Molecular Characterization of Moraxella Catarrhalis From Pneumonic Children at Pediatric Assiut University Hospital

NCT06357507 | Not Yet Recruiting DMC

• 1 other identifier: hayam hamdy
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

moraxella catarrhalis is responsible for respiratory tract infection in children and adults with streptococcus pneumonia and haemophilus influenza.Moraxella catarrhalis is gram negative diplococci, non-motile and non spore bearing bacteria. Until, 1995 it was considered as a non pathogenic respiratory tract flora.This bacteria is an important pathogen and a common cause of both upper and lower respiratory tract infections, pneumonia, sinusitis and conjunctivitis in infants, children and in elderly patients. In adults, M. catarrhalis also causes chronic obstructive pulmonary disease (COPD) and pneumonia. However, it is associated with a number of respiratory infections affecting both children and adults, including laryngitis, bronchitis and pneumonia .

Conditions

Respiratory Tract Infections

Outcome Measures

Primary Outcomes (1)

• isolation of moraxella catarrhalis

  isolation of organism on muller hinton agar

  3 years

Secondary Outcomes (2)

• detection of virulence genes of moraxella catarrhalis

  3 years

• detetion of antibiotic resistance

  3years

Eligibility Criteria

• Age: 1 Month+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

children with respiratory tract infection

You may qualify if:

• all children with bacterial pneumonia

You may not qualify if:

• viral pneumonia , tuberculosis and immunocompromised

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008 Nov 27;359(22):2355-65. doi: 10.1056/NEJMra0800353. No abstract available.

  PMID: 19038881 BACKGROUND

• Blakeway LV, Tan A, Peak IRA, Seib KL. Virulence determinants of Moraxella catarrhalis: distribution and considerations for vaccine development. Microbiology (Reading). 2017 Oct;163(10):1371-1384. doi: 10.1099/mic.0.000523. Epub 2017 Sep 12.

  PMID: 28893369 BACKGROUND

• Bernhard S, Spaniol V, Aebi C. Molecular pathogenesis of infections caused by Moraxella catarrhalis in children. Swiss Med Wkly. 2012 Oct 29;142:w13694. doi: 10.4414/smw.2012.13694. eCollection 2012.

  PMID: 23136074 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

sputum samples for DNA extraction and PCR

MeSH Terms

Conditions

Respiratory Tract Infections

Condition Hierarchy (Ancestors)

Infections; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: faculty of medicine meical microbiology and immunology

Study Record Dates

• First Submitted: April 5, 2024
• First Posted: April 10, 2024
• Study Start: December 1, 2024
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 20, 2027
• Last Updated: April 16, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share