Low Flow Anesthesia Without Initial High Flow Phase
Comparison of Low Flow Anesthesia With and Without Initial High Flow Phase
1 other identifier
interventional
80
1 country
1
Brief Summary
The aim of the study is to compare the effectiveness of conventional low flow anesthesia (LFA) with initial high fresh gas flow ( 4L/min) for 10 minutes and LFA with fixed fresh gas flow rate (1L/min).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 16, 2019
CompletedFirst Posted
Study publicly available on registry
May 20, 2019
CompletedStudy Start
First participant enrolled
May 22, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 2, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 2, 2019
CompletedJuly 10, 2019
July 1, 2019
1 month
May 16, 2019
July 9, 2019
Conditions
Outcome Measures
Primary Outcomes (2)
The time required to reach 0.7 MAC
perioperative
number of adjustments made to the vaporizer settings
MAC will be held between 0.6-0.8 with adjustments at the vaporizer
perioperative
Secondary Outcomes (1)
anesthetic agent consumption
perioperative
Study Arms (2)
Conventional group
ACTIVE COMPARATORAfter standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 6% with fresh gas flow rate 4 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 1% higher value than the EtAA concentration required to achieve 0.7 MAC. And after 10 minutes fresh gas flow rate will be reduced to 1L/min.
Fixed Fresh Gas Flow Rate group
ACTIVE COMPARATORAfter standart intravenous anesthesia induction end endotracheal intubation desflurane vaporizer will be set at 18% with fresh gas flow rate 1 L/min (50% O2, 50% air) until the EtAA concentration reaches 0.7 MAC (minimum alveolar concentration) Then, the desflurane vaporizer will be at a 2% higher value than the EtAA concentration required to achieve 0.7 MAC.
Interventions
During the initial wash-in period 4 L/min Fresh gas flow will be used.
Fresh gas flow rate will be 1 L/min throughout the procedure.
Eligibility Criteria
You may qualify if:
- ASA 1-3
- scheduled for surgery under general anesthesia with endotracheal intubation
You may not qualify if:
- hemodynamic instability
- emergency cases
- expected anesthesia duration \< 60 min
- patient refusal
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kahramanmaras Sutcu Imam University
Kahramanmaraş, In the USA Or Canada, Please Select..., 46100, Turkey (Türkiye)
Related Links
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
May 16, 2019
First Posted
May 20, 2019
Study Start
May 22, 2019
Primary Completion
July 2, 2019
Study Completion
July 2, 2019
Last Updated
July 10, 2019
Record last verified: 2019-07
Data Sharing
- IPD Sharing
- Will not share