VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.

NCT06889116 | Completed

• 1 other identifier: 438(6-11)E2- 079/080
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean arterial pressure. Increasing cumulative fluid balance during the ICU stay has been found to be associated with negative outcomes including acute kidney injury (AKI) and hospital mortality. Venous excess ultrasound (VExUS) to assess the Doppler studies of renal, hepatic and portal veins along with the inferior venacava has been shown to reliably predict the incidence of AKI in certain ICU patient population more specifically in cardiorenal syndrome. The aim of this study was to correlate the incidence of AKI and VExUS scores in a mixed ICU population and hence determine the contribution of venous congestion on the causation of AKI in a general ICU. Methods: The patients included who have AKI at admission or developed AKI during their ICU stay were included. The definition of AKI used for this study was as defined by Kidney Disease: Improving Global Outcomes (KDIGO). Point of care VExUS scans were done on each patient at inclusion (day 0), then each day for a total of 4 days (day 1, 2 and 3), till initiation of renal replacement therapy, death or discharge form the ICU. Correlation between VExUS grades and creatinine clearances was explored as the primary objective.

Conditions

Acute Kidney Injury; VExUS

Keywords

VExUS; Acute Kidney Injury; Cumulative fluid balance; Point of Care Ultrasound

Outcome Measures

Primary Outcomes (1)

• To determine correlation between the VExUS score with creatinine clearance.

  At the end of Day 3 or initiation of renal replacement therapy or resolution of AKI, death or discharge from the ICU. whichever came first.

Study Arms (1)

Patients with AKI

Patients who are admitted with the diagnosis of AKI or develop AKI during their ICU stay

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who had AKI at the time of admission or who developed AKI during their ICU stay were screened for inclusion.

You may qualify if:

• Age ≥18 years
• Admitted to the adult ICUs of TUTH (ICU A and ICU B)
• Admitting diagnosis of AKI or who developed AKI during their ICU stay

You may not qualify if:

• Pregnancy
• Diagnosed case of chronic kidney disease
• Diagnosed case of cirrhosis/ portal hypertension
• Arrhythmias which would interfere with the acquisition and interpretation of the Doppler waveforms
• Inferior venacava thrombus
• Poor window for assessment

Sponsors & Collaborators

• Tribhuvan University Teaching Hospital, Institute Of Medicine.: lead

Study Sites (1)

Tribhuvan University Teaching Hospital

Mahārājgañj, Bagmati, 44600, Nepal

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: March 15, 2025
• First Posted: March 21, 2025
• Study Start: May 15, 2023
• Primary Completion: January 7, 2024
• Study Completion: January 11, 2024
• Last Updated: March 21, 2025

Record last verified: 2025-03

Locations

NE (1)