NCT06918704

Brief Summary

The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are:

  1. 1.Does engagement in with a digital intervention improve working memory?
  2. 2.Does engagement in with a digital intervention improve inhibitory control?
  3. 3.Baseline Assessment. Complete a series of cognitive assessments and surveys.
  4. 4.Intervention. Engage in a digital intervention for up to 8 weeks.
  5. 5.Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
  6. 6.Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P75+ for not_applicable

Timeline
27mo left

Started Aug 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress25%
Aug 2025Jul 2028

First Submitted

Initial submission to the registry

March 24, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

April 9, 2025

Completed
4 months until next milestone

Study Start

First participant enrolled

August 15, 2025

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2028

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2028

Last Updated

April 1, 2026

Status Verified

March 1, 2026

Enrollment Period

2.5 years

First QC Date

March 24, 2025

Last Update Submit

March 31, 2026

Conditions

Working MemoryInhibitory ControlMild Cognitive Impairment (MCI)Aging

Keywords

Cognitive TrainingWorking MemoryMCIInhibitory ControlMild Cognitive ImpairmentAging

Outcome Measures

Primary Outcomes (1)

  • Working Memory

    Working memory performance will be assessed with a delayed match-to-sample task.

    Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

Secondary Outcomes (2)

  • Inhibitory Control

    Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

  • Inhibitory Control

    Immediately before the intervention, Immediately after the intervention, 6 months after the intervention

Study Arms (2)

Coherence Intervention

ACTIVE COMPARATOR

Participants in this arm will engage with the Coherence Intervention.

Behavioral: Coherence

Worder Intervention

ACTIVE COMPARATOR

Participants in this arm will engage with the Worder intervention.

Behavioral: Worder

Interventions

CoherenceBEHAVIORAL

Coherence is a music-based rhythm training app.

Coherence Intervention
WorderBEHAVIORAL

Worder is a word search app.

Worder Intervention

Eligibility Criteria

Age60 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Minimum of 12 years of education
  • English fluency
  • Normal or corrected-to-normal vision
  • Normal or corrected-to-normal vision
  • Medically healthy older adults including those with below-average cognitive performance or mild cognitive impairment patients without dementia

You may not qualify if:

  • Under the age of 60
  • Clinical diagnosis of neurological or psychiatric disorder
  • Visually or hearing impaired without correction to normal
  • Clinical diagnosis of dementia or AD8 score of \>3
  • Regularly (one or more times per week) practicing an instrument within the last year
  • or more years of formal musical instrument training

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94621, United States

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Tomography, Optical Coherence

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Tomography, OpticalOptical ImagingDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisTomographyInvestigative Techniques

Study Officials

  • Theodore Zanto, PhD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Melissa Arioli

CONTACT

(415) 506-7321Bid.Core@ucsf.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 24, 2025

First Posted

April 9, 2025

Study Start

August 15, 2025

Primary Completion (Estimated)

January 31, 2028

Study Completion (Estimated)

July 31, 2028

Last Updated

April 1, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

De-identified data to be shared includes demographic, cognitive assessments, survey, and behavioral outcomes.

Shared Documents
STUDY PROTOCOL, ICF, ANALYTIC CODE

Locations

US(1)