Hunger Perception and Weight-Related Outcomes Following Use of a Leptin-Supporting Dietary Supplement

NCT07442864 | Recruiting

• 1 other identifier: 43484
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates changes in hunger perception and body composition-related measures following daily use of a commercially available dietary supplement formulated to support leptin-related metabolic signaling. Adult participants will self-administer the supplement for 12 weeks and complete periodic self-reported assessments related to appetite, hunger, and weight-related outcomes. Participants serve as their own control, with comparisons made between baseline and follow-up measurements. The study is designed to generate preliminary, real-world evidence regarding supplement use in a general wellness context.

Conditions

Hunger; Weight Change

Keywords

Hunger; Leptin; Weight Management

Outcome Measures

Primary Outcomes (1)

• Change in Hunger Perception

  Change from baseline in self-reported hunger perception as measured by a standardized hunger perception questionnaire.

  Baseline and Week 12

Secondary Outcomes (2)

• Change in Body Weight

  Baseline and Week 12

• After-Meal Hunger and Fatigue Perception

  Baseline, Week 4, Week 8, and Week 12

Study Arms (1)

Single Arm longitudinal where participants act as their own control

EXPERIMENTAL

Single Arm longitudinal where participants act as their own control

Dietary Supplement: Leptin Balance Formula

Interventions

Leptin Balance Formula DIETARY_SUPPLEMENT

Participants will self-administer the Leptin Balance Formula daily for 12 weeks according to product labeling. The supplement is commercially available and includes African mango seed extract, chromium picolinate, Ceylon cinnamon, and alpha lipoic acid.

Single Arm longitudinal where participants act as their own control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older
• Willing to pay for study supplies and able to take the dietary supplement daily for 12 weeks
• Willing to complete electronic questionnaires and self-reported measurements
• Able to provide informed consent

You may not qualify if:

• Pregnant or breastfeeding individuals
• Known allergy or sensitivity to any supplement ingredients
• Use of medications or supplements that could interfere with appetite or weight without medical clearance
• Any medical condition that would make participation unsafe, as determined by the participant

Sponsors & Collaborators

• Efforia, Inc: lead

Study Sites (1)

Efforia

New York, New York, 10003, United States

RECRUITING

Related Links

• Study recruitment landing page

MeSH Terms

Conditions

Body Weight Changes

Condition Hierarchy (Ancestors)

Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Matthew Amsden

CONTACT

646-679-2479; help@efforia.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 24, 2026
• First Posted: March 2, 2026
• Study Start: September 10, 2025
• Primary Completion (Estimated): September 10, 2026
• Study Completion (Estimated): September 10, 2026
• Last Updated: March 2, 2026

Record last verified: 2025-09

Locations

US (1)