Analysis of Single Respiratory Viral Infections Versus Co-infections: Prevalence and ICU Needs in Hospitalized Adults

NCT06779175 | Completed

• 1 other identifier: GOKAEK-2024/05.17 2024/140
• Study Type: observational
• Target: 231
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of our study is to investigate the prevalence of viral respiratory infections in inpatients following the end of the pandemic. Additionally, the prevalence of patients co-infected with multiple viruses simultaneously will be assessed. In the secondary part of the study, the development of respiratory tract infections, the need for intensive care, and mortality rates within seven days will also be evaluated, and risk factors for patients with a more severe clinical course will be statistically calculated.

Conditions

Respiratory Tract Infections; Virus Diseases; Coinfection

Outcome Measures

Primary Outcomes (1)

• Prevalence of Single and Co-infections in Respiratory Viral Infections

  Objective: To determine the prevalence of single respiratory viral infections and co-infections in hospitalized adults after COVID-19 pandemic. Assessment Tool: Hospital automation system for patient demographic and clinical data, and multiplex PCR testing for pathogen detection. Unit of Measure: Percentage of patients with each viral infections

  On 12 January 2025, the retrospective analysis of patients was started. The study is expected to be completed within 3 months.

Secondary Outcomes (1)

• Risk Factors and Rates of ICU Admission and Mortality in Respiratory Viral Infections

  On 12 January 2025, the retrospective analysis of patients was started. The study is expected to be completed within 3 months.

Study Arms (2)

Viral respiratory infection

Symptomatic and verified viral upper respiratory tract infections in hospitalized patients

Viral respiratory co-infection

Inpatients who are symptomatic and infected with more than one respiratory virus simultaneously

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population includes patients over 18 years of age who are hospitalized, have symptoms of respiratory tract infection, and have a positive result for a respiratory tract virus detected by PCR. Patients with SARS-CoV-2 PCR-positive symptoms who require antiviral treatment will be classified as cases of COVID-19.

You may qualify if:

• Patients over 18 years of age
• Patients admitted to our clinic or consulted to infectious diseases from other inpatient services.
• Patients diagnosed with upper or lower respiratory tract infections due to viral agents

You may not qualify if:

• Patients infected with bacterial agents will not be included in the study.
• Patients admitted from the outpatient clinic were not included in the study plan.

Sponsors & Collaborators

• Kocaeli University: lead

Study Sites (1)

Kocaeli University

Kocaeli, Turkey (Türkiye)

Location

Related Publications (3)

• Shan N, Zheng Z. A Case of Nosocomial Coinfection of SARS-CoV-2 and Influenza A Virus in a Hospitalized Patient with Acute Myocardial Infarction. Clin Lab. 2024 Jan 1;70(1). doi: 10.7754/Clin.Lab.2023.230735.

  PMID: 38213216 BACKGROUND

• Kanji JN, Zelyas N, Pabbaraju K, Granger D, Wong A, Murphy SA, Buss E, MacDonald C, Berenger BM, Diggle MA, Marshall NC, Conly JM, Tipples G. Respiratory virus coinfections with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) continue to be rare one year into the coronavirus disease 2019 (COVID-19) pandemic in Alberta, Canada (June 2020-May 2021). Infect Control Hosp Epidemiol. 2023 May;44(5):805-808. doi: 10.1017/ice.2021.495. Epub 2021 Dec 6.

  PMID: 34866560 BACKGROUND

• Mochan E, Sego TJ. Mathematical Modeling of the Lethal Synergism of Coinfecting Pathogens in Respiratory Viral Infections: A Review. Microorganisms. 2023 Dec 13;11(12):2974. doi: 10.3390/microorganisms11122974.

  PMID: 38138118 BACKGROUND

MeSH Terms

Conditions

Respiratory Tract Infections; Virus Diseases; Coinfection

Condition Hierarchy (Ancestors)

Infections; Respiratory Tract Diseases

Study Officials

• Özlem Güler, Assist. Prof

  Kocaeli University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor M.D.

Study Record Dates

• First Submitted: January 12, 2025
• First Posted: January 16, 2025
• Study Start: January 12, 2025
• Primary Completion: July 7, 2025
• Study Completion: July 7, 2025
• Last Updated: July 8, 2025

Record last verified: 2025-07

Locations

TU (1)