NCT06961877

Brief Summary

The objectives of this research is to (1) create a family intervention and provider manual to train family members of young people with psychosis (YP-P) who are heavy cannabis users new communication skills to motivate change in the YP-P's cannabis use, (2) pre-test the intervention with 10 family member participants and adapt the intervention based on their recommendations, and (3) evaluate the feasibility and acceptability of the intervention in a randomized pilot trial (n=40). The investigators anticipate that the intervention will improve family participants' communication skills, decrease expressed emotion and caregiver burden. The investigators anticipate that improvements in communication skills, expressed emotion and caregiver burden will lead to decreases in the cannabis use of their YP-P.

Trial Health

63
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
14mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress31%
Oct 2025Jul 2027

First Submitted

Initial submission to the registry

April 24, 2025

Completed
14 days until next milestone

First Posted

Study publicly available on registry

May 8, 2025

Completed
6 months until next milestone

Study Start

First participant enrolled

October 31, 2025

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2027

Last Updated

September 11, 2025

Status Verified

September 1, 2025

Enrollment Period

1.3 years

First QC Date

April 24, 2025

Last Update Submit

September 4, 2025

Conditions

Keywords

coordinated specialty carecannabis use disorderfirst episode psychosiscaregiver burdencannabis usecommunication skills

Outcome Measures

Primary Outcomes (5)

  • Cannabis and psychosis knowledge

    Cannabis knowledge test. This measure does not use a scale; multiple choice items test understanding of cannabis products, consumption, and impacts. Higher scores indicate higher level of cannabis knowledge.

    baseline, 3 month follow-up

  • Caregiver Burden Index

    The CBI is a 24-item assessment of both objective (time away from work for caregiving) and subjective (psychological impact) burden of caregiving in a Likert-format scale (0-4) that measures five dimensions of caregiver burden: time dependence, developmental, physical, social, and emotional burden. Each sub scale ranges from 0 (low ) to 20 (high).

    baseline, 3 month follow-up

  • Family Attitudes Scale (FAS)

    The FAS is a 30-item self-report measure of expressed emotion (EE) using a Likert scale (e.g., 1 to 5); higher scores indicate more positive attitudes towards family dynamics, while lower scores suggests negative attitudes.

    baseline, 3 month follow-up

  • Timeline Followback - Collateral version (TLFB-C)

    The TLFB will ask participants to complete a calendar for the past 30 days indicating the days they believe their YA-P used cannabis and other substances.

    baseline, 3 month follow up

  • Motivational Interviewing Treatment Integrity (MITI)

    Participants will complete an audio-recorded encounter with a standardized patient who will remain in character as a YA-P who uses cannabis.

    baseline, post-treatment (6 week)

Secondary Outcomes (1)

  • Client Satisfaction Questionnaire (CSQ-8)

    3 month follow up

Study Arms (2)

Cannabis Conversation Skills for Families (CCSF)

EXPERIMENTAL

The purpose of the intervention is to train family members in communication skills that may increase contemplation of change in their loved one with first episode psychosis to reduce cannabis use, decrease conflict surrounding these discussions, and provide skills to understand when and how to approach their loved one about cannabis use and encourage treatment. Six sessions (90 minutes each) will be held weekly in a closed group format via Zoom, with the same therapist leading each group. Group size will be 3-8 participants, with an average wait time of 4 weeks. Assessments will occur at baseline, post-treatment, and at a 3-month follow-up.

Behavioral: Cannabis Conversation Skills for Families (CCSF)

Treatment as Usual (TAU) Control

NO INTERVENTION

In this project, treatment as usual will consist of psychoeducation on cannabis and its impacts on psychosis and family services otherwise provided to participants through their participation in the coordinated specialty care program at which their loved one is enrolled. The investigators will track what each family receives and characterize the content and dose in analysis.

Interventions

The purpose of the intervention is to train family members in communication skills that may increase contemplation of change in their loved one with first episode psychosis to reduce cannabis use, decrease conflict surrounding these discussions, and provide skills to understand when and how to approach their loved one about cannabis use and encourage treatment. Because families report confusion from the mixed messages they receive about cannabis and also desire research-based information, CCSF will involve psychoeducation on the risks and relationship of cannabis to psychosis to increase participants motivation to engage in the intervention. frequency of cannabis use as it relates to psychosis treatment outcomes.

Cannabis Conversation Skills for Families (CCSF)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • aged 18 years or older,
  • has a loved one who is both in CSC treatment for FEP and has used cannabis in the past 30 days,
  • has regular contact with their loved one with FEP. It is assumed that YA-P will be aged 13-40 with schizophrenia spectrum disorder given criteria for CSC enrollment.

You may not qualify if:

  • Unable to read study materials and communicate feedback in English
  • Do not have access to Zoom

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Washington

Seattle, Washington, 98195, United States

Location

MeSH Terms

Conditions

Caregiver Burden

Condition Hierarchy (Ancestors)

Stress, PsychologicalBehavioral SymptomsBehavior

Study Officials

  • Denise Walker, Ph.D.

    Arizona State University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Denise Walker, Ph.D.

CONTACT

Ty Tristao, BA

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Professor

Study Record Dates

First Submitted

April 24, 2025

First Posted

May 8, 2025

Study Start

October 31, 2025

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

July 1, 2027

Last Updated

September 11, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will share

All scientific data (survey response data) will be both preserved and shared. Data will be made publicly available to the research community. This will include but may not be limited to (a) survey items and corresponding response options (including missingness coding), (b) a codebook for scoring survey items and composite scales, (c) a detailed description of internally computed variables (e.g., time spent viewing intervention content), and (d) documentation of intervention components that participants were exposed to (both treatment and control conditions). Public use and restricted access study data and associated documentation will be made available to the research community free of charge through the NIAAA Data Archive.

Shared Documents
STUDY PROTOCOL, ICF, ANALYTIC CODE
Time Frame
Data will be shared with the general research community at the time of an associated publication, or the end of the award/support period, whichever comes first.
Access Criteria
The data will be made available for sharing with the general research community via the NDA website. Investigators at institutions with a Federal Wide Assurance (FWA) will be able to gain access to NDA data by submitting a data access request in accordance with applicable NDA policies.

Locations