NCT06749106|Recruiting
Plaque Imaging in Routine Care to Detect Intraplaque Hemorrhage
PARADE
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PARADE
Sponsor study identifier
observational
300
1 country
1
Study Start
January 16, 2025
Actual (reported)Primary Completion
December 31, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The aim of this study is to investigate the association between intraplaque hemorrhage (IPH) detected by non-contrast magnetic resonance imaging (MRI) of the carotid artery in routine clinical practice and ipsilateral acute ischemic events. The investigators' overarching aim is to determine whether this sequence aids the diagnostic work-up of stroke patients. For this purpose, the investigators set up a prospective single-center longitudinal observational study with one year follow-up. In addition, this study will analyze retrospectively obtained data collected through clinical routine.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 19, 2024
Actual (reported)December 27, 2024
Actual (reported)January 16, 2025
Actual (reported)December 31, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
intraplaque hemorrhage (IPH)
presence of IPH as detected on routine non-contrast MRI
baseline
recurrent ischemic stroke or TIA
3 months, 12 months
Plaque-RADS
baseline
Barthel Scale
baseline, 3 months, 12 months
modified Rankin Scale (mRS)
baseline, 3 months, 12 months
National Institutes of Health Stroke Scale (NIHSS)
baseline
Patients with acute ischemic stroke, who received non-contrast carotid MRI for routine diagnostic work-up
Patients with acute ischemic stroke, who received non-contrast carotid MRI for routine diagnostic work-up, will be asked whether they are willing to participate in a prospective, longitudinal study with telephone follow-up to assess recurrent ischemic stroke or TIA. Patients who are unable to provide informed consent for themselves, children and adolescents will not be recruited. Detailed eligibility criteria for the prospective longitudinal study are provided above. In addition, this study will analyse retrospectively obtained data collected through clinical routine: These analyses will be done on all patients who received non-contrast carotid MRI for routine diagnostic work-up over the last years. This approach allows to estimate the prevalence of IPH in an unselected patient population.
Institute for Stroke and Dementia Research
Munich, 81377, Germany
Anna Kopczak, MD
Institute for Stroke and Dementia Research
Anna Kopczak, MD
CONTACT
First Submitted
December 19, 2024
First Posted
December 27, 2024
Study Start
January 16, 2025
Actual (reported)Primary Completion
December 31, 2028
EstimatedNetworked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
January 24, 2025
Record last verified: 2025-01
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