Predictive Ability of Different Frailty Indices for Postoperative Infections in Elderly Patients

NCT06985771 | Completed DMC

• 1 other identifier: PLAGH-AOC-L08
• Study Type: observational
• Target: 10,536
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we extracted data from the patients medical record within the cohort to compare five existing frailty indices: the 5-Item Modified Frailty Index (mFI-5), the Electronic Frailty Index (eFI), the Frailty Index based on Comprehensive Geriatric Assessment (FI-CGA), the Frailty Risk Assessment Instrument for the Elderly based on Laboratory and Clinical Indicators (FRAIL), and the Hospital Frailty Risk Score (HFRS). The study aims to evaluate the predictive values of each electronic frailty index for the incidence of postoperative infection-related adverse events. This includes the primary outcome of infection events occurring within 30 days and the secondary outcome of the correlations among the five frailty indices.

Conditions

Postoperative Infections; Frailty

Keywords

Frailty; Postoperative Infection; elderly patients

Outcome Measures

Primary Outcomes (1)

• Postoperative infection events within 30 days postoperatively

  Within 30 days postoperatively

Study Arms (1)

Postoperative infection or not

Postoperative infection within 30 days postoperatively versus no infection.

Other: Observational study, with no intervention.

Interventions

Observational study, with no intervention. OTHER

Observational study, with no intervention.

Postoperative infection or not

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients aged 65 and older who were involved in the prospective cohort of postoperative adverse events in elderly patients from April 2020 to April 2022.

You may qualify if:

• Aged 65 and above
• Patients who underwent Non-Cardiac surgeries and anesthesia

You may not qualify if:

• Patients who underwent surgery within 30 days before the current procedure;
• Patients with missing baseline demographic data;
• Patients with incomplete medical records that resulted in the inability to fully assess all five frailty indices;
• Patients with missing data related to primary and secondary outcomes after surgery.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead
• The First Medical Center of Chinese PLA General Hospital: collaborator

Study Sites (1)

The First Medical Center of Chinese PLA General Hospital

Beijing, Beijing Municipality, 100857, China

Location

MeSH Terms

Conditions

Frailty

Interventions

Observation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Jingsheng Lou, Doctor

  The First Medical Center of Chinese PLA General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Chief Anesthesiologist

Study Record Dates

• First Submitted: May 15, 2025
• First Posted: May 22, 2025
• Study Start: March 1, 2025
• Primary Completion: April 10, 2025
• Study Completion: May 6, 2025
• Last Updated: May 22, 2025

Record last verified: 2025-05

Locations

CN (1)