Relationship Between Magnesium Depletion Score and Extraction Socket Healing

NCT06891846 | Completed

• 1 other identifier: 24/738
• Study Type: observational
• Target: 111
• Locations: 1 country
• Sites: 1

Brief Summary

The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH). SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.

Conditions

Wound Healing; Magnesium Level; Wisdom Tooth Removal

Keywords

blood magnesium level; oral surgery; wound healing

Outcome Measures

Primary Outcomes (2)

• Magnesium depletion score (MDS)

  The MDS is calculated by aggregating four factors: 1. Diuretic use: Current use of diuretics is assigned 1 point. 2. PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point. 3. Kidney function: * If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned. * If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned. The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors.

  6 weeks

• Assessment of Wound healing (WH)

  Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling. The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing.

  6 weeks

Secondary Outcomes (1)

• Post-operative pain

  3 days

Study Arms (1)

Participants aged between 18-75 from both sexes

Systemically healthy participants, aged between 18-75 from both sexes

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Systemically healthy adult participants from both sexes, who were scheduled to undergo surgical extraction of lower impacted third molars, with a physical status classified as ASA I according to the American Society of Anesthesiologists (ASA).

You may qualify if:

• Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.

You may not qualify if:

• Refusal to consent
• Presence of chronic diseases
• Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
• Prior radiotherapy in the head and neck area
• Pregnancy
• Inability to self-evaluate, and inability to communicate verbally or in writing.

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

Sağlık Bilimleri Üniversitesi Tacirler Eğitim Vakfı Sultanbeyli Ağız ve Diş Sağlığı Hastanesi

Istanbul, Sultanbeyli, 34920, Turkey (Türkiye)

Location

Related Publications (5)

• Ye L, Zhang C, Duan Q, Shao Y, Zhou J. Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease. J Am Heart Assoc. 2023 Sep 19;12(18):e030077. doi: 10.1161/JAHA.123.030077. Epub 2023 Sep 8.

  PMID: 37681518 RESULT

• Xu Y, Qin Y, Lu H, Liu L, Huang W, Huang A, Ye Y, Shen H, Guo Z, Chen W. The magnesium depletion score is associated with increased likelihood of kidney stone disease among female adults. J Trace Elem Med Biol. 2024 Jul;84:127432. doi: 10.1016/j.jtemb.2024.127432. Epub 2024 Mar 12.

  PMID: 38489922 RESULT

• Wang J, Xing F, Sheng N, Xiang Z. Associations of the Dietary Magnesium Intake and Magnesium Depletion Score With Osteoporosis Among American Adults: Data From the National Health and Nutrition Examination Survey. Front Nutr. 2022 May 31;9:883264. doi: 10.3389/fnut.2022.883264. eCollection 2022.

  PMID: 35711538 RESULT

• Fan L, Zhu X, Rosanoff A, Costello RB, Yu C, Ness R, Seidner DL, Murff HJ, Roumie CL, Shrubsole MJ, Dai Q. Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults. J Nutr. 2021 Aug 7;151(8):2226-2235. doi: 10.1093/jn/nxab138.

  PMID: 34038556 RESULT

• Chen Y, Xiang X, Wu Y, Han S, Huang Z, Wu M. Magnesium Depletion Score Predicts Diabetic Retinopathy Risk among Diabetes: Findings from NHANES 2005-2018. Biol Trace Elem Res. 2023 Jun;201(6):2750-2756. doi: 10.1007/s12011-022-03384-3. Epub 2022 Aug 22.

  PMID: 35989402 RESULT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 4, 2025
• First Posted: March 24, 2025
• Study Start: September 10, 2025
• Primary Completion: October 22, 2025
• Study Completion: October 22, 2025
• Last Updated: November 24, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)