BID LTM Digital Intervention in Aging

NCT06916221 | Recruiting

• 2 other identifiers: 24-43268P30AG086635
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants. Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function. Participants will conduct study activities remotely (e.g., at-home):

1. 1.Baseline Assessment. Complete a series of cognitive assessments and surveys.
2. 2.Intervention. Engage in a digital intervention for up to 8 weeks.
3. 3.Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
4. 4.Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Conditions

Long-Term Memory; Inhibitory Control; Mild Cognitive Impairment

Keywords

cognitive training; cognitive aging; memory

Outcome Measures

Primary Outcomes (2)

• MDT change in recognition memory

  Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures

  baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests

• TOUR change in cued recall memory

  Psychometric test for proportion of details correctly recalled from recent autobiographical memory

  baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests

Secondary Outcomes (1)

• Cognitive Assessment change in working memory

  baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests

Study Arms (2)

Long Term Memory

ACTIVE COMPARATOR

Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge.

Behavioral: Long Term Memory

Worder

ACTIVE COMPARATOR

Multi-session cognitive intervention as a computer game that presents a word puzzle.

Behavioral: Worder

Interventions

Worder BEHAVIORAL

Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.

Worder

Long Term Memory BEHAVIORAL

Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.

Long Term Memory

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Minimum of 12 years of education
• English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
• Normal or corrected-to-normal vision
• Normal or corrected-to-normal hearing
• Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).

You may not qualify if:

• Under the age of 60
• Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of \>4
• Visually or hearing impaired without correction to normal
• Regularly (one or more times per week) practicing an instrument within the last year
• years or more of formal musical instrument training

Sponsors & Collaborators

• National Institute on Aging (NIA): collaborator
• University of California, San Francisco: lead

Study Sites (1)

University of California, San Francsico

San Francisco, California, 94158, United States

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Long Short Term Memory

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Recurrent Neural Networks; Neural Networks, Computer; Mathematical Concepts

Study Officials

• Peter E Wais, PhD

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Melissa Arioli, AB

CONTACT

(415) 502-7321; bid.core@ucsf.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: After recruitment, participants are randomly assigned to one of two arms, Participants and experimenters with whom they interact during the experiment are blind to treatment purpose of the randomly-assigned arm. First-level analysis of the data (baseline, post training and follow up) performed blind to the participant's arm.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized control trial

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: April 8, 2025
• Study Start: August 20, 2025
• Primary Completion (Estimated): January 31, 2028
• Study Completion (Estimated): July 31, 2028
• Last Updated: April 2, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF, ANALYTIC CODE

Locations

US (1)