Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables in Individuals with Chronic Pain?

NCT06851208 | Not Yet Recruiting

• 1 other identifier: 2024-07781-01 ethic approval
• Study Type: interventional
• Target: 180
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect in individuals with chronic pain.

Conditions

Pain Thresholds; Pain Intensity

Keywords

Pressure pain thresholds; Pain; Emotions

Outcome Measures

Primary Outcomes (1)

• Pressure pain thresholds

  Description: Pressure pain thresholds will be measured i kPa with a handheld algometer (Somedic AB).

  Day 1: baseline PPTs are measured, intervention 2.20 min follows and intervention PPTs are measured directly after the intervention. Recruitment for single appointments for each participant will take place for 4 months.

Secondary Outcomes (3)

• Pain tolerance (time in seconds the left hand is immersed in cold water 1 degree C).

  Day 1: During a single session (30 min), the participant will keep their hand immersed in cold water for as long as possible while watching a video. This time will be measured in seconds.

• Pain intensity on the NRS

  Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS (Numerical Rating Scale) after the intervention. Participants will be successively recruited for single session appointments for 4 months.

• Pain-related negative affect on the NRS-A

  Day 1: Pain intensity will be estimated at single session appointments (30 min) on the NRS-A (Numerical Rating Scale-Anxiety) after the intervention. Participants will be successively recruited for single session appointments for 4 months.

Study Arms (1)

Experimental: Negative emotion, positive emotion, neutral emotion, control with experimental pain

EXPERIMENTAL

Arm Description: The intervention includes either a negatively emotionally valenced video, a positively emotionally valenced video, a neutrally emotionally valenced video and experimental pain from the cold pressor test that are simultaneosly applied.

Other: Emotional intervention

Interventions

Emotional intervention OTHER

Emotional intervention Description: The participant will watch a short video-clip with negative emotional content while simultaneously experience experimentally induced pain.

Experimental: Negative emotion, positive emotion, neutral emotion, control with experimental pain

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Above 18 years of age
• Fluent in Swedish
• Persistent chronic pain with duration \> 6 months

You may not qualify if:

• \- Known neurological disease

Sponsors & Collaborators

• Linnaeus University: lead

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Helena Gunnarsson, Dr

CONTACT

+46708432509; helena.gunnarsson@lnu.se

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Model Details: Within-subjects design

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: February 28, 2025
• Study Start: March 1, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: February 28, 2025

Record last verified: 2025-02