Do Emotions and Pain Combined Affect Mechanical Pain Thresholds and Other Pain-related Variables

NCT06840743 | Completed

• 1 other identifier: Dnr 2024-03992-01
• Study Type: interventional
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate if different emotional states could influence mechanical pain thresholds and other pain - related variables such as pain tolerance, pain intensity and pain - related negative affect.

Conditions

Pain Thresholds

Keywords

Pressure Pain Thresholds; Pain; Emotions

Outcome Measures

Primary Outcomes (1)

• Pressure pain thresholds (PPTs)

  Pressure pain thresholds will be measured i kPa with a handheld algometer (Somedic AB).

  For each participant, baseline PPTs are measured, intervention follows and intervention PPTs are measured. This will be conducted at one appointment (30 min) for each participant. Recruitment for single appointments will take place for 18 months.

Secondary Outcomes (3)

• Pain tolerance (time in seconds the left hand is immersed in cold water 1 degree C).

  At a single session (30 min), the participant will keep their hand immersed in cold water for as long as possible while watching a video. This time will be measured in seconds. Participants are successively recruited for single appointmentsfor 18 months.

• Pain intensity on the NRS

  The pain intensity will be estimated at every single session appointment (30 min) after the intervention on the NRS (Numerical Rating Scale). The participants will be successively recruited for single session appointments for 18 months.

• Pain-related negative affect on the NRS-A

  Negative affect will be estimated at every single test session (30 min) on the NRS-A (Numerical Rating Scale-Anxiety) directly after the intervention. The participants will be successively recruited for single session appointments during 18 months.

Study Arms (1)

Negative emotion, positive emotion, neutral emotion, control with experimental pain

EXPERIMENTAL

The intervention includes either a negatively emotionally valenced video, a positively emotionally valenced video, a neutrally emotionally valenced video and experimental pain from the cold pressor test that are simultaneosly applied.

Other: Emotional intervention

Interventions

Emotional intervention OTHER

The participant will watch a short video-clip with negative emotional content while simultaneously experience experimentally induced pain.

Negative emotion, positive emotion, neutral emotion, control with experimental pain

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Above 18 years of age
• Fluent in Swedish.

You may not qualify if:

• Pain anywhere in body during the test session
• Known neurological disease.

Sponsors & Collaborators

• Linnaeus University: lead

Study Sites (1)

Linnaeus University

Vaxjo, 343 32, Sweden

Location

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Model Details: Within-subjects design

Study Record Dates

• First Submitted: February 12, 2025
• First Posted: February 21, 2025
• Study Start: August 31, 2025
• Primary Completion: October 30, 2025
• Study Completion: October 30, 2025
• Last Updated: December 30, 2025

Record last verified: 2025-02

Locations

SE (1)