Blood Flow Restriction for Ulnar Sided Wrist Pain

NCT06963671 | Enrolling By Invitation

• 1 other identifier: 80801
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the strength, pain and functional benefits of early, low-load resistance training with blood flow restriction (BFR) in ulnar-sided wrist pain treated nonoperatively with immobilization for 4-6 weeks. Hypothesis: patients in the BFR group with have improved grip strength and patient reported outcome measure scores compared to the control group.

Conditions

Ulnar Wrist Pain

Keywords

blood flow restriction

Outcome Measures

Primary Outcomes (1)

• Grip Strength

  Grip Strength as measured by a dynamometer in pounds.

  From enrollment to 6 weeks after initiation of BRF

Secondary Outcomes (1)

• Patient Reported Wrist Evaluation (PRWE)

  From enrollment to 6 weeks after initiation of BRF

Study Arms (2)

Control

NO INTERVENTION

The control arm will receive the standard of care treatment for ulnar sided wrist pain

Blood Flow Restriction

EXPERIMENTAL

The Blood Flow Restriction group will receive BFR treatment

Behavioral: Blood Flow Restriction

Interventions

Blood Flow Restriction BEHAVIORAL

The treatment group will receive standard rehabilitation as a home program plus low-load resistance training with BFR application while at the hand therapy clinic for their appointments

Blood Flow Restriction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients (\>18 years) undergoing outpatient rehabilitation at Stanford Hand Therapy
• English fluency and literacy
• Able to take informed consent
• Have acute or chronic ulnar-sided wrist pain referred for a course of hand therapy by a physician or advanced practice provider (APP) and were treated with continuous immobilization for 4-6 weeks.
• Score of 3 or less on blood flow restriction screening questionnaire

You may not qualify if:

• Concomitant injuries such as upper extremity fractures or other ligamentous injuries
• TFCC surgery in the affected wrist
• Non-compliance with immobilization
• Patients who complete hand therapy at an outside facility
• Score of 4 or more on blood flow restriction screening questionnaire

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford University

Redwood City, California, 94063, United States

Location

MeSH Terms

Interventions

Blood Flow Restriction Therapy

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 30, 2025
• First Posted: May 9, 2025
• Study Start: August 11, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: October 3, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)