Food Orders on Blood Glucose and Fuel Use At Rest

NCT06763562 | Recruiting

• 1 other identifier: 24-163
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Consuming a carbohydrate-rich food as the final food in a meal, as compared to the first food in a meal, has been shown to reduce blood glucose levels after eating in both diabetes patients and in healthy controls. However, gaps remain in the literature in this area of research, and currently little is known about how substrate (fuel) use is impacted by altering food order. In addition, most studies to date have used a mix of meat and plant foods, while little research has focused exclusively on vegetarian foods. This randomized experiment will examine how altering the order of foods eaten in a vegetarian meal impacts blood glucose and fuel utilization at rest.

Conditions

Glucose Metabolism Disorders; Hunger; Fat Burn

Outcome Measures

Primary Outcomes (1)

• Respiratory exchange ratio

  Ratio of carbon dioxide production and oxygen consumption for determination of fuel use

  90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)

Secondary Outcomes (4)

• Fat use

  90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)

• Carbohydrate use

  90 minutes (baseline/premeal and at 30, 60, and 90 minutes postmeal)

• Blood glucose

  90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)

• Hunger-satiety perceptions

  90 minutes (baseline/premeal and 30, 60, and 90 minutes postmeal)

Study Arms (2)

Carbohydrate-first meal

EXPERIMENTAL

Other: Carbohydrate-first meal

Carbohydrate-last meal

EXPERIMENTAL

Other: Carbohydrate-last meal

Interventions

Carbohydrate-first meal OTHER

Rice eaten first (150 grams), followed by edamame (150 grams) and butter (10 grams)

Carbohydrate-first meal

Carbohydrate-last meal OTHER

Edamame (150 grams) and butter (10 grams) eaten first, followed by rice (150 grams)

Carbohydrate-last meal

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years old
• Free from any allergy or condition that precluding consumption of edamame, butter, and rice
• Not currently pregnant
• Free of any medical conditions requiring the use of insulin
• Have no history of bariatric surgery
• Have no implanted electrical devices such as a pacemaker

You may not qualify if:

• Younger than 18 and older than 70 years old
• Having an allergy or condition that precludes consumption of edamame, butter, and rice
• Currently pregnant
• Any medical conditions requiring the use of insulin
• A history of bariatric surgery
• Having an implanted electrical device such as a pacemaker

Sponsors & Collaborators

• Old Dominion University: lead

Study Sites (1)

Old Dominion University Human Performance Laboratory

Norfolk, Virginia, 23529, United States

RECRUITING

MeSH Terms

Conditions

Glucose Metabolism Disorders

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Patrick Wilson, PhD

CONTACT

757-683-4783; pbwilson@odu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Exercise Science

Study Record Dates

• First Submitted: January 2, 2025
• First Posted: January 8, 2025
• Study Start: January 5, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: February 19, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share
• Time Frame: Data will become available once the associated article is officially published. The data will be made available indefinitely.

Locations

US (1)