The Effect of Norepinephrine on the Development of Pressure Injury

NCT06860308 | Completed

• 1 other identifier: NR24022025
• Study Type: observational
• Target: 289
• Locations: 1 country
• Sites: 1

Brief Summary

Norepinephrine mainly increases mean arterial pressure among intensive care patients. It may be an essential risk factor in developing pressure injuries. However, there are still conflicting findings in the literature. This study aimed to examine the effect of norepinephrine infusion on the development of pressure injuries among patients in adult intensive care. This retrospective and correlational study was conducted between March 2021- May 2022. The electronic patient data were obtained from 289 adult patients (Case group n=149; control group n=149) treated with and without norepinephrine in the intensive care unit, respectively. The demographic and clinical characteristics were evaluated using descriptive statistical methods (number, percentage, mean, standard deviation). A logistic regression model was established to estimate the dependent variable (development of pressure injury) with the independent variables.

Conditions

Pressure Injury

Keywords

pressure injury; norepinephrine; vasopressor; intensive care; development

Outcome Measures

Primary Outcomes (1)

• development of pressure injury after admission to intensive care unit until discharge

  The development of pressure injuries after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. . This is a retrospective study, so there is no specific time. We specified time frame details below.

  after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. .

Study Arms (2)

Case Group

Patients with norepinephrine infusion in the intensive care unit,

Control group

Patients without norepinephrine in the intensive care unit

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population included all adult critically ill patients hospitalized in the 16-bed Adult ICU at the university hospital in Istanbul, Turkey. The ICU was 3rd level ICU where medical and surgical patients received life support treatments and care at the highest level. The study was conducted between May 2020 and March 2021.

You may qualify if:

• The sample consisted of all patients
• over 18 years old
• who did not have pressure injuries upon admission to the intensive care unit. Patients who received norepinephrine and received norepinephrine infusion for at least 48 hours during their stay in ICU were included in the case group (n=149), and patients who did not receive an infusion were included in the control group (n=140).

You may not qualify if:

• The sample excluded of all patients
• less than 18
• who have pressure injuries during admission
• who had norepinephrine infusion less than48 hours during their stay in the intensive care unit.

Sponsors & Collaborators

• Koç University: lead

Study Sites (1)

Koç University Hospital

Istanbul, Istanbul, 34010, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pressure Ulcer

Condition Hierarchy (Ancestors)

Skin Ulcer; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 25, 2025
• First Posted: March 6, 2025
• Study Start: December 1, 2024
• Primary Completion: January 31, 2025
• Study Completion: February 20, 2025
• Last Updated: March 6, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)