NCT06874829

Brief Summary

Investigators used a randomized controlled crossover design to compare the effect of blood flow restriction (BFR) and electrical muscle stimulation (EMS) protocols on post-activation performance enhancement (PAPE) in multi-joint versus single-joint exercises. Participants took part in six test sessions 72 hours apart. In the BFR group, 50% of the arterial occlusion pressure (AOP) was used. In the EMS group, a 75 Hz current was applied. In the Low Resistance exercise group, only exercise was performed without any condition. Bench press (multi-joint) and triceps push-down (single-joint) exercises were used in the conditions.

Trial Health

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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
15

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 10, 2025

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

February 25, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

March 13, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 9, 2025

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 29, 2025

Completed
Last Updated

March 13, 2025

Status Verified

March 1, 2025

Enrollment Period

6 months

First QC Date

February 25, 2025

Last Update Submit

March 7, 2025

Conditions

Keywords

Post-activation performanceBlood Flow Restriction ExercisevolleyballHand Grip StrengthService Speed

Outcome Measures

Primary Outcomes (2)

  • Service speed

    Service speed will assess by standard radar apparatus (Net Playz Smart Pro Speed Radar, USA) and will record in km/h.

    From baseline to the end of treatment at 8 weeks

  • Hand Grip strength

    Hand grip strength will assess by hand grip dynamometer (Takei 5,101, Tokyo, Japan) and will record in kg.

    From baseline to the end of treatment at 8 weeks

Other Outcomes (6)

  • Bench Press 1Repetition maximum Test

    Baseline

  • Triceps Push Down 1 repetition maximum Test

    Baseline

  • Anthropometric Measurements 1

    Baseline

  • +3 more other outcomes

Study Arms (3)

Blood flow restriction

ACTIVE COMPARATOR

In the BFR group, 50% of the arterial occlusion pressure (AOP) was used.Bench press (multi-joint) and triceps push-down (single-joint) exercises were used in the conditions.

Other: Blood Flow Restriction

Electrical muscle stimulation

ACTIVE COMPARATOR

In the EMS group, a 75 Hz current was applied. Bench press (multi-joint) and triceps push-down (single-joint) exercises were used in the conditions.

Other: Electrical Muscle Stimulation

Low Load Resistance Exercise

ACTIVE COMPARATOR

In the Low Resistance Exercise group, only exercise was performed without any condition (BFR or EMS. Bench press (multi-joint) and triceps push-down (single-joint) exercises were used in the conditions.

Other: Low-Load Resistance Exercise

Interventions

EMS will be applied bilaterally to the wrist flexor and elbow extensor muscles using a portable EMS stimulator (Compex Rehab 400, Medicompex SA, Ecublens, Switzerland). Four 2 mm thick, self-adhesive electrodes (5x5 cm) will be placed on the superficial aspect of each muscle group. The athletes will simultaneously receive EMS intervention with a pulse frequency of 75 Hz and a duration of 400 μs (19 seconds rest between pulses) during bench press and triceps pushdown exercises. Bench press and triceps push down exercises will be performed with 30% 1TM, 30-15-15-15 repetitions and thirty seconds rest between sets.

Also known as: EMS
Electrical muscle stimulation

The arterial occlusion pressures (AOP) of the athletes randomized to the experimental group will be obtained automatically with the digital LED display CAC device BFR Unit (Fit Cuffs BFR Unit, Denmark). The AOP pressure device BFR Unit (Fit Cuffs BFR Unit, Denmark) will be used to apply 50% occlusion pressure during exercise. Bench press and triceps push down exercises will be performed with 30% 1TM, 30-15-15-15 repetitions and thirty seconds rest between sets.

Also known as: BFR
Blood flow restriction

Bench press and triceps pushdown exercises will be performed with 30% 1RM, 30-15-15-15 repetitions and 30 seconds rest between sets.

Also known as: LL-RE
Low Load Resistance Exercise

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Being healthy
  • Male volleyball athletes
  • Willing to maintain the intervention for all sessions

You may not qualify if:

  • Being under 18 years old
  • Having a chronic disease
  • Contraindication for Electromyostimulation (EMS)
  • Contraindication for Blood Flow Restriction (BFR)
  • Contraindications for exercise

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Karabuk University

Karabük, Turkey, 78200, Turkey (Türkiye)

Location

Related Publications (1)

  • Keskin K, Akcay N, Ozmen T, Contarli N, Yildiz KC, Sofuoglu C, Kamis O, Rolnick N, de Queiros VS, Montoye A. Effects of different pre-exercise strategies on jumping performance in female volleyball players. J Sports Med Phys Fitness. 2025 Jan;65(1):59-68. doi: 10.23736/S0022-4707.24.16196-8. Epub 2024 Oct 3.

    PMID: 39360986BACKGROUND

MeSH Terms

Interventions

Blood Flow Restriction Therapy

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy Modalities

Study Officials

  • Neslihan AKCAY, Doctorate

    Karabuk University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Masking Details
Participants were strictly separated and think their intervention is the main intervention. The same is true for care providers. Outcome assessors were unaware of participant group status and were not allowed to ask correspondingly.
Purpose
TREATMENT
Intervention Model
CROSSOVER
Model Details: Crossover Assignment
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assoc. Prof. Dr.

Study Record Dates

First Submitted

February 25, 2025

First Posted

March 13, 2025

Study Start

February 10, 2025

Primary Completion

August 9, 2025

Study Completion

October 29, 2025

Last Updated

March 13, 2025

Record last verified: 2025-03

Locations