NCT06869148

Brief Summary

The older population is getting older and growing in size worldwide. This requires healthcare to adapt to meet the complex medical and nursing needs of the older patient group. As older patients have varying health conditions with different levels of functions, their premise to handle acute, unexpected illness differs as well. This complicates matters for healthcare, especially emergency departments (ED) where resource allocation and identifying patients that are at greatest risk of negative health outcomes must be prioritized in a limited time. When patients present to the ED, initial triage information such as vital signs and reason for visit determines the triage acuity for the patient. In Linköping, and large parts of Sweden, the triage tool RETTS (Rapid Emergency Triage and Treatment System) is used, where the highest priority is red (priority 1), then orange (priority 2), yellow (priority 3), green (priority 4) and blue (priority 5). However, this can be misleading when assessing older patients due to altered physiology with natural ageing and older patients are known to be under-triaged with existing triage systems. The variation in functional capacity in older patients does not necessarily correlate with comorbidities and age and has been condensed to the term 'frailty'. It has been proposed that the frailty level corresponds more to biological age rather than chronological age. Frailty increases the risk of adverse outcomes such as falls, the need of in-hospital care, institutionalization, and mortality in which the risk is increased even in low acuity illnesses. Frailty can be assessed by various means and based on the theory of cumulative deficit, frailty assessment instruments have been developed where frailty level increases with the amount of help needed from others. Different instruments have been compared in the ED and the Clinical Frailty Scale (CFS) have been deemed fit due to it being practical in a busy environment. The scale consists of 9 points where 9 is the highest level of frailty and the scale is usually dichotomized into "robust" and "living with frailty" where 5 points or above constitutes frailty. The prognostic value of CFS has previously been studied in the ED of University hospital of Linköping in Sweden with results indicating that the instrument should be used as an additional risk assessment in the ED. Older patients often present with vague and complex symptoms to th ED, which could lead to prolonged ED stay due to the need of extensive medical workup or therapy. Long ED stays have been shown to increase both morbidity and mortality in older patients as well as risk of delirium and complications relating to care, especially in individuals living with frailty. In order to decrease the adverse events, aim to shorten ED length of stay (ED LOS) should therefore be a reasonable goal in clinical improvement work. Early identification of frailty in the ED may lead to rapid assessments and streaming of care for older patients which have shown to statistically significantly decrease ED LOS, which is why an early assessment by a physician potentially could decrease overall ED LOS. However, it is unknown how early assessed frailty could affect the ED visit itself. In the beginning of 2025, the Emergency department of University hospital of Linköping launched a local guideline which recommended that patients aged 65 years or older visiting the ED should be assessed with CFS as early as possible, preferably in connection to triage. If the patients were assessed as living with frailty, the frailty score should be stated in the electronical overview of ED patients. The patient's needs of care should be induvidualized according to frailty level and the responsible clinical team should aim to decrease the ED length of stay for older patients living with frailty. This study focuses on the outcomes of this newly implemented routine and aims to answer if recommended prioritization of older ED patients living with frailty leads to decreased ED LOS. Furthermore the study investigates if the clinical guidelines have an impact on time to the first assessment by a physician, admission rate, in-hospital length of stay, and mortality at 90 days

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,217

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 27, 2025

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

March 3, 2025

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 11, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2025

Completed
Last Updated

August 26, 2025

Status Verified

March 1, 2025

Enrollment Period

6 months

First QC Date

March 3, 2025

Last Update Submit

August 25, 2025

Conditions

Keywords

Clinical frailty scaleCFSFrailty assessmentTriageEmergency departmentLength of stayphysician prioritizationphysician prioritisation

Outcome Measures

Primary Outcomes (1)

  • ED length of stay

    Length of stay in the ED measured in hours and minutes (data will be collected from the electronic health record)

    From enrollment until end of inclusion, approximately 4-8 weeks for each group

Secondary Outcomes (5)

  • Time to the first assessment by a physician

    From enrollment until end of inclusion, approximately 4 weeks for each group

  • Admission rate

    From enrollment until end of inclusion, approximately 4-8 weeks for each group

  • In-hospital length of stay

    From enrollment until end of inclusion, approximately 4-8 weeks for each group

  • Mortality up to 90 days

    From enrollment until end of inclusion, approximately 4-8 weeks for each group

  • Difference in ED length of stay between patients in different triage categories

    From enrollment until end of inclusion, approximately 4-8 weeks for each group

Study Arms (2)

Control group

Patients aged 65 years or older visisting the ED who have been assessed for frailty. The control group were included before implementation of the local guidelines.

Intervention group

Patients aged 65 years or older visisting the ED who have been assessed for frailty. The intervention group were included after the implementation of the local guidelines.

Other: Prioritized assessment for older patients living with frailty

Interventions

In the beginning of 2025, the Emergency department of University hospital of Linköping launched a clinical guideline which stated that patients aged 65 years or older should be assessed with CFS as early as possible, preferably in connection to triage. If the patients were assessed as living with frailty, the frailty score should be stated in the electronical overview of ED patients. The patient's needs of care should be met according to frailty level and the responsible clinical team should aim to decrease the ED length of stay for older patients living with frailty.

Also known as: Local guidelines regarding frailty in the Emergency Department
Intervention group

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients visiting the ED in Linköping in the age of 65 years or older who have been assessed by CFS

You may qualify if:

  • years of age or older
  • Assessed by CFS with the score being documented in the electronic journal

You may not qualify if:

  • Under the age of 65 years of age
  • Not assessed by CFS
  • Refusal of participation in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Emergency Medicine, University hospital

Linköping, Östergötland County, 581 85, Sweden

Location

Related Publications (2)

  • Wretborn J, Munir-Ehrlington S, Horlin E, Wilhelms DB. Addition of the clinical frailty scale to triage tools and early warning scores improves mortality prognostication at 30 days: A prospective observational multicenter study. J Am Coll Emerg Physicians Open. 2024 Sep 9;5(5):e13244. doi: 10.1002/emp2.13244. eCollection 2024 Oct.

    PMID: 39253302BACKGROUND
  • Munir Ehrlington S, Horlin E, Toll John R, Wretborn J, Wilhelms D. Frailty is associated with 30-day mortality: a multicentre study of Swedish emergency departments. Emerg Med J. 2024 Aug 21;41(9):514-519. doi: 10.1136/emermed-2023-213444.

    PMID: 39053972BACKGROUND

MeSH Terms

Conditions

FrailtyEmergencies

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and SymptomsDisease Attributes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator Daniel Wilhelms , PhD, MD . Department of Emergency Medicine in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

Study Record Dates

First Submitted

March 3, 2025

First Posted

March 11, 2025

Study Start

January 27, 2025

Primary Completion

July 31, 2025

Study Completion

July 31, 2025

Last Updated

August 26, 2025

Record last verified: 2025-03

Locations