Protein, Sarcopenic Obesity, and COPD

NCT06735573 | Enrolling By Invitation

• 2 other identifiers: T BaabbadUniversity of Aberdeen
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Both sarcopenic obesity and chronic obstructive pulmonary diseases (COPD) are common conditions that mainly affect middle-aged and older adults. Previous research has shown that increased dietary intake of total and plant-based protein is associated with a lower risk of sarcopenic obesity, using data from the EPIC Norfolk study. Furthermore, a systematic review and meta-analysis showed that having sarcopenic obesity was associated with significantly impaired lung function outcomes. Other research has shown that increased intake of dietary protein leads to a better treatment outcome for respiratory diseases. The aim of this pilot observational study is to investigate, in more detail, the relationship between the quantity and source of dietary protein intake, the prevalence of sarcopenic obesity, and lung function, in a small cohort of older female participants with COPD. The study will also consider the role of inflammation in relation to sarcopenic obesity and lung function outcomes. This study will help to improve the understanding of the relationship between sarcopenic obesity and lung function outcomes, and how dietary protein intake and inflammation can affect this relationship and each of the outcomes.

Conditions

Sarcopenic Obesity; Chronic Obstructive Pulmonary Diseases

Outcome Measures

Primary Outcomes (1)

• Association between dietary protein and the prevalence of sarcopenic obesity

  Association between dietary intake of total, plant-based and animal-based protein and the prevalence of sarcopenic obesity.

  through study completion, an average of 1 year

Secondary Outcomes (1)

• Association between dietary protein and lung functions outcomes

  through study completion, an average of 1 year

Interventions

the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes OTHER

Primary Objective The primary objective is to measure the relationship between the quantity and source of dietary protein intake, and the prevalence of sarcopenic obesity, and lung function outcomes, in older female participants with clinically diagnosed COPD. Secondary Objectives The secondary objective is to investigate whether the level of inflammation (plasma CRP) is associated with the intake of total, plant-based and animal-based protein, with the prevalence of sarcopenic obesity, and with lung function outcomes.

Also known as: the level of inflammation (plasma CRP)

Eligibility Criteria

• Age: 55 Years+
• Gender Eligibility Details: Female with COPD aged 55 and over
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women with clinically diagnosed COPD, from GP practices in Aberdeen,United Kingdom, through the Primary Care Research Network.

You may qualify if:

• Women.
• Clinically diagnosed with COPD.
• Aged 55 years or older.

You may not qualify if:

• Male.
• Women who are 54 years or younger.
• Those who have dementia.
• Unable to read or write in English.
• Unable to attend the Human Intervention Studies Unit.
• Those within one year life expectancy.
• Those who have cancer.

Sponsors & Collaborators

• University of Aberdeen: lead

Study Sites (1)

Baukje de Roos

Aberdeen, Scotland, AB25 2ZD, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

A single blood sample will be taken by venepuncture (usually from the antecubital vein) by a trained phlebotomist, after at least 9 hours of fasting overnight. The blood sample will be collected into a heparin tube and spun (for 15 minutes at 2000 x g) to obtain plasma. Plasma samples will be stored at - 80°C until batch analysis of high-sensitivity C-reactive protein (hs-CRP) levels, using the Konelab Clinical Analyser at the Rowett Institute, the University of Aberdeen, Aberdeen, United Kingdom.

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 5, 2024
• First Posted: December 16, 2024
• Study Start: January 1, 2026
• Primary Completion (Estimated): July 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: May 6, 2026

Record last verified: 2026-02

Locations

GB (1)