Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery

NCT05866250 | Completed

• 1 other identifier: DongZhang
• Study Type: observational
• Target: 467
• Locations: 1 country
• Sites: 7

Brief Summary

The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients. The main questions it aims to answer are:

• Are dynamic changes of RI within 24 or 48 hours associated with the prognosis of AKI (NO AKI, transient AKI, persistent AKI)?
• what are the influencing factors of changes in RI? Participants will measure values of RI in patients at admission (0 hour), after 24 hours and after 48 hours, respectively, and collect characters such as age, sex, vital signs, Apache II, diagnosis, renal function, applied drugs, fluid, 72-hour renal function and renal replacement, followed renal replacement and the mortality rate at 28 days.

Conditions

Acute Kidney Injury

Keywords

acute kidney injury; renal resistive index; prognosis; critically ill patients

Outcome Measures

Primary Outcomes (1)

• The prognosis of AKI

  NO AKI, transient AKI, persistent AKI. Transient AKI refers to the reduction in AKI stage ( (a decrease of serum creatinine, reversal of oliguria without diuretic therapy, and without need for renal replacement therapy) occurring with 72 hour after ICU admission. Persistent AKI refers to AKI without recovery occurring within 72 hours after ICU admission.

  72 hours

Secondary Outcomes (2)

• Recovery of kidney function

  28 days

• Mortality

  28 days

Study Arms (1)

critically ill patients

All newly admitted ICU patients

Diagnostic Test: Doppler-based renal resistive index

Interventions

Doppler-based renal resistive index DIAGNOSTIC_TEST

The kidney's interlobular or arcuate artery was preferentially selected and measured by pulse-wave Doppler.

critically ill patients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All the critically ill patients

You may qualify if:

• Patients admitted to the ICU within 24 h of admission.

You may not qualify if:

• Chronic kidney disease stage III-V;
• History of kidney transplantation;
• Previously known renal artery stenosis or renal vein thrombosis；
• Cardiac arrhythmia precluding renal Doppler measurement;
• Expected hospital stay \< 72 h；
• Pregnant patients
• Last, patients with hospital stays \< 72 h, since they could not be classified as having transient or persistent AKI according to our definitions, were secondarily excluded.

Sponsors & Collaborators

• The First Hospital of Jilin University: lead

Study Sites (7)

Jilin Province People's Hospital

Changchun, Jlin, 130021, China

Location

The First Hospital of Jilin University

Changchun, Jlin, 130021, China

Location

The Third Affiliated Hospital of Changchung University

Changchun, Jlin, 130021, China

Location

Dunhua City Hospital

Dunhua, Jlin, 133799, China

Location

Jilin Central Hospital

Jilin, Jlin, 132011, China

Location

Meihekou Central Hospital

Meihekou, Jlin, 135099, China

Location

Jilin Siping Central People's Hospital

Siping, Jlin, 132011, China

Location

Related Publications (5)

• Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honore PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015 Aug;41(8):1411-23. doi: 10.1007/s00134-015-3934-7. Epub 2015 Jul 11.

  PMID: 26162677 BACKGROUND

• Darmon M, Schortgen F, Vargas F, Liazydi A, Schlemmer B, Brun-Buisson C, Brochard L. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med. 2011 Jan;37(1):68-76. doi: 10.1007/s00134-010-2050-y. Epub 2010 Sep 23.

  PMID: 20862450 BACKGROUND

• Saade A, Bourmaud A, Schnell D, Darmon M; R2D2 Study Group. Performance of Doppler-Based Resistive Index and Semiquantitative Renal Perfusion in Predicting Persistent Acute Kidney Injury According to Operator Experience: Post Hoc Analysis of a Prospective Multicenter Study. Crit Care Med. 2022 Apr 1;50(4):e361-e369. doi: 10.1097/CCM.0000000000005372.

  PMID: 34678845 BACKGROUND

• Schnell D, Bourmaud A, Reynaud M, Rouleau S, Merdji H, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Darmon M. Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission. J Crit Care. 2022 Jun;69:153983. doi: 10.1016/j.jcrc.2021.12.017. Epub 2022 Jan 21.

  PMID: 35074631 BACKGROUND

• Darmon M, Bourmaud A, Reynaud M, Rouleau S, Meziani F, Boivin A, Benyamina M, Vincent F, Lautrette A, Leroy C, Cohen Y, Legrand M, Morel J, Terreaux J, Schnell D. Performance of Doppler-based resistive index and semi-quantitative renal perfusion in predicting persistent AKI: results of a prospective multicenter study. Intensive Care Med. 2018 Nov;44(11):1904-1913. doi: 10.1007/s00134-018-5386-3. Epub 2018 Oct 5.

  PMID: 30291377 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Dong Zhang, Director

  The First Hospital of Jilin University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: May 10, 2023
• First Posted: May 19, 2023
• Study Start: August 1, 2023
• Primary Completion: December 30, 2023
• Study Completion: March 1, 2024
• Last Updated: May 16, 2024

Record last verified: 2024-05

Locations

CN (7)