Evaluation of Remnant Cholesterol Levels and Monocyte-to-HDL-cholesterol Ratio As Predictors of Coronary Artery Disease Severity in Patients with Acute Coronary Syndrome

NCT06757777 | Not Yet Recruiting

• 1 other identifier: Monocyte to HDL Cholest. Ratio
• Study Type: observational
• Target: 54
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Evaluation of serum level of remnant cholesterol and monocyte/HDL ratio as predictors of severity of coronary artery disease in patients with acute coronary syndrome.
2. 2.Evaluate predictive value of remnant cholesterol serum level and monocyte/HDL ratio to detect in-hospital worse clinical outcomes and 45 days major adverse cardiac events (MACE) after acute coronary syndrome.

Conditions

Acute Coronary Syndrome; ACS (acute Coronary Syndrome); Monocyte to HDL Cholesterol Ratio; STEMI; Non STEMI

Keywords

Acs; Acute coronary syndrome; STEMI; NON STEMI; Monocyte/HDL Ratio

Outcome Measures

Primary Outcomes (1)

• Evaluation of serum level of remnant cholesterol and monocyte/HDL ratio as predictors of severity of coronary artery disease in patients with acute coronary syndrome.

  Baseline

Secondary Outcomes (1)

• Evaluate predictive value of remnant cholesterol serum level and monocyte/HDL ratio to detect in-hospital worse clinical outcomes and 45 days major adverse cardiac events (MACE) after acute coronary syndrome.

  Baseline

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute coronary syndrome presented to ER of Assiut university hospital scheduled for primary PCI and able to provide informed consent

You may qualify if:

• Patients with acute coronary syndrome presented to ER of Assiut university hospital scheduled for primary PCI and able to provide informed consent.

You may not qualify if:

• Patients on previous statin therapy.
• Patients with severe renal dysfunction (creatinine clearance \<30 mL/min) or other contraindications to PCI.
• Patients with missed data or who couldn't be followed up

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Wadstrom BN, Wulff AB, Pedersen KM, Jensen GB, Nordestgaard BG. Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study. Eur Heart J. 2022 Sep 7;43(34):3258-3269. doi: 10.1093/eurheartj/ehab705.

  PMID: 34661640 BACKGROUND

• Zegre-Hemsey JK, Asafu-Adjei J, Fernandez A, Brice J. Characteristics of Prehospital Electrocardiogram Use in North Carolina Using a Novel Linkage of Emergency Medical Services and Emergency Department Data. Prehosp Emerg Care. 2019 Nov-Dec;23(6):772-779. doi: 10.1080/10903127.2019.1597230. Epub 2019 Apr 17.

  PMID: 30885071 BACKGROUND

MeSH Terms

Conditions

Acute Coronary Syndrome; ST Elevation Myocardial Infarction; Non-ST Elevated Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Myocardial Infarction; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Isaac A Ghaly, Resident

  Assiut University

  PRINCIPAL INVESTIGATOR

• Hanan A Mahmoud, Lecturer

  Assiut University

  STUDY DIRECTOR

• Khaled A Mohamed, Lecturer

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Isaac A Ghaly, Resident

CONTACT

+201201979010; ishaq.16287235@med.aun.edu.eg

Hanan A Mahmoud, Lecturer

CONTACT

01065735355; drhanan_abuelrus@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: December 26, 2024
• First Posted: January 3, 2025
• Study Start: February 8, 2025
• Primary Completion: February 8, 2026
• Study Completion: March 8, 2026
• Last Updated: February 11, 2025

Record last verified: 2024-12