REhabilitation of MEMory Symptoms After BRain Concussion
REMEMBR
1 other identifier
interventional
184
1 country
9
Brief Summary
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective memory functioning. The present study will more definitively compare the effectiveness of these interventions for improving subjective memory functioning after concussion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jul 2025
Longer than P75 for not_applicable
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 25, 2025
CompletedFirst Posted
Study publicly available on registry
May 4, 2025
CompletedStudy Start
First participant enrolled
July 2, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 30, 2029
July 30, 2025
July 1, 2025
2.8 years
April 25, 2025
July 29, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Multifactorial Memory Questionnaire-Satisfaction scale
Measures participants' concern, satisfaction, and overall appraisal of their memory ability. Participants rate their agreement with 18 statements. Total scores range from 0 to 72, with lower total scores indicating worse subjective memory functioning.
Week 20
Secondary Outcomes (3)
Fear-Avoidance of Memory Loss Scale
Week 1 and week 20
Patient Global Impression of Change scale
Week 20
Work and Social Adjustment Scale
Week 1 and week 20
Study Arms (3)
Cognitive behavioral therapy
EXPERIMENTALCognitive rehabilitation
ACTIVE COMPARATORWaitlist - Usual care
NO INTERVENTIONInterventions
Cognitive behavioral therapy (CBT) is delivered by a psychologist over 10 individual (1:1) manualized videoconference sessions. The goal of this therapy is for participants to use their memory more normally (i.e., reduce avoidance and safety behaviors) and view memory lapses as less threatening.
Cognitive compensatory strategy training (CCST), a traditional cognitive rehabilitation intervention, is delivered by a Occupational Therapist over 10 individual (1:1) manualized videoconference sessions. Participants optimize their use of current compensatory strategies and/or learn new ones suited to their needs and lifestyle. The goal is to minimize memory lapses in daily life.
Eligibility Criteria
You may qualify if:
- Age 18-59
- Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria
- Concussion occurred between 6 and 36 months before enrollment
- Ongoing memory concerns
- Fluent in English
- Stable access to a computer, tablet, or smartphone with internet capability
You may not qualify if:
- Fail performance validity testing
- Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (9)
Calgary Brain Injury Program
Calgary, Alberta, T2N 2T9, Canada
Fraser Health Acquired Brain Injury and Concussion Services
Langley, British Columbia, V1M 4A6, Canada
G.F. Strong Adult Concussion Services
Vancouver, British Columbia, V5Z 2G9, Canada
Integrated Adult Concussion Program at Hamilton Health Sciences
Hamilton, Ontario, L8N 3Z5, Canada
360 Concussion Care Clinic
Ottawa, Ontario, K1H 7X7, Canada
Sunnybrook Traumatic Brain Injury Clinic
Toronto, Ontario, M4N 3M5, Canada
Head Injury Clinic at St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
Hull-Ellis Concussion and Research Clinic at University Health Network
Toronto, Ontario, M5G 2A2, Canada
Canadian Concussion Centre at Toronto Western Hospital
Toronto, Ontario, M5T 2S8, Canada
Related Publications (1)
Rioux M, Mamman R, Byworth MT, Panenka WJ, Howard AK, Perez DL, Schmidt J, Courchesne C, LeMoult J, Heran MK, Silverberg ND. Pilot feasibility randomised controlled trial of cognitive-behavioural therapy for functional cognitive disorder after concussion. BMJ Neurol Open. 2024 Oct 11;6(2):e000666. doi: 10.1136/bmjno-2024-000666. eCollection 2024.
PMID: 39410977BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Noah D Silverberg, PhD
University of British Columbia
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
April 25, 2025
First Posted
May 4, 2025
Study Start
July 2, 2025
Primary Completion (Estimated)
April 30, 2028
Study Completion (Estimated)
April 30, 2029
Last Updated
July 30, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will not share