Improving Low ASPECTS Stroke Thrombectomy
I-LAST
Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy
1 other identifier
observational
500
2 countries
8
Brief Summary
Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome. Advanced imaging biomarkers will be tested and validated aiming to improve treatment selection and outcome prediction of patients presenting with extensive baseline infarction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2023
Longer than P75 for all trials
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 13, 2021
CompletedFirst Posted
Study publicly available on registry
April 28, 2021
CompletedStudy Start
First participant enrolled
May 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
January 1, 2028
May 24, 2023
May 1, 2023
3.7 years
April 13, 2021
May 23, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
modified ranking scale on day (mRs) day 90
mRs: modified ranking scale; the scale is a commonly used measurement for the degree of disability or dependence in the daily activities of people who have suffered a stroke; scale range 0-6, with 0 - No symptoms. 1 - No significant disability. Able to carry out all usual activities, despite some symptoms. 2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3 - Moderate disability. Requires some help, but able to walk unassisted. 4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6 - Dead. publication: van Swieten J, Koudstaal P, Visser M, Schouten H, et al. (1988). "Interobserver agreement for the assessment of handicap in stroke patients". Stroke. 19 (5): 604-607. doi:10.1161/01.str.19.5.604.
90 days
Secondary Outcomes (2)
Ischemic lesion water uptake on admission
0-24 hours after symptom onset
Ischemic lesion water uptake on follow-up imaging
24-48 hours after admission
Study Arms (2)
Stroke Patients with an ASPECTS of 0-5 on baseline neuroimaging undergoing thrombectomy
acute stroke patients treated with endovascular treatment combined with thrombolysis or without previous thrombolysis Intervention.
Stroke Patients with an ASPECTS of 0-5 on baseline neuroimaging not undergoing thrombectomy
acute stroke patients treated with or without thrombolysis
Interventions
telephone call on day 90 to assess the primary outcome (mRs 90)
Retrospective quantification of lesion water uptake by CT densitometry in admission and follow-up imaging
Eligibility Criteria
All acute stroke patients with the clinical diagnosis of acute ischemic stroke with a ASPECTS 0f 0-5 on baseline imaging; Age \>18 years
You may qualify if:
- Clinical diagnosis of acute ischemic stroke
- ASPECTS of 0-5
- Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms
- Age \>18 years
- Ethic approval in process
You may not qualify if:
- none
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Universitätsklinikum Hamburg-Eppendorflead
- University of Kaiserslauterncollaborator
- University Hospital Muenstercollaborator
- University of Rostockcollaborator
- University Hospital, Basel, Switzerlandcollaborator
- Charite University, Berlin, Germanycollaborator
- Klinikum Bremen-Mitte, gGmbHcollaborator
Study Sites (8)
Charite University Berlin
Berlin, Germany
Hospital Bremen-Mitte
Bremen, Germany
University Medical Center Hamburg-Eppendorf
Hamburg, 20251, Germany
Westpfalzklinikum
Kaiserslautern, Germany
University Hospital Marburg
Marburg, Germany
University Münster
Münster, Germany
University Rostock
Rostock, Germany
University Basel
Basel, Switzerland
Related Publications (1)
Broocks G, Meyer L, Elsayed S, McDonough R, Bechstein M, Faizy TD, Sporns P, Schon G, Minnerup J, Kniep HC, Hanning U, Barow E, Schramm P, Langner S, Nawabi J, Papanagiotou P, Wintermark M, Lansberg MG, Albers GW, Heit JJ, Fiehler J, Kemmling A; I-LAST Investigators. Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions: Results From the I-LAST Study. Neurology. 2023 Feb 28;100(9):e954-e963. doi: 10.1212/WNL.0000000000201601. Epub 2022 Nov 22.
PMID: 36414425DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 90 Days
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor, Principal Investigator
Study Record Dates
First Submitted
April 13, 2021
First Posted
April 28, 2021
Study Start
May 1, 2023
Primary Completion (Estimated)
January 1, 2027
Study Completion (Estimated)
January 1, 2028
Last Updated
May 24, 2023
Record last verified: 2023-05