Ordered Eating and Acute Exercise

NCT06242015 | Completed

• 1 other identifier: 24-003
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise. Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

Conditions

Glucose Metabolism Disorders; Hunger

Keywords

Exercise; Glucose; Fat metabolism; Hunger

Outcome Measures

Primary Outcomes (1)

• Postprandial glucose

  Blood glucose will be measured with fingerstick samples and a portable glucometer

  2 hours (premeal and 30, 60, 90, and 120 minutes after eating)

Secondary Outcomes (4)

• Carbohydrate use

  100 minutes (premeal and continuously for 90 minutes after eating)

• Fat use

  100 minutes (premeal and continuously for 90 minutes after eating)

• Hunger-satiety perceptions

  2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)

• Rating of perceived exertion

  30 minutes (at 8, 18, 28 minutes of exercise)

Study Arms (2)

Carbohydrate-first meal

EXPERIMENTAL

Other: Carbohydrate-first meal

Carbohydrate-last meal

EXPERIMENTAL

Other: Carbohydrate-last meal

Interventions

Carbohydrate-first meal OTHER

Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)

Carbohydrate-first meal

Carbohydrate-last meal OTHER

Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)

Carbohydrate-last meal

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
• Ability to perform moderate-to-high intensity running for at least 30 minutes

You may not qualify if:

• Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
• Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
• Currently pregnant
• Implanted electrical devices such as a pacemaker.

Sponsors & Collaborators

• Old Dominion University: lead

Study Sites (1)

ODU Human Performance Laboratory

Norfolk, Virginia, 23529, United States

Location

MeSH Terms

Conditions

Glucose Metabolism Disorders; Motor Activity

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Study Officials

• Patrick Wilson

  Old Dominion University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Exercise Science

Study Record Dates

• First Submitted: January 28, 2024
• First Posted: February 5, 2024
• Study Start: February 6, 2024
• Primary Completion: July 30, 2024
• Study Completion: July 30, 2024
• Last Updated: August 1, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Time Frame: The data will be made available upon the study's publication and will remain available for at least 5 years
• Access Criteria: Researchers with a justified reason for wanting access to the data

Locations

US (1)