Viral Infections in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
VICE
Impact of Viral Infections in Patients With Chronic Obstructive Pulmonary Diseases: Virological Work-up During Exacerbations and 1-year Follow-up
1 other identifier
observational
86
1 country
1
Brief Summary
The objectives of the study are
- to determine the prevalence of respiratory virus infections in COPD patients, during and outside acute exacerbation
- to explore the impact of these viral infections on the outcome of these patients
- to explore the association between blood procalcitonin levels and viral infections in this population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2007
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 16, 2007
CompletedFirst Posted
Study publicly available on registry
March 19, 2007
CompletedStudy Start
First participant enrolled
May 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2009
CompletedNovember 4, 2010
February 1, 2009
2.3 years
March 16, 2007
November 3, 2010
Conditions
Keywords
Eligibility Criteria
Patients with COPD admitted with acute exacerbation
You may qualify if:
- All consecutive patients known or suspected for moderate to very severe COPD and admitted in the emergency center for an acute exacerbation of their COPD
- Age above 18 years
- We plan to include 100 patients with a complete work-up and follow-up
- Written informed consent will be obtained from every participant
You may not qualify if:
- Patients requiring oro-tracheal intubation
- Patients unable to give their informed consent due to their clinical condition
- Other obvious cause of dyspnea (pulmonary embolism, acute pulmonary edema, lobar pneumonia)
- Patients suffering from bronchiectasis, asthma, pulmonary fibrosis and mineral dust pneumoconiosis
- Patients with a history of active tuberculosis
- Patients with a history of ischemic cerebral stroke and subsequent deglutition dysfunction
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospital, Genevalead
- Ligue Pulmonaire Genevoisecollaborator
Study Sites (1)
Geneva University Hospital
Geneva, Canton of Geneva, 1211, Switzerland
Related Publications (1)
Kherad O, Kaiser L, Bridevaux PO, Sarasin F, Thomas Y, Janssens JP, Rutschmann OT. Upper-respiratory viral infection, biomarkers, and COPD exacerbations. Chest. 2010 Oct;138(4):896-904. doi: 10.1378/chest.09-2225. Epub 2010 Apr 30.
PMID: 20435659DERIVED
Biospecimen
Naso-pharyngeal swaps
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Olivier T Rutschmann, MD, MPH
University Hospital, Geneva
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 16, 2007
First Posted
March 19, 2007
Study Start
May 1, 2007
Primary Completion
September 1, 2009
Study Completion
September 1, 2009
Last Updated
November 4, 2010
Record last verified: 2009-02