Stress and Resilience

NCT06457841 | Recruiting DMC

• 2 other identifiers: STUDY00018058R01DA058626
• Study Type: interventional
• Target: 456
• Locations: 1 country
• Sites: 2

Brief Summary

Alcohol and cannabis are the most misused psychoactive substances in the United States. The proposed research examines how personally relevant stressful experiences may lead to alcohol and cannabis use. The proposed research is also designed to identify possible targets for prevention and treatment efforts to help reduce drug use.

Conditions

Alcohol Use; Cannabis Use

Outcome Measures

Primary Outcomes (2)

• Momentary Alcohol and/or Cannabis Craving

  Momentary Alcohol and Cannabis Craving Scale will be administered (adapted from the Momentary Cannabis Craving Scale; Davis et al., 2024) immediately after the intervention. Mean scores will range from 1 to 7, with higher scores indicating greater momentary craving.

  Immediately after the intervention (i.e., within 1 minute)

• Duration of Alcohol and Cannabis Intoxication

  Self-reported number of hours of intoxication within 48 hours after the intervention

  48 Hours Post-Intervention

Study Arms (3)

Direct Interpersonal Exchange

EXPERIMENTAL

Simulated a negative personally relevant interpersonal experience that is received directly from a perpetrator, commonly experienced in everyday lives

Behavioral: Direct Interpersonal Exchange

Vicarious Interpersonal Exchange

EXPERIMENTAL

Hearing or observing a negative personally relevant interpersonal experience that is reported by another person of the same background

Behavioral: Vicarious Interpersonal Exchange

Daily Hassles

PLACEBO COMPARATOR

Day-to-day stressors associated with school, work, finances

Behavioral: Daily Hassles

Interventions

Direct Interpersonal Exchange BEHAVIORAL

Simulated a negative personally relevant interpersonal experience that is received directly from a perpetrator, commonly experienced in everyday lives

Direct Interpersonal Exchange

Vicarious Interpersonal Exchange BEHAVIORAL

Hearing or observing a negative personally relevant interpersonal experience that is reported by another person of the same background

Vicarious Interpersonal Exchange

Daily Hassles BEHAVIORAL

Day-to-day stressors associated with school, work, finances

Daily Hassles

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Of Afro-descent
• Proficient in English
• Alcohol and/or cannabis use at least 2-3 times in the past month
• Endorse having used alcohol and/or cannabis to cope

You may not qualify if:

• Having participated in similar studies by the research team
• Obtain cut-off scores on scale items indicating possible loss of control and needing to cut down or quit alcohol and/or cannabis use
• In or seeking treatment for alcohol and/or cannabis use disorder

Sponsors & Collaborators

• University of Washington: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (2)

Southern Methodist University

Dallas, Texas, 75204, United States

RECRUITING

University of Washington

Seattle, Washington, 98195, United States

RECRUITING

MeSH Terms

Conditions

Alcohol Drinking

Condition Hierarchy (Ancestors)

Drinking Behavior; Behavior

Study Officials

• P. Priscilla Lui, Ph.D.

  University of Washington

  PRINCIPAL INVESTIGATOR

Central Study Contacts

P. Priscilla Lui, Ph.D.

CONTACT

206-685-8391; pplui@uw.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Department of Psychology

Study Record Dates

• First Submitted: May 28, 2024
• First Posted: June 13, 2024
• Study Start: May 9, 2024
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: July 15, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)