Wayfinding Intervention and Long-Term Memory

NCT05625425 | Recruiting

• 1 other identifier: 19-27586-B
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.

Conditions

Long-Term Memory Decline; Mild Cognitive Impairment

Keywords

amnestic MCI without dementia; cognitive training; cognitive aging

Outcome Measures

Primary Outcomes (4)

• MDT change in mnemonic discrimination

  Training-related change in Mnemonic Discrimination Task (MDT) score. MDT tests recognition memory for pairs of common objects (i.e., targets and lures), measuring the variable of the number of images identified as old (studied) or new (novel), and reports a composite index score (0.00 to 1.00) for accuracy post-training (T2) versus baseline (T1)

  baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2) providing for a composite score T2-T1

• TOUR change in recall

  Training-related change in recall of number of details in autobiographical memory from a narrated urban tour, such that a composite parametric score shows how many specific details were recalled post-training (T2) versus baseline (T1)

  baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2) providing for a composite score T2-T1

• Volumetric-based brain morphometry for gray and white matter

  Structural MRI T1 data will be analyzed in terms of volumetric-based morphometry, measuring the variables of cortical area.

  collected in association with Outcome 1, at baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2)

• Task-based cortical functional connectivity associated with mnemonic discrimination capability and in control of sustained visual attention

  functional MRI data will be analyzed in terms of beta-series correlations between co-active cortical regions of interest, measuring the variable of correlation of inter-trial variability across brain regions

  collected in association with Outcome 1, at baseline immediately before (T1) and post-assessment immediately after training regimen is completed (T2)

Secondary Outcomes (1)

• Remote Cognitive Module (RCM)

  baseline immediately before training regimen begins

Study Arms (4)

LabyrinthVR Scoot

EXPERIMENTAL

Multi-session cognitive intervention with VIVE high-resolution head-mounted display virtual reality computer game that presents an adaptive spatial wayfinding challenge. Game movement via handheld controllers.

Behavioral: LabyrinthVR software

Placebo Controls

PLACEBO COMPARATOR

Multi-session cognitive intervention with handheld tablet or wireless virtual reality headset presentation of commercially available, narrative computer games.

Behavioral: Placebo Games software

Labyrinth Tablet

EXPERIMENTAL

Multi-session cognitive intervention with tablet computer, displaying 2.5D version of Labyrinth game in an adaptive spatial wayfinding challenge. Game movement via on-screen control buttons.

Behavioral: Labyrinth Tablet software

Labyrinth VR wireless

EXPERIMENTAL

Multi-session cognitive intervention with QUEST head-mounted display virtual reality computer game using wireless technology to present an adaptive spatial wayfinding challenge. Game movement via handheld controllers.

Behavioral: Labyrinth VR wireless

Interventions

LabyrinthVR software BEHAVIORAL

Head-mounted display virtual reality game designed to induce environmental enrichment in an adaptive, highly engaging regimen of wayfinding in novel urban and village neighborhoods.

LabyrinthVR Scoot

Placebo Games software BEHAVIORAL

Commercially-available, narrative computer games marketed as cognitively enriching. Can be tablet-based or wireless VR headset-based.

Placebo Controls

Labyrinth Tablet software BEHAVIORAL

Tablet computer playing Labyrinth spatial wayfinding game in 2.5D

Labyrinth Tablet

Labyrinth VR wireless BEHAVIORAL

Wireless head-mounted display virtual reality game designed to induce environmental enrichment in an adaptive, engaging regimen of wayfinding in novel urban and village neighborhoods.

Labyrinth VR wireless

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• fluent speakers of English
• completed 12 or more years of education
• normal or corrected-to-normal vision
• dexterity to comfortably operate the scanner-compatible response box
• freedom from physical and neurological conditions contra-indicated for fMRI
• must confirm physical stamina and comfort for semi-weekly brisk 30-minute walks on level ground

You may not qualify if:

• use of psychotropic medications
• history of concussions or dizziness, vestibular or balance problems
• significant discomfort with virtual reality experiences

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

UCSF Mission Bay

San Francisco, California, 94158, United States

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Peter E Wais, PhD

  Neuroscape, Department of Neurology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Melissa Arioli

CONTACT

415-502-7321; twist.study@ucsf.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: After recruitment, participants are randomly assigned to treatment arms. Participants and experimenters with whom participants interact during the experiments are blind to the purpose of the randomly-assigned arm. First-level analysis performed blind to participant's treatment arm.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 10, 2022
• First Posted: November 23, 2022
• Study Start: January 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: May 7, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)