The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

NCT06739148 | Recruiting

• 1 other identifier: A-ER-113-089
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Conditions

Blood Flow Restriction Therapy; Neuromuscular Electrical Stimulation (NMES); Laser Therapy, Low-Level; Muscle Strength

Keywords

Muscle strength; Training; Low-level laser Therapy; Blood flow restriction; Neuromuscular electrical stimulation

Outcome Measures

Primary Outcomes (4)

• Myoton

  Non-dominant hand extensor digitorum muscle belly parameters of static mechanical properties of muscles (Tone, Stiffness, Relaxation, Creep, etc.)

  before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

• Mechanomyogram

  Recording of extensor digitorum muscle microshock waves during contraction

  before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

• Multi-electrode surface EMG

  Record muscle activity during contraction

  before training, at the end of 3 weeks training

• Dynamometer System

  Measurement to track the degree of force applied by a non-dominant hand.

  before training, 1week of training, 2 weeks of training, at the end of 3 weeks training

Study Arms (2)

LLLT+BFR+NMES

EXPERIMENTAL

LLLT: low-level laser therapy BFR: blood flow restriction NMES:neuromuscular Electrical Stimulation 35 min/time, 3 times/weeks, 3 weeks

Device: Low Level Laser Therapy; Device: blood flow restriction; Device: Neuromuscular Electrical Stimulation

BFR+NMES

EXPERIMENTAL

BFR: blood flow restriction NMES:Neuromuscular Electrical Stimulation 35 min/time, 3 times/weeks, 3 weeks

Device: blood flow restriction; Device: Neuromuscular Electrical Stimulation

Interventions

Low Level Laser Therapy DEVICE

Low-level laser therapy can increase cellular energy production, making it useful as a pre-conditioning treatment to prevent muscle contraction fatigue or as a post-contraction therapy to accelerate fatigue recovery.

LLLT+BFR+NMES

blood flow restriction DEVICE

Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).

BFR+NMES; LLLT+BFR+NMES

Neuromuscular Electrical Stimulation DEVICE

It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.

BFR+NMES; LLLT+BFR+NMES

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
• Normal vision range after visual correction.

You may not qualify if:

• Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
• History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
• Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
• Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

Sponsors & Collaborators

• National Cheng-Kung University Hospital: lead

Study Sites (1)

National Chen Kong University Hospital, Tainan

Tainan, Taiwan

RECRUITING

MeSH Terms

Interventions

Low-Level Light Therapy; Blood Flow Restriction Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Physical Therapy Modalities

Study Officials

• Ing-Shiou Hwang, PhD

  NCKU, Institute of Allied Health Sciences

  STUDY CHAIR

Central Study Contacts

Ing-Shiou Hwang, PhD

CONTACT

+886 62353535; ensureh@gmail.com

Pei-Fen Li, Master

CONTACT

+886 62353535; abbylee52034@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: December 18, 2024
• Study Start: October 1, 2024
• Primary Completion: July 31, 2025
• Study Completion: July 31, 2025
• Last Updated: December 18, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)