Walk It Off! the Influence of Physical Activity Level on the Recovery from Damaging Resistance Exercise

NCT06810271 | Active Not Recruiting

• 2 other identifiers: WIO00045256
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.

Conditions

Exercise Induced Muscle Damage; Physical Activity; Inflammation; Exercise Recovery; Skeletal Muscle Damage; Young Adults; Delayed Onset Muscle Soreness (DOMS)

Keywords

Resistance exercise; Exercise induced muscle damage; Ultrasound; Subjective pain; Physical activity

Outcome Measures

Primary Outcomes (1)

• Change in maximal muscle strength between physical activity levels

  Maximal voluntary isometric and isokinetic contraction assessed by peak torque via computerized dynamometer.

  Daily assessment (every 24 hours) across 96 hours post-exercise

Secondary Outcomes (2)

• Delayed onset muscle soreness (DOMS)

  Daily assessments (every 24 hours) across 96 hours post-exercise

• Change in muscle and fascial connective tissue thickness

  Daily assessment (every 24 hours) across 96 hours post-exercise

Study Arms (2)

High Activity

EXPERIMENTAL

Requires completion of greater than 10,000 steps per day

Behavioral: Eccentric resistance exercise

Moderate Activity

EXPERIMENTAL

Requires completion of less than 5,000 steps per day

Behavioral: Eccentric resistance exercise

Interventions

Eccentric resistance exercise BEHAVIORAL

150 maximal, unilateral eccentric contractions of the quadriceps muscles on a computerized dynamometer.

High Activity; Moderate Activity

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Healthy, recreationally active male and female participants (i.e., weekly MET-minutes \> 3000 assessed by International Physical Activity Questionnaire).
• Not having a health condition that would compromise their ability to safely participate in the strenuous physical activity involved in our study screened for by the get active questionnaire.
• Between 18 and 35 years old.
• Body mass index (BMI) between 18.5-30
• Self-reported not having engaged in resistance exercise and/or lower body plyometrics for at least 3 months prior to the study.
• Willing to abide by the compliance rules of this study.
• Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).

You may not qualify if:

• Inability to adhere to any of the compliance rules judged by the principal investigator or medical doctor.
• Self-reported regular tobacco use.
• Regular use of non-steroidal anti-inflammatory drugs (e.g., Advil)
• Use of oral contraceptives (female participants).

Sponsors & Collaborators

• University of Toronto: lead

Study Sites (1)

Goldring Center for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Location

MeSH Terms

Conditions

Motor Activity; Inflammation

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Study includes a behavioural intervention of high and moderate physical activity, modelled by step counts, as a "treatment", or method to improve recovery from the exercise-induced muscle damage intervention occurring in both high and moderate activity phases.

Study Record Dates

• First Submitted: January 24, 2025
• First Posted: February 5, 2025
• Study Start: January 24, 2025
• Primary Completion: January 1, 2026
• Study Completion: May 1, 2026
• Last Updated: February 5, 2025

Record last verified: 2025-01

Locations

CA (1)