Relationship Between Inflammatory (Hs-CRP, Neutrophil-to-Lymphocyte Ratio) and Cardiac (Troponin) Biomarkers, and Cardiac Dysfunction in Acute Coronary Syndrome.

NCT07551102 | Not Yet Recruiting

• 1 other identifier: cardiac dysfunction ACS
• Study Type: observational
• Target: 144
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute Coronary Syndrome (ACS) remains a leading cause of morbidity and mortality worldwide, accounting for a significant proportion of cardiovascular-related deaths. Early diagnosis and accurate risk stratification are crucial for improving clinical outcomes and guiding therapeutic decisions. Cardiac troponins (I and T) are highly sensitive and specific biomarkers of myocardial injury and represent the gold standard for the diagnosis of ACS (1). In recent years, inflammation has been recognized as a key contributor to the pathophysiology of atherosclerosis and plaque instability. Inflammatory biomarkers such as high-sensitivity C-reactive protein (hs-CRP) and the neutrophil-to-lymphocyte ratio (NLR) have gained attention as predictors of adverse cardiovascular outcomes. Elevated hs-CRP levels are associated with increased risk of myocardial infarction and poor prognosis (2), while NLR reflects the balance between inflammatory activation and immune regulation and has been linked to severity of coronary artery disease and mortality in ACS patients (3). Echocardiography remains a cornerstone in the assessment of cardiac function, providing essential information about left ventricular ejection fraction (LVEF) and regional wall motion abnormalities (RWMA). More recently, speckle tracking echocardiography (STE) has emerged as a sensitive tool for detecting subclinical myocardial dysfunction through parameters such as global longitudinal strain (GLS), even before a reduction in LVEF becomes apparent (4,5). Despite the established individual roles of cardiac and inflammatory biomarkers, limited data are available regarding their combined effect on cardiac function, particularly when integrated with advanced echocardiographic techniques. Therefore, this study aims to evaluate the relationship between inflammatory biomarkers (hs-CRP, NLR), cardiac biomarker (troponin), and echocardiographic findings in patients with ACS to enhance early risk stratification and improve clinical decision-making.

Conditions

Acute Coronary Syndrome

Outcome Measures

Primary Outcomes (1)

• correlation between troponin with left ventricular systolic dysfunction

  elevation of cardiac marker (troponin) with left ventricular systolic dysfunction (LVEF, GLS).

  baseline

Study Arms (1)

study group

Patients diagnosed with Acute Coronary Syndrome (STEMI, NSTEMI, or unstable angina)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with Acute Coronary Syndrome (STEMI, NSTEMI, or unstable angina)

You may qualify if:

• Adult patients (≥18 years)
• Patients diagnosed with Acute Coronary Syndrome (STEMI, NSTEMI, or unstable angina)
• Presentation within 24 hours of symptoms onset
• Informed consent

You may not qualify if:

• Chronic inflammatory diseases
• Active infection
• Malignancy
• Severe hepatic or renal failure
• Autoimmune diseases
• Patients with known cardiomyopathy or chronic reduced ejection fraction
• Patients with ACS treated with thrombolysis

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: residant doctor at Assiut university hospital

Study Record Dates

• First Submitted: April 19, 2026
• First Posted: April 24, 2026
• Study Start: May 1, 2026
• Primary Completion: May 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 24, 2026

Record last verified: 2026-04