Prognostic Markers of Post-Stroke Depression (PROMoSD)
PROMoSD
1 other identifier
observational
105
1 country
1
Brief Summary
Single-center prospective observational study investigating the association of brainstem raphe hypoechogenicity detected by transcranial sonography and post-stroke depression three months after an acute ischemic stroke.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2021
CompletedFirst Submitted
Initial submission to the registry
October 11, 2022
CompletedFirst Posted
Study publicly available on registry
October 14, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2023
CompletedOctober 17, 2022
October 1, 2022
1.8 years
October 11, 2022
October 13, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Post-stroke depression
PSD diagnosis was defined according to the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V criteria) or by any new medication for anti-depressive indication during follow-up
3 months
Secondary Outcomes (1)
Severity of depressive symptoms
3 months
Study Arms (2)
BRH+
Acute ischemic stroke patients with brainstem raphe hypoechogenicity.
BRH-
Acute ischemic stroke patients without brainstem raphe hypoechogenicity.
Interventions
Transcranial sonography examination to determine the brainstem raphe echogenicity.
Eligibility Criteria
Patients who present with an acute ischemic stroke to the emergency department with the onset of symptoms within the past 14 days.
You may qualify if:
- Acute ischemic stroke with the onset of symptoms within the past 14 days
- Diagnosis of AIS is confirmed by brain imaging, either computer tomography or magnetic resonance imaging
You may not qualify if:
- Insufficient transtemporal bone window for transcranial sonography examination
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
St. Josef-Hospital Bochum
Bochum, North Rhine-Westphalia, 44791, Germany
Related Publications (1)
Richter D, Ebert A, Mazul-Wach L, Ruland Q, Charles-James J, Gold R, Tsivgoulis G, Juckel G, Krogias C. Prognostic markers of post-stroke depression (PROMoSD): study protocol of a prospective single-center observational study on raphe hypoechogenicity as a predictor of post-stroke depression. Neurol Res Pract. 2022 Dec 9;4(1):59. doi: 10.1186/s42466-022-00225-5.
PMID: 36494874DERIVED
Biospecimen
Serum blood
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christos Krogias, Prof.
St. Josef-Hospital Bochum, Ruhr-University Bochum
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr.
Study Record Dates
First Submitted
October 11, 2022
First Posted
October 14, 2022
Study Start
January 1, 2021
Primary Completion
November 1, 2022
Study Completion
March 1, 2023
Last Updated
October 17, 2022
Record last verified: 2022-10