Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients

NCT06946537 | Recruiting

• 1 other identifier: H-25009586
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival. DRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood. This project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.

Conditions

Geriatric; Malnutrition; Length of Stay

Keywords

Geriatric; Disease-related malnutrition; Physiology; Acute illness; Deep phenotyping; Nutritional status

Outcome Measures

Primary Outcomes (1)

• Length of Hospital Stay

  Time (in hours) hospitalized from arrival to discharge

  From date of hospital admission untill discharge, assessed up to 2 months

Secondary Outcomes (3)

• Readmission

  Time to readmission 30 days from discharge

• Acute contact

  Time to acute contact 30 days from discharge

• Mortality

  Time to mortality 90 days from index admission

Study Arms (1)

The INSIGHT cohort

A geriatric cohort (age ≥ 65) established to investigate the coupling of phenotypical characteristics to nutritional and physiological status. The study intent to explore whether Disease-Related Malnutrition provides predictive value for patient prognosis based on specific phenotypic characteristics and establish different physiological stratifications to improve the identification of acutely admitted patients.

Other: Exposures and measurements

Interventions

Exposures and measurements OTHER

Anthropometry, Body composition (BIA), Nutritional screening (GLIM, SNAQ, NIS, NRS-2002), Functional tests, Seisomocardiography, Muscle strength, Blood tests, Fecal swabs, Indirect calorimetry Orientation-Memory-Concentration (OMC), Sarcopenia, Frailty (Clinical Frailty Scale), Comobidity, Polypharmacy, Portrait photo.

The INSIGHT cohort

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients acutely admitted at Bispebjerg Hospital

You may qualify if:

• Acutely admitted adults aged 65 years and above.
• Be able to comply with the study information, as assessed by the research personnel.
• Be able to understand Danish.

You may not qualify if:

• \<24 hours admission
• Terminal illness in end stage of life
• Patients with temporary civil person registration number (CPR)

Sponsors & Collaborators

• Bispebjerg Hospital: lead

Study Sites (1)

Bispebjerg Hospital

Copenhagen, 2400, Denmark

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood (plasma and serum) and feces (fecal swabs)

MeSH Terms

Conditions

Malnutrition

Interventions

Weights and Measures

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques

Central Study Contacts

Jacob B Jespersen, MSc

CONTACT

+4522321355; jacob.baekgaard.jespersen@regionh.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 25, 2025
• First Posted: April 27, 2025
• Study Start: May 12, 2025
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): November 1, 2028
• Last Updated: May 14, 2025

Record last verified: 2025-05

Locations

DK (1)