NCT04888884|Completed
Loss of Independence - a Rapid Alternative to Frailty Screening in a Swedish ED Setting
Loss of Independence (LOI) - a Rapid Alternative to Frailty Screening in a Swedish Emergency Department Setting
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Loss of Independence (LOI) - a Rapid Alternative to Frailty Screening in a Swedish Emergency Department Setting
Sponsor study identifier
observational
1,800
1 country
3
Study Start
September 27, 2021
Actual (reported)Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2021
Actual (reported)This prospective observational study will investigate the correlation of a surrogate marker of frailty in relation to serious outcomes. Serious outcomes are defined as: mortality within 30 days, admission to hospital, length of stay in the Emergency Department (ED), in-hospital Length of Stay and revisits to the ED. The exposure, frailty, will be assessed according to Loss of Independence (LOI) a possible low-cost quick tool to identify frailty in patients. The study population will be ED patients, \>65 years of age in a Swedish regional health care system (Region Östergötland, Sweden), comprising three EDs in Linköping, Norrköping and Motala. The outcomes will be compared according to the degree of frailty and censored over 7, 30 and 90 days.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2021
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 11, 2021
Actual (reported)May 17, 2021
Actual (reported)September 27, 2021
Actual (reported)December 31, 2021
Actual (reported)December 31, 2021
Actual (reported)Mortality in 30 Days
Investigate level of mortality in cohort at 30 days
All cause mortality up to 30 days from index visit
Mortality in 7 and 90 days
All cause mortality up to 90 days from index visit
Admission to hospital
Hospital admission on index visit, censored at 90 days
ED length of stay
Length of stay at ED, censored at 4 days
In-hospital length of stay
In-hospital length of stay from index visit, censored at 90 days
Revisits to the ED
Number of newly registered visits to the ED after index visit, censored at 90 days
Patients of all gender at the age of ≥ 65 years seeking medical care at the three EDs in Region Östergötland.
University Hospital Linköping
Linköping, Östergötland County, 58185, Sweden
Medicinska Specialist Kliniken i Motala
Motala, Östergötland County, Sweden
Vrinnevisjukhuset i Norrköping
Norrköping, Östergötland County, Sweden
Kellett J, Deane B. The Simple Clinical Score predicts mortality for 30 days after admission to an acute medical unit. QJM. 2006 Nov;99(11):771-81. doi: 10.1093/qjmed/hcl112. Epub 2006 Oct 17.
Kellett J, Deane B, Gleeson M. Derivation and validation of a score based on Hypotension, Oxygen saturation, low Temperature, ECG changes and Loss of independence (HOTEL) that predicts early mortality between 15 min and 24 h after admission to an acute medical unit. Resuscitation. 2008 Jul;78(1):52-8. doi: 10.1016/j.resuscitation.2008.02.011. Epub 2008 Apr 10.
Daniel Wilhelms, PhD
Linkoeping University
1,800 participants (actual enrollment reported by the registry).
First Submitted
May 11, 2021
First Posted
May 17, 2021
Study Start
September 27, 2021
Actual (reported)Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs
Contact the study team to confirm eligibility.
Brabrand M, Folkestad L, Clausen NG, Knudsen T, Hallas J. Risk scoring systems for adults admitted to the emergency department: a systematic review. Scand J Trauma Resusc Emerg Med. 2010 Feb 11;18:8. doi: 10.1186/1757-7241-18-8.
Brabrand M, Lassen AT, Knudsen T, Hallas J. Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score): a prospective cohort study with external validation. PLoS One. 2015 Apr 13;10(4):e0122480. doi: 10.1371/journal.pone.0122480. eCollection 2015.
Rylance J, Baker T, Mushi E, Mashaga D. Use of an early warning score and ability to walk predicts mortality in medical patients admitted to hospitals in Tanzania. Trans R Soc Trop Med Hyg. 2009 Aug;103(8):790-4. doi: 10.1016/j.trstmh.2009.05.004. Epub 2009 Jun 21.
Berian JR, Mohanty S, Ko CY, Rosenthal RA, Robinson TN. Association of Loss of Independence With Readmission and Death After Discharge in Older Patients After Surgical Procedures. JAMA Surg. 2016 Sep 21;151(9):e161689. doi: 10.1001/jamasurg.2016.1689. Epub 2016 Sep 21.
Primary Completion
December 31, 2021
Actual (reported)Study Completion
December 31, 2021
Actual (reported)Last Updated
May 4, 2022
Record last verified: 2022-05
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