Associations Between Time to Reduction and Complications in Patients With Dislocated Total Hip Arthroplasty

NCT07132723 | Not Yet Recruiting

• 1 other identifier: HIP_REDUCTION
• Study Type: observational
• Target: 3,700
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to investigate the impact of time to closed reduction on both patient related and organizational factors. These include, length of stay, hospitalization, admission to intensive care unit, rehospitalizations, delirium, all-cause mortality, infection requiring hospital contact, and cardiovascular complications. It is also intended to investigate whether different anaesthetic strategies and airway management are associated with different complication rates. It is hypothesized that longer waiting time until reduction increase the postoperative length of stay, readmissions, and risk of complications.

Conditions

Closed Reduction; Arthroplasty, Replacement, Hip; Length of Stay

Outcome Measures

Primary Outcomes (1)

• Post procedure length of stay

  Post procedure length of stay from closed reduction until discharge from the hospital (hours)

  30 days after the closed reduction

Secondary Outcomes (7)

• All-cause mortality

  90 days after closed reduction

• Admissions to Intensive care unit

  30 days after the closed reduction

• Readmission

  30 days after discharge

• Delirium during admission

  From admission to discharge up to 30 days after closed reduction

• Acute kidney failure

  Post procedure until 30 days after discharge

Study Arms (1)

patients underwent closed reduction of dislocated THA

adults presenting with a dislocated THA, who underwent closed reduction in an operating theatre with anesthesiology being involved, in public hospitals

Other: Time in minutes from admission to closed reduction

Interventions

Time in minutes from admission to closed reduction OTHER

Time in minutes from admission to closed reduction measured as: From arriving time in the emergency department until the start of surgery in the operating theater.

Also known as: - Time of day, - Weekday vs. weekend, - Airway management, - Anesthesia method(s), - Neuromuscular blocking agent (Yes/No)

patients underwent closed reduction of dislocated THA

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The cohort contains all adults presenting with a dislocated THA, who underwent closed reduction in an operating theatre with anesthesiology being involved, in public hospitals in the Capital and Zealand Regions of Denmark. The study population is extracted from a dataset retrieved from the Electronic Health Record (EHR) system 'Sundhedsplatformen' (Epic Systems Corporation, WI, USA) from 1 January 2017 to 31 December 2024, including granular data from approximately 1.1 million anesthetic procedures

You may qualify if:

• Aged 18 years or older
• Presented to the emergency department with a dislocated total hip arthroplasty.
• Undergo closed reduction of the dislocated total hip arthroplasty in the operating theatre, with the involvement of the Department of Anesthesiology.

You may not qualify if:

• Were primarily booked for open surgical reduction.
• Did not have a complete case log (i.e. time of admission; referral to the operation theatre; anesthesia induction; discharge, etc.) and we were unable to recreate the log using simple code rules.

Sponsors & Collaborators

• Nordsjaellands Hospital: lead

Study Sites (1)

Department of Anesthesiology, North Zeeland Hospital

Hillerød, 3400, Denmark

Location

MeSH Terms

Interventions

Time; Airway Management; Neuromuscular Blocking Agents

Intervention Hierarchy (Ancestors)

Physical Phenomena; Therapeutics; Neuromuscular Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses

Central Study Contacts

Lars H Lundstrøm, MD, PhD

CONTACT

+4548296512; lars.hyldborg.lundstroem.02@regionh.dk

Rikke HF Bjulf, Research fellow

CONTACT

rikke.helene.frølund.bjulf.01@regionh.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 25, 2025
• First Posted: August 20, 2025
• Study Start: August 20, 2025
• Primary Completion: September 1, 2025
• Study Completion: October 1, 2025
• Last Updated: August 20, 2025

Record last verified: 2025-02

Locations

DK (1)