Correlation Between Preoperative NT-proBNP and Postoperative AKI

NCT06145347 | Completed

• 1 other identifier: KY-20232265-F-1
• Study Type: observational
• Target: 629
• Locations: 1 country
• Sites: 1

Brief Summary

Accurate preoperative AKI risk prediction is of great significance for improving patient outcomes. The use of preoperative NT-proBNP can provide a more precise assessment of the body's fluid load status, guide intraoperative and postoperative fluid management, and thus reduce fluid related postoperative complications. Given the potential association between ERAS and increased postoperative AKI, we hypothesize that preoperative NT-proBNP may be associated with the development of postoperative AKI in ERAS, and can improve the prediction of AKI beyond traditional clinical risk factors. This study aims to validate this hypothesis and provide evidence for using NT-proBNP to assess AKI risk before non cardiac surgery. Improve the predictive ability of clinical predictive models and optimize ERAS protocols to prevent postoperative AKI.

Conditions

Acute Kidney Injury

Keywords

NT-proBNP; AKI; ERAS; abdominal surgery

Outcome Measures

Primary Outcomes (1)

• Incidence of AKI assessed by KDIGO 2012 (Kidney Disease: Improving Global Outcomes)

  Postoperative incidence of AKI, serum creatinine increases≥ 0.3mg/dL (≥ 26.5 μ Mol/L) within 48 hours, or the serum creatinine increases to 1.5 times or more of the baseline value within 7 days.

  1 week

Secondary Outcomes (2)

• AKI grading assessed by KDIGO 2012 (Kidney Disease: Improving Global Outcomes)

  1 week

• Morbidity

  4 week

Study Arms (2)

Acute kidney injury group

Patients developed acute kidney injury.

Non-Acute kidney injury group

Patients didn't develope acute kidney injury.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with normal renal function undergoing elective abdominal surgery

You may qualify if:

• ≥18 years
• undergoing elective surgery
• Have a history of NT-proBNP and creatinine testing within 7 days before surgery

You may not qualify if:

• Patients undergoing chronic peritoneal or hemodialysis treatment; patients who have undergone kidney transplantation; preoperative serum creatinine levels\>4.5mg/dL (400 μ Mol/L) or end-stage renal disease patient (defined as glomerular filtration rate\<15ml • min-1 • 1.73m-2)
• Organ transplantation surgery
• Pregnant patients
• Surgical duration\<1 hour

Sponsors & Collaborators

• Xijing Hospital: lead

Study Sites (1)

Xijing Hospital

Xi'an, Shaanxi, 710032, China

Location

Related Publications (2)

• Ojo B, Campbell CH. Perioperative acute kidney injury: impact and recent update. Curr Opin Anaesthesiol. 2022 Apr 1;35(2):215-223. doi: 10.1097/ACO.0000000000001104.

  PMID: 35102042 BACKGROUND

• Zhang Z, Zheng Z, Nie H, Dong H, Lei C. Association between the preoperative N-terminal pro-B-type natriuretic peptide and acute kidney injury in gastrointestinal surgery patients managed with enhanced recovery strategy: a retrospective cohort study. Perioper Med (Lond). 2025 Apr 22;14(1):45. doi: 10.1186/s13741-025-00528-6.

  PMID: 40264198 DERIVED

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Hailong Dong

  Xijing Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, Head of Anesthesia Clinical Research Center, Xijing Hospital

Study Record Dates

• First Submitted: September 14, 2023
• First Posted: November 24, 2023
• Study Start: July 10, 2023
• Primary Completion: July 1, 2024
• Study Completion: July 1, 2024
• Last Updated: August 16, 2024

Record last verified: 2024-08

Locations

CN (1)