9, 2025

Record last verified: 2025-04