NCT05661045|Completed
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Sponsor study identifier
observational
130
1 country
1
Study Start
January 2, 2023
Actual (reported)Primary Completion
June 2, 2024
Actual (reported)Study Completion
June 2, 2024
Actual (reported)In contrast to toxic CO concentrations, low-dose CO acts as a signaling molecule and can exert many complex cytoprotective effects. Therefore, the effects of low-dose CO are being investigated and developed as a new treatment method for use in various disease processes. However, these studies are mostly in vivo and in vitro studies and clinical studies have not reached a sufficient number. In this study, the effect of subclinical COHB levels on biomarkers such as TAS, TOS, HIF-1α will be evaluated.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2, 2024
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 3, 2022
Actual (reported)December 22, 2022
Actual (reported)January 2, 2023
Actual (reported)June 2, 2024
Actual (reported)June 2, 2024
Actual (reported)Cohb
carboxyhemoglobin
t1: first hour of surgery
tas
total antioxidant status
t1: first hour of surgery
tos
total oxidant status
t1: first hour of surgery
hif-1α
hypoxia inducible factor 1α
t1: first hour of surgery
In the Group (DA), the standard consisting of electrocardiogram(ECG), peripheral oxygen saturation (Spo2), and non-invasive blood pressure will be monitored.Prior to induction, the first blood sample (To) will be taken for analysis. After induction of anesthesia with propofol and rocuronium, he will be intubated.Anesthesia will be maintained with desflurane (MAC:1), oxygen (50%), air (50%). After a high flow phase of 4 l/min for 10 min, the fresh gas flow will be reduced to 0.6 L/min and fentanyl,rocuronium will be administered intermittently. Patients will be ventilated with a ventilator at a constant tidal volume (kg x 6 mL) and respiratory rate (12/min). At the 1st hour of low flow anesthesia maintenance, a second blood sample (T1) will be taken for analysis. Patients will be awakened at the end of the case. After the recovery room, it will be transferred to the relevant service. A third blood sample (T2) will be taken at the postoperative 24th hour in the service for analysis.
In the Group (NA),the standard consisting of electrocardiogram(ECG), peripheral oxygen saturation (Spo2),non-invasive blood pressure will be monitored.Prior to induction, the first blood sample (To) will be taken for analysis.After induction of anesthesia with propofol and rocuronium, patients will be intubated. Anesthesia will be maintained with desflurane (MAC:1), oxygen (50%), air (50%). After a high flow phase of 4 l/min for 10 min, the fresh gas flow will be reduced to 2.0 L/min and fentanyl, rocuronium will be administered intermittently. Patients will be ventilated with a ventilator at a constant tidal volume (kg x 6 mL) and respiratory rate (12/min). A second blood sample (T1) will be taken for analysis at the 1st hour of normal flow anesthesia maintenance. Patients will be awakened at the end of the case. After the recovery room, it will be transferred to the relevant service. A third blood sample (T2) will be taken at the postoperative 24th hour in the service for analysis
Changes in blood carboxyhemoglobin levels as a result of exposure to rebreathing during low-flow anaesthesia.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients aged 18-80, without systemic disease, non-smoker, who will undergo elective surgery under general anesthesia
Ataturk University
Erzurum, Turkey (Türkiye)
Bauer I, Pannen BH. Bench-to-bedside review: Carbon monoxide--from mitochondrial poisoning to therapeutic use. Crit Care. 2009;13(4):220. doi: 10.1186/cc7887. Epub 2009 Aug 14.
Lee SJ, Ryter SW, Xu JF, Nakahira K, Kim HP, Choi AM, Kim YS. Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. Am J Respir Cell Mol Biol. 2011 Oct;45(4):867-73. doi: 10.1165/rcmb.2010-0352OC. Epub 2011 Mar 25.
VEYSEL KOKSAL, PROF ASS
same
130 participants (actual enrollment reported by the registry).
First Submitted
December 3, 2022
First Posted
December 22, 2022
Study Start
January 2, 2023
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
June 2, 2024
Actual (reported)Study Completion
June 2, 2024
Actual (reported)Last Updated
June 17, 2024
Record last verified: 2024-06
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Source: ClinicalTrials.gov.
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